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  • 1
    Electronic Resource
    Electronic Resource
    Secondary carcinoma of the thyroid gland (1980)
    Springer
    Surgery today 10 (1980), S. 130-136 
    Details
    ISSN: 1436-2813
    Keywords: thyroid carcinoma ; secondary carcinoma ; squamous cell carcinoma of the thyroid ; metastasis to the thyroid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When the cervical tumor mimics thyroid carcinoma, some cases are shown to be the primary carcinoma of other site. Four cases of secondary thyroid carcinoma, of which primary sites are adjacent organ, are studied. The characteristics of histology are squamous cell carcinoma. Squamous cell carcinoma of which primary organ seems to be thyroid often discloses metastatic neoplasm originated from the adjacent organs. Since chronically inflammatory lesion is recognized concurrently, abnormal thyroid is suggested to be congenial soil for malignant growth. Our experience indicates that the secondary carcinoma due to direct extension should be considered on diagnosing squamous cell carcinoma of the thyroid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468677
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  • 2
    Electronic Resource
    Electronic Resource
    Breast cancer concurrent with hyperthyroidism: A case report (1981)
    Springer
    Surgery today 11 (1981), S. 108-110 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; hyperthyroidism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of breast cancer concurrent with hyperthyroidism was reported and the relation between breast cancer and thyroid dysfunction was reviewed. It has been frequently suggested that the incidence of breast cancer is decreased in patients with hyperthyroidism and breast cancer co-incidental with hyperthyroidism is rare.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468879
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  • 3
    Electronic Resource
    Electronic Resource
    Squamous cell carcinoma of the thyroid —A report of three cases (1990)
    Springer
    Surgery today 20 (1990), S. 341-345 
    Details
    ISSN: 1436-2813
    Keywords: thyroid carcinoma ; squamous cell carcinoma ; papillary carcinoma ; squamous metaplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three cases of squamous cell carcinoma of the thyroid are reported herein. In all cases, the carcinoma occurred in old age and was characterized by a rapidly growing tumor, usually associated with dyspnea and dysphagia. The prognosis of all 3 cases was poor, with a mean survival of only 6.3 months. Although squamous metaplasia is an accepted etiology of this disease, clinical investigation of the cases presented here does not favor it in consideration of the clinical features of papillary carcinoma of the thyroid with squamous metaplasia. The histological findings of our cases revealed areas of cystic formation, suggesting that some of these carcinomas may be derived from remnants of embryonic origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02470671
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  • 4
    Electronic Resource
    Electronic Resource
    Non-Hodgkin's lymphoma of the gastric stump developing 9 years after a distal gastrectomy for a peptic ulcer: A case report and review of the literature (1994)
    Springer
    Surgery today 24 (1994), S. 815-818 
    Details
    ISSN: 1436-2813
    Keywords: gastric lymphoma ; complication of gastrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein the case of a 65-year-old man who developed non-Hodgkin's lymphoma of the gastric stump 9 years after undergoing a distal gastrectomy for a gastric ulcer. The patient presented with epigastric discomfort, and an upper gastrointestinal series and gastroscopy revealed a lymphoma lesion located close to the site of his gastroduodenal anastomosis. A total gastrectomy was performed, followed by combination chemotherapy, comprised of vincristine, Endoxan, prednisone and Adriamycin (VEPA). Histologically, the resected specimen was diagnosed as non-Hodgkin's lymphoma. The patient has :remained well without any signs of recurrence for 18 months since his operation. Although there have been a number of reports of adenocarcinoma devoloping in the gastric stump following surgery for peptic ulcers, the development of malignant lymphoma under such conditions is rare. Following the presentation of this case, we review the available literature and discuss the possibility of malignant lymphoma developing in the gastric stump.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01636312
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  • 5
    Electronic Resource
    Electronic Resource
    Venous invasion as a prognostic factor in colorectal cancer (1995)
    Springer
    Surgery today 25 (1995), S. 950-953 
    Details
    ISSN: 1436-2813
    Keywords: colorectal cancer ; venous invasion ; survival ; DNA ploidy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Venous invasion as a prognostic factor was evaluated in 124 patients with colorectal cancer. By classifying the patients as having either negative to mild invasion or moderate to marked invasion, a significant correlation was found between the degree of venous invasion and clinicopathological variables such as lymphatic invasion, lymph node metastasis, liver metastasis, and DNA ploidy. Significantly more favorable survival was seen in those with a lower degree of vascular invasion; however, of the six prognosticators analyzed by Cox's proportional hazard model, the only significant factors were depth of invasion and DNA ploidy. Although venous invasion showed no significance, it is still considered a valuable prognostic indicator that is easy and economical to perform.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312379
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  • 6
    Electronic Resource
    Electronic Resource
    Prognostic factors associated with differentiated thyroid cancer (1995)
    Springer
    Surgery today 25 (1995), S. 778-782 
    Details
    ISSN: 1436-2813
    Keywords: thyroid cancer ; prognostic factor ; survival ; multivariate analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A multivariate analysis was conducted on the survival data of 180 patients who underwent curative resection for differentiated thyroid cancer between 1966 and 1987, and the 10- and 20-year survival rates were found to be 80.6% and 73.1%, respectively. A survival analysis was also performed, testing the following factors: the patient's age at the time of diagnosis, tumor size, extraglandular extension, nodal status, distant metastases, operative procedure, sex, and histology. A univariate analysis found the initial six factors to be significant prognostic variables, but the latter two to be of no significance. On the other hand, the multivariate analysis showed that distant metastases, age, and tumor size were the most significant prognosticators. Thus, the age of the patient should be taken into consideration during the follow-up of treatment for differentiated thyroid cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311452
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  • 7
    Electronic Resource
    Electronic Resource
    The impact of lymph node metastases on the survival of breast cancer patients with ten or more positive lymph nodes (1997)
    Springer
    Surgery today 27 (1997), S. 902-906 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; lymph node metastasis ; survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate the impact of the number of involved lymph nodes on survival, we retrospectively reviewed the data for 37 patients with breast cancer and metastases of ten or more lymph nodes who underwent treatment between 1987 and 1995. Based on the number of positive lymph nodes, the patients were allocated to one of three groups. The 5-year disease-free and overall survival rates for all patients were both 53.0%. The 7 patients with 26 or more positive nodes had significantly poorer survival than either the 19 patients with 10–15 nodes, or the 11 with 16–25 nodes, although there were no differences in survival related to the extent of node involvement as defined using the Japanese staging system. Patients with 50%–75% frequency of metastasis, defined as the positive nodes/total resected nodes, had significantly better survival than those with 〈50% or 〉75% frequency. These results indicate that the number of involved lymph nodes is related to survival and that 25 positive nodes is a cutoff point in breast cancer patients with ten or more positive lymph nodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02388136
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  • 8
    Electronic Resource
    Electronic Resource
    Rhabdomyosarcoma Presenting as an Anterior Cervical Mass in an Adult: Report of a Case (2000)
    Springer
    Surgery today 30 (2000), S. 1107-1109 
    Details
    ISSN: 1436-2813
    Keywords: Key words Rhabdomyosarcoma ; Cervical tumor ; Head and neck tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein the case of a 61-year-old man who was referred to our hospital for treatment of a rapidly growing tumor in the right anterior cervical region. A 13 × 14 × 15 cm mass was palpated on physical examination. Computed tomography (CT) findings indicated a thyroid tumor, but cytology results suggested rhabdomyosarcoma. A tumor, measuring 9.3 × 7.2 × 5.2 cm and weighing 220 g, was resected and histopathological examination confirmed a diagnosis of rhabdomyosarcoma. Cervical rhabdomyosarcoma is rarely found in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950070009
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  • 9
    Electronic Resource
    Electronic Resource
    Immunohistochemical detection of lymph node microinvolvement in node-negative gastric cancer (1999)
    Springer
    Gastric cancer 2 (1999), S. 173-178 
    Details
    ISSN: 1436-3305
    Keywords: Key words: gastric cancer, regional lymph node, microinvolvement, cytokeratin, prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Background. Despite curative resection of the primary tumor with extensive dissection of lymph nodes, some patients with node-negative gastric cancer die of local relapse or metastatic disease. Microinvolvement of regional lymph nodes may play an important role in the prognosis. Methods. To evaluate the incidence and prognostic implications of regional lymph node microinvolvement in node-negative gastric cancer, we retrospectively analyzed tissue samples from 51 patients operated on for primary gastric cancer. They had tumors that invaded beyond the muscularis propria, but without metastasis to the lymph nodes, shown by the conventional H&E staining method. The regional lymph nodes were examined immunohistochemically, using monoclonal antibodies against cytokeratin. Results. Microinvolvement was found in 4.8% of lymph nodes (67/1390) and in 43.2% of the patients (22/51). The clinical outcome of the patients with microinvolvement was not significantly different from those without it. However, no patient died in the no-microinvolvement group, while three patients in the microinvolvement group died of recurrence. Conclusion. The incidence of microinvolvement in conventionally negative lymph nodes cannot be ignored, and detecting microinvolvement may be important for predicting recurrence of gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101200050042
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  • 10
    Electronic Resource
    Electronic Resource
    Flow cytometric DNA analysis of thyroid carcinoma (1990)
    Springer
    Surgery today 20 (1990), S. 510-514 
    Details
    ISSN: 1436-2813
    Keywords: thyroid carcinoma ; DNA ; flow cytometry ; ploidy ; survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abnormal DNA content has been considered as an additional criterion for determining the biological behavior of a tumor. Flowcytometric DNA analysis was done on 121 patients with thyroid carcinoma encountered during the period between 1975 and 1987. Tumor tissues were sampled from paraffin-embedded blocks and the histology of thyroid carcinoma found to consist of 91 papillary, 23 follicular, 2 medullary, 1 squamous cell and 4 anaplastic carcinomas. The incidence of aneuploidy in thyroid carcinoma was 7.4 per cent (9 patients) while that of diploidy was 92.6 per cent (112 patients). The aneuploid specimens consisted of 6 papillary, 1 follicular, 1 medullary and 1 anaplastic carcinomas and, of 4 anaplastic carcinoma patients with subsequent death within 6 months, only 1 was aneuploid. As an indicator of proliferative potential, S-phase fraction (SPF) was also determined by flow cytometry, but this could not be used as an independent prognostic factor. The aneuploid patients showed a significantly decreased survival rate (p〈0.01). Thus, although DNA measurement proved useful for predicting the survival of aneuploid patients, there is some discrepancy between DNA content and the biological behavior of the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471006
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