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  • 1
    Electronic Resource
    Electronic Resource
    Macrophage antigens associated with adhesion: Identification by a monoclonal antibody specific for lewis lung carcinoma cells
    Amsterdam : Elsevier
    Experimental Cell Research 183 (1989), S. 168-178 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(89)90427-8
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of a static uniform magnetic field on mice (1982)
    Springer
    Radiation and environmental biophysics 20 (1982), S. 153-157 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01323936
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  • 3
    Electronic Resource
    Electronic Resource
    Antitumor properties of chemically detoxified killed Brucella abortus organisms (1981)
    Springer
    Cancer immunology immunotherapy 11 (1981), S. 63-68 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Killed Brucella abortus organisms of the vaccinal strain B19 were detoxified by incubation in NaOH. A 24-h incubation in 0.01 M NaOH increased the LD50 of smooth (S) and rough (R) organisms 2–3 times in normal mice and 50–100 times in adrenalectomized mice. This NaOH treatment did not alter the antitumor activity of Brucella abortus as shown in EL4 lymphoma- and Lewis carcinoma-grafted mice. After incubation in NaOH, S bacteria injected IV retained their ability to provoke spleen hypertrophy and antibody synthesis, and S and R organisms injected into he footpad had comparable ability to induce granulomas. NaOH treatment tended to diminish the mitogenic activity of R bacteria for spleen cell cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205776
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution of radiolabelled monoclonal antibody Po66 after intravenous injection into nude mice bearing human lung cancer grafts (1989)
    Springer
    Cancer immunology immunotherapy 30 (1989), S. 295-299 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monoclonal antibody Po66, produced by immunization against a patient's lung squamous cell carcinoma was found suitable for the scintigraphic detection of human tumours. Surprisingly, the cellular antigen recognized by Po66 was abundant in the cytoplasm of tumour cells but could not be detected on the surface membrane. In the present work the biodistribution of radiolabelled Po66 and of an unrelated immunoglobulin were studied comparatively after intravenous injection into nude mice bearing lung squamous cell carcinoma grafts. Radioactivity distribution among mouse organs and tumour was analysed by gamma counting and autohistoradiography. After injection, radiolabelled Po66 decreased rapidly from the blood in tumour-bearing animals whereas, in controls, it remained at a level comparable to that of the unrelated immunoglobulin. The antibody seemed slowly trapped by the tumour and, 12 days after its injection, distribution ratios between tumour and mouse organs reached values of 20–30 as against 1 in animals injected with the non-specific immunoglobulin. Autohistoradiographic investigations in the tumour confirmed the slow diffusion rate of the antibody, which remained in the vascular spaces up to the 24th hour after injection and diffused afterwards throughout the clusters of tumor cells. Furthermore, radioactivity was detected in cells which, unexpectedly, seemed morphologically unaltered. These cells, the viability of which remains to be determined, were predominant in the central area of the tumours. The results presented constitute new evidence of the ability of an in vivo injected monoclonal antibody to reach a cytoplasmic target inside non-necrotic cells and suggest that the cells permeable to the antibody might be in defective nutritional conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744897
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  • 5
    Electronic Resource
    Electronic Resource
    Resistance to a peritoneal lymphoma graft induced by heat-killed S or R Brucella abortus (1978)
    Springer
    Cancer immunology immunotherapy 4 (1978), S. 49-52 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mice were injected either with the rough (R) or smooth (S) strains of killed Brucella abortus, after which, at various times, they were given an i.p. injection of a strain-specific lymphoma (EL4). In parallel, samples of peritoneal exudate cells were taken from the Brucella-injected mice, and their in vitro cytostatic activity against EL4 tumour cells was investigated. Protection against the lymphoma graft lasted up to the 7th day with S and the 20th with R. In contrast, cytostatic activity was more intense and lasted longer with S than with R. The parallelism between in vivo resistance to the lymphoma graft and augmentation of macrophage cytostatic activity was satisfactory with R but not with S. The differential effects of S and R on EL4 lymphoma growth could not be simply explained on the basis of a difference in macrophage activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205570
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  • 6
    Electronic Resource
    Electronic Resource
    Generation of new macrophages after injection of killed Brucella abortus organisms (1978)
    Springer
    Cancer immunology immunotherapy 4 (1978), S. 247-250 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kinetics of macrophage formation after intravenous injection of inactivated Brucella organisms was investigated in mice. Newly formed macrophages sampled from the peritoneal cavity were identified by their adherence to glass and their recent uptake of tritiated thymidine ( 3 H-thymidine). Radiolabelled cells increased in number from the fifth day after bacterial injection. On the seventh day they were about 20 times as numerous as in the controls. The injection of Brucella also increased the number of Kupffer cells in the liver. The variations in radioactivity in this organ were parallel to those in peritoneal adherent cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200155
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  • 7
    Electronic Resource
    Electronic Resource
    Treatment of human lung carcinoma xenografts with a combination of 131I-labelled monoclonal antibody Po66 and doxorubicin (1997)
    Springer
    Cancer immunology immunotherapy 43 (1997), S. 269-274 
    Details
    ISSN: 1432-0851
    Keywords: Key words Monoclonal antibodies ; Lung cancer ; Animal model ; Radioimmunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Po66, a mouse monoclonal antibody, is directed against an intracytoplasmic antigen present in human lung squamous cell carcinoma cells. In previous work it was found that the co-administration of 125I-radiolabelled Po66 and doxorubicin strongly enhanced the uptake of radioactivity by the tumour. The present-work was designed to evaluate, in a tumour-bearing mouse model of lung carcinoma, the ability of 131I-labelled Po66 to retard tumour growth when injected alone, or in combination with doxorubicin (8 mg kg – 1 at 1-week intervals). A single dose of 550 μCi 131I-Po66 alone had no effect on tumour growth, whereas three fractionated doses of 250 μCi 131I-Po66 decreased it over two doubling times from 14.5±1.5 days for untreated control mice to 24.8±2.7 days. Mice treated with doxorubicin alone had a double tumour doubling time of 22.6±4.9 days, compared to 35.2±2.9 days (1.55-fold increase) in mice treated with doxorubicin and a single dose of 550 μ Ci 131I-Po66. Doxorubicin combined with three fractionated doses of 250 μCi 131I-Po66 provoked a twofold decrease in tumour growth compared to mice treated with doxorubicin alone. The administration of fractionated doses of 131I-Po66 simultaneously with doxorubicin resulted in a highly delayed mortality, which was not observed when 131I-Po66 was administered after doxorubicin. Thus, in a non-small-cell lung tumour model, a 131I-radiolabelled monoclonal antibody, directed against an intracellular antigen, significantly potentiated the effect of chemotherapy. Such a therapeutic approach could be used as an adjuvant therapy and improve the effect of chemotherapy on distant small metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050333
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  • 8
    Electronic Resource
    Electronic Resource
    Modifications du nombre d'unités formatrices de colonies spléniques par des bactéries induisant i'immunostimulation non spécifique (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1223-1224 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Das Verhalten hämopoietischer Stammzellen in Knochenmatk, Milz und peripherem Blut der Maus nach Injektion vonBrucella abortus, Corynebacterium granulosum oderBacillus-Calmette-Guérin wird beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946184
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  • 9
    Electronic Resource
    Electronic Resource
    Sur l'ultrastructure de la glande thyroide humaine (1969)
    Springer
    Cell & tissue research 94 (1969), S. 118-128 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Resumé Des fragments de 6 thyroïdes humaines ont été étudiés au microscope électronique. L'ultrastructure de la glande est rappelée en insistant davantage sur quelques caractères particuliers: Présence au niveau des cellules folliculaires de cils, de glycogène, de dilatations localisées des espaces inter-cellulaires. Les organites participant au processus de secrétion sont étudiés et comparés dans des cellules appartenant à des types vésiculaires différents. Il apparait que le schéma secrétoire est le meme dans toutes les variétés de cellules, les plus hautes ayant l'activité la plus intense. De plus de petites cellules morphologiquement différentes des cellules folliculaires mais situées à leur contact sont décrites, leur nature lymphocytaire est discutée.
    Notes: Summary Specimens of 6 human thyroids have been studied by electron microscopy. In the follicular cells special emphasis has been put on the following features: occurrence of cilia, glycogen, localized widenings of the intercellular spaces. The organelles involved in the secretory process are studied and compared in different cells possessing different types of vesicles. It is concluded that the pattern of secretion may be the same in every cell; the intensity of activity, however, varies a great deal in different cells. In addition, small cells, morphologically different from the follicular cells, but in close contact with them, are described; their lymphocytic nature is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335193
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