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  • 1
    Electronic Resource
    Electronic Resource
    Leukotrienes and isocyanate-induced asthma: a pilot study (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The role of leukotrienes (LTs) in the pathophysiology of isocyanate-induced asthma is not well known.Objective We sought to characterize the type of airway inflammation induced by exposure to isocyanates and to investigate whether exposure to isocyanates induced an increase in LT receptor cysteinyl leukotriene ((CysLT)1, CysLT2 and leukotriene B4 receptor (BLT1)) expression, as well as a release of LT (LTC4 and leukotriene B4 (LTB4)) and IL-8 in both asthmatics with isocyanate-induced asthma and healthy subjects.Methods We investigated eight subjects with isocyanate-induced asthma and eight healthy subjects. Both groups underwent specific inhalation challenges to isocyanates in the laboratory. Induced sputum was collected before and after exposure to isocyanates. CysLT1, CysLT2 and BLT1 expression was assessed by flow cytometry, whereas LTC4, LTB4 and IL-8 were measured in the sputum supernatants by enzyme immunoassay.Results Exposure to isocyanates induced an increase in sputum neutrophils only in subjects with occupational asthma. There was a significant increase in CysLT1 and BLT1 receptor expression, as well as a release of LTB4 and IL-8 after exposure to isocyanates compared with the baseline, only in subjects with isocyanate-induced asthma, whereas there was no increase in LTC4. Exposure to isocyanates did not induce any change in LT receptor expression nor in the levels of LTC4, LTB4 and IL-8, in healthy subjects.Conclusion The neutrophilia observed after exposure to isocyanates is likely to be related to the release of LTB4, probably enhanced by the increased expression of BLT1 on neutrophils as well as by the release of IL-8. The significance of the increase of CysLT1 receptor expression on neutrophils is unknown and needs further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.02102.x
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  • 2
    Electronic Resource
    Electronic Resource
    Rectal tissue, plasma and urine concentrations of mesalazine after single and multiple administrations of 500 mg suppositories to healthy volunteers and ulcerative proctitis patients (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 17 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective : Patients with ulcerative proctitis may have rectal mucosal properties different from healthy volunteers. This project compared the pharmacokinetics of rectally administered mesalazine in these two populations.Methods : In two separate studies, nine patients with ulcerative proctitis and 16 healthy volunteers received a single 500 mg mesalazine suppository and then 500 mg every 8 h for 5 days. Blood samples were collected for 12 h in healthy volunteers and 30 h in patients, and urine for 24 h in healthy volunteers and 30 h in patients. Rectal biopsies were performed 8 h after the last dose.Results : After a single dose to patients, mean mesalazine half-life (s.d.) was 5.0 (3.6) h. At steady-state, means (s.d.) were 89.1 (78.9) ng/mL for Cmin, 361.1 (240.8) ng/mL for Cmax, and 7.1 (7.3) h for half-life. Mean (range) rectal mesalazine concentrations were 167 (1.4–541.6) ng/mg tissue. After a single dose in healthy volunteers, mean (s.d.) half-life was 4.0 (4.7) h. At steady-state, means (s.d.) were 22.4 (61.6) ng/mL for Cmin, 359.4 (166.3) ng/mL for Cmax, and 0.9 (0.5) h for half-life.Conclusion : Mesalazine is released in the rectum of patients, with a bioavailability of about 40%. Tissue distribution is also appreciable. Both parameters appear higher than in healthy volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01409.x
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  • 3
    Electronic Resource
    Electronic Resource
    Population dynamics of gene transfer
    Amsterdam : Elsevier
    Theoretical Population Biology 28 (1985), S. 359-381 
    Details
    ISSN: 0040-5809
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0040-5809(85)90035-8
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  • 4
    Electronic Resource
    Electronic Resource
    Vacuum deposition onto softenable substrates: Formation of novel subsurface structures
    Amsterdam : Elsevier
    Thin Solid Films 101 (1983), S. 21-40 
    Details
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6090(83)90490-X
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  • 5
    Electronic Resource
    Electronic Resource
    Addition and multiplication: Problem-solving and interpretation of relevant data (1986)
    Springer
    Educational studies in mathematics 17 (1986), S. 97-123 
    Details
    ISSN: 1573-0816
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This study constitutes a first step towards the elaboration of a method for intervening in the processes of solving concrete mathematical problems, based on the processing of expressions often included in the statement of addition and multiplication problems presented to second-cycle elementary students (ages 9 to 12). Forty-eight students took part in the experiment: the 29 subjects of the experimental group were divided into small groups of about 5 subjects in each and had to perform various learning exercises. The aim of these exercises was essentially to improve skills in analyzing and processing certain expressions frequently included in the statements of addition and multiplication problems. The effect of these learning exercises on problem-solving was evaluated by a problem-solving pre-test and post-test presented to the subjects in both groups. The learning exercises helped significantly to improve the problem-solving performance of subjects in the experimental group. Analysis of the verbal productions of the subjects in this group during the learning exercises revealed certain factors related to the effectiveness of the method of intervention proposed in this research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311516
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  • 6
    Electronic Resource
    Electronic Resource
    Organic versus anthropogenic acidity in tributaries of the kejimkujik watersheds in Western Nova Scotia (1986)
    Springer
    Water, air & soil pollution 31 (1986), S. 165-1793 
    Details
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Dilute waters (Ca = 0.3 to 0.8 mg L−1) respond by depressed pH levels throughout the year to existing atmospheric wet deposition of sulphate (20 kg ha−1yr−1).This occurs in southwest Nova Scotia particularly during the cold, wet season when runoff is high. Colored waters of similar Ca levels receiving runoff from peaty catchments exhibit pH values one unit lower (4.7 to 4.1) than those of catchments of similar Ca levels but free from peat deposits (pH 〉 5.3). In colored streams sulphate and organic anions show opposing cyclic patterns while the negative gran alkalinity is the near mirror image of sulphate. Sulphate anion peaks during the high spring discharge when the organic anion concentration is lowest. Sulphate suddenly drops during the summer months during periods of high evapotranspiration, low water table and runoff, when the concentration of organic anions is highest. Both Al and Fe follow cyclic patterns similar to that of the organic anions while H+ reflects that of the sulphate anion. Hydrogen ion concentration is always higher than that of sulphate in very colored waters, particularly during the summer months when organic anion concentrations are very high. Analysis of data in the tributaries in the Kejimkujik watersheds indicates that while considerable organic acidity is present in colored waters, anthropogenic sulphate further increases the free acidity of these waters, particularly at times of high discharge.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630831
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  • 7
    Electronic Resource
    Electronic Resource
    Miscible blends of amorphous polymers (1984)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 22 (1984), S. 1857-1870 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Thirty-five polymethacrylate/chlorinated polymer blends were investigated by differential scanning calorimetry. Poly(ethyl), poly(n-propyl), poly(n-butyl), and poly(n-amyl methacrylate)s were found to be miscible with poly(vinyl chloride) (PVC), chlorinated PVC, and Saran, but immiscible with a chlorinated polyethylene containing 48% chlorine. Poly(methyl) (PMMA), poly(n-hexyl) (PHMA), and poly(n-lauryl methacrylate)s were found to be immiscible with the same chlorinated polymers, except the PMMA/PVC, PMMA/Saran, and PHMA/Saran blends, which were miscible. A high chlorine content of the chlorinated polymer and an optimum CH2/COO ratio of the polymethacrylate are required to obtain miscibility. However, poly(methyl), poly(ethyl), poly(n-butyl), and poly(n-octadecyl acrylate)s were found to be immiscible with the same chlorinated polymers, except with Saran, indicating a much greater miscibility of the polymethacrylates with the chlorinated polymers as compared with the polyacrylates.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1984.180221102
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