ISSN:
1600-0765
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Fifty-six, female, BNL strain mice, 26 weeks of age, received a modified “gingiveclomy” excising, the gingival papilla mesial to the maxillary left first molar. The right maxillae served as the uninjured control site. Additional non-injured mice were utilized as further controls. At varying time intervals, groups containing 4 mice each were sacrificed over a 3 months experimental period. One hour prior to sacrifice, each animal received a subcutaneous injection of 1 uCi of H3TDR/gm of body weight. At sacrifice, both left and right maxillae were dissectedd out and prepared for histologic and autoradiographic study. Following injury, the highest proliferative activity was encountered at the epithelial wound edge. This activity became prominent about 8 to 15 days after injury, while the adjacent crestal epithelium demonstrated a markedly increased activity as early as 16 hours after wounding. The reformed junctional and crevicular epithelium, and adjacent fibroblasts, still exhibited elevated activity at one month post-injury and returned to control range values between one and three month following wounding. The remaining fibroblasts, osteoblasts and cementoblasts around the wound periphery showed markedly elevated activity as early as one to two days post-injury which returned to control levels between 2 to 4 weeks after wounding.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1600-0765.1972.tb01722.x
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