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  • 1
    Electronic Resource
    Electronic Resource
    Rethinking the role of tumour necrosis factor-α in ultraviolet (UV) B-induced immunosuppression: altered immune response in UV-irradiated TNFR1R2 gene-targeted mutant mice (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Ultraviolet (UV) B-induced immunosuppression, implicated in the pathogenesis of skin cancers, is postulated to be mediated in part by cis-urocanic acid (cis-UCA) via tumour necrosis factor (TNF)-α. TNF-α produces morphological changes in Langerhans cells indistinguishable from those induced by UVB exposure and antibodies against TNF-α have been demonstrated to inhibit UVB-induced immunosuppression in vivo. Objectives To clarify further the role of TNF-α in UVB-induced immunosuppression and in cis-UCA immunosuppression. Methods We performed a contact hypersensitivity (CHS) assay on gene-targeted mutant mice (TNFR1R2–/–) lacking genes for both receptors (p55 and p75) for TNF-α. Mice were either irradiated with UVB or injected intradermally with cis-UCA, sensitized with 2,4-dinitrofluorobenzene, challenged on the ears and the response was measured. Results The TNFR1R2–/– mice showed hyporesponsiveness in the CHS response compared with wild-type (P 〈 0·001), confirming the proinflammatory role of TNF-α. However, significant suppression of CHS was seen after irradiation and after cis-UCA injection in both locally (sensitization on irradiated site; P 〈 0·05) and systemically (sensitization on non-irradiated site; P 〈 0·05) sensitized wild-type and gene-targeted mice. Conclusions These results demonstrate that TNF-α signalling is only partially involved in UVB-induced immunosuppression and does not play a major part in the cis-UCA immunosuppression mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04181.x
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  • 2
    Electronic Resource
    Electronic Resource
    Alcoholism as a trigger of multiple symmetric lipomatosis? (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 17 (2003), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2003.00792_15.x
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  • 3
    Electronic Resource
    Electronic Resource
    Von Ebner's Gland (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 694 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb18378.x
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  • 4
    Electronic Resource
    Electronic Resource
    Cytokeratins in hamster cheek pouch epithelium during DMBA-induced carcinogenesis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 18 (1989), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pattern of keratin expression in hamster cheek pouch epithelium during 15-wk of DMBA-induced carcinogenesis was studied. The sequential changes in Cytokeratins of premalignant and malignant tissues and comparative investigation of normal epithelial tissues were examined during a weekly sequential DMBA-induced chemical carcinogenesis. Keratin polypeptides of normal pouch epithelium appear in a molecular weight range of 43–67 kd and 5–6 proteins can be identified. The disappearance of high molecular weight keratin (61–67 kd) was observed from the 6-wk DMBA-treated premalignant group to the 15-wk DMBA-treated malignant group. An additional keratin polypeptide was noted initially on the 11th-wk-DMBA-treated group and remained to the 15th-wk-DMBA treated group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1989.tb00399.x
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  • 5
    Electronic Resource
    Electronic Resource
    Product identification of ameloblastomas: an immunohistochemical study (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 15 (1986), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-nine solid, plexiform and follicular ameloblastomas and control human developing teeth al different stages of maturation were formalin-fixed, paraffin-embedded and sectioned for the study of laminin, fibronectin, and mannosyl, glucosyl, and galactosyl residues using the peroxidase antiperoxidase (PAP) and avidin-biotin peroxidase complex (ABC) staining methods, respectively. Monospecific antibodies to laminin and fibronectin and the affinity of the lectins for mannosyl, glucosyl, and galactosyl residues with RCA-I. Laminin is present during the stage of morphodifferentiation of normal tooth development within the basement membrane. Following cytodifferentiation and calcified matrix deposition, laminin is not detectable. Laminin is also found in the basement membrane of both follicular and plexiform ameloblastomas. In contrast, fibronectin is reactive only up to the stage of morphodifferentiation among the mesenchymal cells and at the epithelial-mesenchymal interface, and it becomes unreactive upon differentiation of odontoblasts and mesenchymal pulp tissue as well. Unlike laminin, fibronectin is unreactive in the basement membrane of plexiform follicular and ameloblastomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1986.tb00654.x
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  • 6
    Electronic Resource
    Electronic Resource
    Expression of endothelial cell markers PAL-E and EN-4 and la-antigens in Kaposi's sarcoma (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eleven biopsy specimens of Kaposi's sarcoma (KS) removed from the skin and oral mucosa were examined immunohistochemically with monoclonal antibodies PAL-E and EN-4, specific for human vascular endothelial cells, and with LN-3 monoclonal antibody reactive with immune-associated (la) antigens in the HLA-DR locus. The early lesions of KS, corresponding to the patch phase, contained hyperplastic venules and an increased number of lymphatic capillaries. The lymphatic capillary endothelium was reactive with EN-4, whereas, PAL-E reacted only with blood vessel endothelial cells. The spindle cells, like lymphatic endothelial cells, were non-reactive with PAL-E but showed positive reaction with EN-4 antibodies. The observed morphologic pattern of vasculogenesis and the demonstrated immune-reactivity in KS support an origin from the venul-lymphatic junction. This is an aberrant pattern but reminiscent of normal embryonal lymphatic channel development. The lymphatic capillaries and vascular slits were nonreactive with LN-3 antibody, but it was positive on cell membranes in a number of spindle cells, suggesting the focal expression of la-anitgens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1988.tb01307.x
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  • 7
    Electronic Resource
    Electronic Resource
    Product definition of pleomorphic adenoma of minor salivary glands (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 14 (1985), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirteen cases of pleomorphic adenoma were studied by both immunohistochemical and other histochemical methods. The exocrine cells and myoepithelial cells appear to produce similar cell products as their normal salivary gland counterparts. Keratin was found in both exocrine cells and myoepithelial cells. CEA, secretory component, and lactoferrin were detected only in the tumor exocrine cells with adenoid differentiation S-100 protein, ferritin. fibronectin. laminin and elastin were detected only in the myoepithelial cells. The residual sugars glucosyl, mannosyl, Galactosyl and fucosyl were identified in both cell, types, in variably detectable amounts
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1985.tb00472.x
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  • 8
    Electronic Resource
    Electronic Resource
    Non-lethal Wiskott–Aldrich syndrome: atopic dermatitis-like lesions persist after splenectomy (2000)
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 39 (2000), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.2000.00869-2.x
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  • 9
    Electronic Resource
    Electronic Resource
    Lupus vulgaris developing at the site of misdiagnosed scrofuloderma (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 17 (2003), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis primarily occurring in developing countries. The recent increase in the incidence of tuberculosis, especially due to human immunodeficiency virus (HIV) infections, has led to a resurgence of extrapulmonary forms of this disease. We describe a case of lupus vulgaris in a 33-year-old woman who had a 5-year history of a slowly growing plaque on her neck. The lesion was located at the site of surgery repairing the scar resulting from the incision of a subcutaneous abscess during childhood. This lesion was misdiagnosed as bacterial abscess. Histopathologic examination of the plaque revealed non-caseating tuberculoid granulomas consisting of lymphocytes, epithelioid and giant cells. Staining for acid-fast bacilli and culture from biopsied tissue was negative. Polymerase chain reaction (PCR) for detection of Mycobacterium tuberculosis DNA, performed on a skin biopsy specimen, was positive. A diagnosis of lupus vulgaris developing at the site of a previous misdiagnosed scrofuloderma was made. Conventional antitubercular therapy with rifampicin, isoniazid and ethambutol was administered for 6 months, resulting in resolution of the lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2003.00783.x
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