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  • 1
    Electronic Resource
    Electronic Resource
    Epidemiological study on the bone mineral density of inhabitants in Miyama Village, Wakayama prefecture (Part II) bone mineral density of the spine and proximal femur (1991)
    Springer
    Journal of bone and mineral metabolism 9 (1991), S. 56-60 
    Details
    ISSN: 1435-5604
    Keywords: Bone mineral density ; Dual energy x-ray absorptiometry ; Osteoporosis ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reference values of bone mineral density (BMD) have mainly been based on hospital volunteers in Japan. Consequently, these values may be inappropriate for the use as a standard in the osteoporotic study. In order to establish reference values, BMD was measured of 400 age-stratified inhabitants of Miyama Village, utilizing dual energy x-ray absorptiometry (DEXA). The mean BMD of L2–L4 in males in each age group was 1.19±0.16 g/cm2 (mean±standard deviation) in 40's, 1.15±0.19 g/cm2 in 50's, 1.03±0.18 g/cm2 in 60's and 1.06±0.25 g/cm2 in 70's. The difference of BMD was statistically significant between the 50 and 60 age groups. On the other hand, in females the mean BMD of L2–L4 was 1.18±0.16 g/cm2 in 40's; 0.99±0.18 g/cm2 in 50's, 0.84±0.19 g/cm2 in 60's and 0.78±0.17 g/cm2 in 70's. The BMD was significantly lower in the 50 age group than in the 40 age group and was similarly lower in the 60 age group than in the 50 age group. The mean BMD of femoral neck in males was 0.98±0.14 g/cm2 in 40's, 0.91±0.12 g/cm2 in 50's, 0.83±0.11 g/cm2 in 60's and 0.78±0.11 g/cm2 in 70's. In females, the BMD of femoral neck was 0.88±0.11 g/cm2 in 40's, 0.75±0.11 g/cm2 in 50's, 0.68±0.11 g/cm2 in 60's and 0.63±0.10 g/cm2 in 70's. BMD of the femoral neck in an older age group was lower than that in a younger age group both in males and females.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02375935
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Up-regulation of ICH-1l protein by thromboxane A2 antagonists enhances cisplatin-induced apoptosis in non-small-cell lung-cancer cell lines (1999)
    Springer
    Journal of cancer research and clinical oncology 125 (1999), S. 389-394 
    Details
    ISSN: 1432-1335
    Keywords: Key words Thromboxane A2 ; Cisplatin ; ICH-1l ; Non-small-cell lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the effect of thromboxane A2 (TXA2) blockade on cisplatin-induced apoptosis in non-small-cell lung cancer (NSCLC) cell lines. Cisplatin induced apoptosis in PC/9 and PC-9/CDDP in a dose-dependent manner. Treatment with specific TXA2 antagonist, calcium 5(Z)-1R,2S,3S,4S-7-[3-phenylsul‐ fonylaminobicyclo[2.2.1]hept-2-yl]-5-heptonoate hydrate (S-1452) and 5(Z-6-{(1R,2R,3R,4S)-3-(N-4-bromoben‐ zenesulfonyl aminomethyl) bicyclo[2,2,1]heptane-2-yl}hex-5-enoic acid (ONO-NT-126), enhanced the cisplatin-induced apoptosis in each cell line. Acetyl-l-aspartyl-glutamyl-valyl-aspart-1-aldehyde (Ac-DEVD-CHO) inhibited cisplatin-induced apoptosis and enhancement of the apoptosis by TXA2 blockade, but acetyl-l-tyrosyl-valyl-alanyl-aspart-1-aldehyde (Ac-YVAD-CHO) had no effect on the apoptosis. There was no difference in the interleukin-1β-converting enzyme (ICE) protease protein expression in either cell line. Cysteine protease p32(CPP32) protein expression was lower in PC-9/CDDP but was not changed by S-1452, cisplatin, or cotreatment with cisplatin and S-1452. Ice and Ced-3 homolog (ICH-1l) expression was significantly lower in PC-9/CDDP and was up-regulated by S-1452 or ONO-NT-126. These data suggest that ICH-1l might play a critical role in cisplatin-induced apoptosis and that TXA2 blockade up-regulates ICH-1l protein expression. Overexpression of ICH-1l and treatment with cisplatin might result in an increase in apoptosis in NSCLC cell lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050291
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hypoxemia is a risk factor for bone mass loss (1999)
    Springer
    Journal of bone and mineral metabolism 17 (1999), S. 211-216 
    Details
    ISSN: 1435-5604
    Keywords: Key words: rat ; DXA ; bone mineral content ; hypoxia ; chronic respiratory failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Time-dependent changes of bone mass in ambulant chronic respiratory failure patients 60 or more years of age were compared between those on home oxygen therapy (HOT) and those still free of HOT (non-HOT). HOT (n = 31) showed initial PaO2 of slightly greater than 60 Torr and non-HOT (n = 32) had PaO2 moderately greater than 60 Torr (64.4 Torr vs 75.1 Torr). PaCO2 in HOT was significantly higher than that of non-HOT (44.8 Torr vs 40.0 Torr). There was no difference in pulmonary function test results. The whole bone mineral density (BMD) as adjusted by age and sex was significantly lower in the HOT group than that in the non-HOT. At endpoints of the follow-up period over 2 years or more, daily bone losses in the whole BMD, whole bone mineral content, and lumber BMD were significantly more accelerated in HOT compared with non-HOT. When the Wistar rats were pair-fed and their locomotion was limited, the animal group placed for 4 weeks under hypoxic air showed a reduction in BMD as compared with the control. We suggest that hypoxemia contributes to bone mass loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007740050087
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    Paper (German National Licenses)
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