ISSN:
1435-2451
Keywords:
Key words Wound infection
;
Hepatobiliary resection
;
Povidone-iodine gel
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Introduction: Despite advances in antibiotic prophylaxis, postoperative wound infection remains a major source of morbidity after digestive surgery. Its prevention is a challenging problem, especially in high-risk patients. The authors introduced a new method to prevent surgical wound infections and evaluated its efficacy in a prospective, randomized trial in markedly high-risk patients. Methods: Patients with biliary tract carcinoma who were scheduled to undergo combined liver and extrahepatic bile duct resection with biliary reconstruction were randomly assigned to one of two groups, well matched in terms of clinical characteristics at baseline. In one group the new treatment was employed (sealed group, n=31), and in the other the wound was treated in the usual fashion (open group, n=28). In the sealed group, povidone-iodine gel was administered to the subcutaneous tissue, and the skin and peritoneum were approximated with a continuous suture. Wound infection was registered up to 30 days after surgery. Results: Wound infection occurred in 18 patients: 5 (16%) patients in the sealed group and 13 (46%) in the open group (P〈0.05). All 18 underwent preoperative percutaneous transhepatic biliary drainage and had positive bile culture findings. In 13 of these 18 patients (72%) the micro-organisms isolated from the infected wound were identical to those in the bile. Conclusions: Our results confirm the close association between infected bile and wound infection in hepatobiliary surgery. Our new method, “direct wound sealing,” is simple, easy to perform, virtually cost-free, and has the potential to prevent wound infections even in markedly high-risk patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004230050156
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