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  • 1
    Electronic Resource
    Electronic Resource
    Sensitivity of human malignant intracranial tumors against MCNU in vitro in comparison to ACNU and BCNU (1990)
    Springer
    Journal of neuro-oncology 8 (1990), S. 41-45 
    Details
    ISSN: 1573-7373
    Keywords: MCNU ; ACNU ; BCNU ; brain tumors ; chemosensitivity test ; colony forming assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An in vitro chemosensitivity test was carried out in 50 specimen of human malignant intracranial tumors. Aim of the study was to evaluate the proportion of sensitivity against MCNU (Ranomustine) in comparison to ACNU and BCNU. 47 tests were evaluable. Mean viability of the specimen was 83.3 ± 18.7%, mean plating efficiency was 0.068 ± 0.051%. 9/47 settings revealed sensitivity against MCNU in vitro (ACNU: 10/47; BCNU: 16/46). There was no advantage of MCNU concerning age or sex of the patients. Brain metastases seemed to be slightly more frequent sensitive against MCNU than primary brain tumors. Cross resistance between ACNU, BCNU and MCNU was rather high. The results of this in vitro series do not encourage a clinical trial of MCNU as an alternative to the commonly used nitrosoureas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182085
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mitoxantrone-induced DNA strand breaks in cell-cultures of malignant human astrocytoma and glioblastoma tumors (1997)
    Springer
    Journal of neuro-oncology 32 (1997), S. 203-208 
    Details
    ISSN: 1573-7373
    Keywords: mitoxantrone ; malignant human brain tumors ; DNA strand breaks ; alkaline elution ; flourescence spectrophotometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study mitoxantrone (Mtx) induced DNA strand breaks were measured with the alkaline elution technique in short term cell cultures derived from human gliomas. Glioblastomas or astrocytomasfrom 5 patients who underwent intracranial surgery were cultured and incubated 1 h with different concentrations of Mtx (0, 0.01, 0.1 and 1.0 μg/ml). The alkaline elution methodwas modified to measure DNA lesions in human gliomas. Mtx inducedDNA strand breaks in a dose dependent manner in all cell culturestested. There was a linear increase of DNA strand break frequencyinduced by Mtx between 0.01—1.0 μg/ml. Concerning these in vitro data, Mtx might be potentially useful for the treatment ofpatients with malignant brain tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005792410604
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Reservoir systems for intraventricular chemotherapy (1998)
    Springer
    Journal of neuro-oncology 38 (1998), S. 141-143 
    Details
    ISSN: 1573-7373
    Keywords: neoplastic meningiosis ; intraventricular chemotherapy ; ventriculostomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper describes the current techniques for intraventricular drug administration in patients with meningiosis. Advantages and disadvantages of different reservoir systems, the standard implantation procedure and more recently developed image-guided techniques are discussed. In patients with slit ventricles, the CT-based stereotactic approach is recommended for reservoir implantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005991027029
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    Paper (German National Licenses)
    Fulltext
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