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  • 1
    Electronic Resource
    Electronic Resource
    Photochemical fluorochrome staining for detection of prenecrotic changes in cardiomyocyte myofibrils (1999)
    Springer
    Bulletin of experimental biology and medicine 128 (1999), S. 967-970 
    Details
    ISSN: 1573-8221
    Keywords: necrobiosis ; cardiomyocytes ; myofibrils ; luminescence and polarization microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ischemic and metabolic damages to cardiomyocytes induce immediate ultrastructural changes in their myofibrils. Photochemical fluorochromize staining of prenecrotic cardiomyocytes allows to determine with high sensitivity local redistribution of sarcomere mass. It is shown that different types of destructive processes in cardiomyocyte myofibrils underlie similar polarization microscopic picture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02438099
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intracellular reorganization and ultrastructural stereological analysis of cardiomyocytes of W/SSM rats with genetically determined cardiomyopathy (1999)
    Springer
    Bulletin of experimental biology and medicine 128 (1999), S. 863-866 
    Details
    ISSN: 1573-8221
    Keywords: W/SSM rats ; hypertrophic cardiomyopathy ; cardiomyocytes ; electron microscopy ; morphometry ; stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We studied ultrastructure of cardiomyocytes of W/SSM rats with inherited hypertrophic cardiomyopathy bred from Wistar rats by hypersensitivity to cataractogenic action of high galactose doses. The observed dynamics of quantitative and qualitative changes in the main sarcoplasmic organelles reflects general principles of spatial and temporal reorganization of cardiac muscle cells induced by hypertrophy of different genesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433836
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Structural features of acute focal metabolic injuries to somatic muscle fibers caused by dimethylparaphenylenediamine (1999)
    Springer
    Bulletin of experimental biology and medicine 127 (1999), S. 640-644 
    Details
    ISSN: 1573-8221
    Keywords: metabolic injuries ; somatic muscles ; polarization microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The pathological picture of an acute disorder of cell metabolism caused by dimethylparaphenylenediamine consists of typical focal reactions of striated muscles to injury: myofibril contractures and intracellular myocytolysis. Analysis of the pathological process demonstrates the time course of contracture injuries as a succession of overcontracture (first-third degree contractures) and necrobiotic phases (fourth degree contracture), followed by lump degradation and macrophagal resorption. Two polar types of contractures are clearly differentiated by the size, shape and structural and metabolic characteristics of target fibers: “ribbons“ and ”medallions”. Disappearance of Z strips, disaggregation, disorientation, and fragmentation of myofibrils are typical of intracellular myocytolysis. The observed changes form the morphological basis for acute disease of striated muscles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02433302
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of repeated complete starvation on quantitative parameters of rat cardiomyocytes (1994)
    Springer
    Bulletin of experimental biology and medicine 117 (1994), S. 665-668 
    Details
    ISSN: 1573-8221
    Keywords: starvation period ; rat myocardium ; cardiomyocytes ; cell population
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Sixty-four male Wistar rats were subjected to repeated complete starvation with free access to water. Each starvation period lasted 6 days and was followed by a 7-day recovery period. The concentration of cardiomyocytes (CMC) and their total number in the left ventricle (LV) were measured after alkaline dissociation of the myocardium. The volume density of muscle fibers and their absolute total mass in the LV were determined by stereological analysis. It is shown that after 6 successive starvation periods the proliferative potential of the CMC population is reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02444350
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  • 5
    Electronic Resource
    Electronic Resource
    General pathological processes in somatic muscles in W/SSM rats with genetically determined metabolic myopathy (1998)
    Springer
    Bulletin of experimental biology and medicine 126 (1998), S. 846-851 
    Details
    ISSN: 1573-8221
    Keywords: somatic muscles ; metabolic myopathy ; W/SSM rats ; polarization and electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Hypertrophy, atrophy, and dystrophy, which reflect the balance between alterative and compensatory-adaptive processes at all levels of structural organization, predominate among structural changes in W/SSM rats with metabolic myopathy under conditions of progressive chronic disorders of cellular homeostasis. Primary universal reactions of striated muscles to damage (myofibril contractures and intracellular myocytolysis) are observed at the ultrastructural level. Increased incidence of focal changes and the time course of morphological and stereological parameters in a constantly functioning organ (diaphragm) indicate that working muscle fibers are most susceptible to injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446927
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    Paper (German National Licenses)
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