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  • 1
    Electronic Resource
    Electronic Resource
    Solution Structures of Active and Inactive Forms of the DP IV (CD26) Inhibitor Pro-boroPro Determined by NMR Spectroscopy (1994)
    s.l. : American Chemical Society
    Biochemistry 33 (1994), S. 12427-12438 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00207a009
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  • 2
    Electronic Resource
    Electronic Resource
    The Neer classification of fractures of the proximal humerus (1988)
    Springer
    Skeletal radiology 17 (1988), S. 420-422 
    Details
    ISSN: 1432-2161
    Keywords: Classification, fractures ; Proximal humerus, fractures ; Shoulder, injuries ; Weighted kappa statistics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The reliability of the Neer classification of proximal fractures of humerus was examined by determining the agreement between pairs of observers using weighted kappa statistics. Anteroposterior and lateral radiographs of 100 surgical neck fractures were grouped independently by four observers. A low degree of agreement was found, especially between the most inexperienced observer and the rest. Considering the therapeutic consequences of a correct classification, these fractures should be assessed by experienced orthopedic surgeons or radiologists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361661
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  • 3
    Electronic Resource
    Electronic Resource
    A new approach to the newborn screening for hyperphenylalaninemias: use of L-phenylalanine dehydrogenase and microtiter plates
    Amsterdam : Elsevier
    Clinica Chimica Acta 192 (1990), S. 165-170 
    Details
    ISSN: 0009-8981
    Keywords: Enzymatic analysis ; Hyperphenylalaninemia ; Newborn screening ; Phenylketonuria
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(90)90218-H
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  • 4
    Electronic Resource
    Electronic Resource
    Untersuchungen über den Bleigehalt in Wirbeln und Rippen (1978)
    Springer
    Archives of toxicology 41 (1978), S. 133-148 
    Details
    ISSN: 1432-0738
    Keywords: Lead in bones ; Determination ; Rib ; Vertebra ; Human ; Blei in Knochen ; Bestimmung ; Rippen ; Wirbel ; Mensch
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch Extraktion mit Dithizon wurde der Bleigehalt menschlicher Knochen bestimmt. Von 21 Autopsien wurde der Bleigehalt der frischen Wirbel und Rippen mit demjenigen historischer Knochen von 17 Skeletten aus dem 6./8. Jahrhundert n. Chr. verglichen. Die Präparierung und die direkte Mineralisation der Knochen werden beschrieben. Der in der Knochenasche bestimmte Bleigehalt ist niedriger als der, welcher bei direkter nasser Mineralisation der Knochen gefunden wird. Während der trockenen Veraschung, bei welcher Temperaturen von 500° C oder höher angewendet werden, kann Blei verlorengehen. Für dieselbe Person ist der Bleigehalt der Rippe immer niedriger als der im Wirbel gefundene Wert. Der Unterschied im Bleigehalt von frischen Knochen und historischen Knochen ist nur gering. In beiden Gruppen nimmt der Bleigehalt in den Knochen mit steigendem Alter zu. Verglichen mit den in den Jahren von 1930–1970 durchgeführten Untersuchungen anderer Autoren zeigen unsere Resultate, daß die gegenwärtige Aufnahme von Blei in zufälligen Stichproben einer regionalen Bevölkerung nicht größer ist als zu früheren Zeiten.
    Notes: Abstract The dithizone extraction method has been applied in the determination of lead content in human bones. The lead in 21 samples of fresh vertebrae and ribs from autopsies is compared with the lead content of historical bones of 17 skeletons from 600–800 A.D. The preparation and the direct mineralization of the bones are presented. The lead content detected in the ash of bones is to low compared with the value found by direct wet mineralization of the bones. During the dry ashing process with temperatures of 500° C or higher lead may be lost. For the same person the lead content of rib is always lower than the value found in vertebra. The difference of the lead content of fresh bones and the historical bones is only small. In both groups the lead content in the bones increased with age. Compared with studies of other authors in the time of 1930–1970 the results would suggest that the present intake of lead in accidental selected bones among a population situated in an appointed area is not greater than in the past.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302525
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  • 5
    Electronic Resource
    Electronic Resource
    Bestimmung von Morphin und Codein im Urin mit Hilfe der Hochdruckflüssigchromatographie (1980)
    Springer
    Archives of toxicology 45 (1980), S. 241-248 
    Details
    ISSN: 1432-0738
    Keywords: High-pressure-liquid-chromatography ; Morphine ; Codeine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine spezifische und empfindliche Methode zur Bestimmung von Morphin und Codein wird beschrieben. Sie beruht auf der Anlagerung der Substanzen an Amberlite XAD-2-Harz bei pH 8,5 und anschließender Elution mit einem Lösungsmittelgemisch. Nach einem Reinigungsschritt erfolgt die Auftrennung des Rückstandes mittels Hochdruckflüssigchromatographie auf einer „reversed phase”-Säule. Als mobile Phase dient 0,1 M NaH2PO4 in 25% CH3CN/H2O. Der Nachweis der eluierten Komponenten erfolgt mittels UV-Absorption bei 230 nm. Die Methode ist empfindlich, spezifisch und präzis.
    Notes: Abstract A sensitive and specific method for the determination of morphine and codeine is described. The drugs are adsorbed from urine on Amberlite XAD-2 resin at pH 8.5 and eluted from it with organic solvent. After a clean up the residue is separated by high-pressure-liquid-chromatography on reversed phase column using 0.1 M NaH2PO4 in 25% CH3CN/H2O as mobile phase. The eluted drugs are detected by uv-absorption at 230 nm. The method is sensitive, specific and precise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02419005
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  • 6
    Electronic Resource
    Electronic Resource
    Häufigkeit von Medikamenten im Straßenverkehr (1984)
    Springer
    International journal of legal medicine 93 (1984), S. 95-110 
    Details
    ISSN: 1437-1596
    Keywords: Drugs in traffic accident victims ; Drinking drivers ; Blood alcohol and drugs ; Medikamente bei verunfallten Verkehrsteilnehmern ; Alkoholisierte Verkehrsteilnehmer ; Blutalkohol und Medikamente
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung In Übereinstimmung mit der internationalen Literatur fanden sich auch in der Schweiz (Region Bern) bei einem hohen Anteil von Verkehrsteilnehmern im Blut und Urin zentralwirksame Medikamentenstoffe und zwar bei verunfallten Verkehrsteilnehmern der Jahre 1980 und 1981 in 34,7% aller Fälle (n=144), bei 250 Verkehrsdelinquenten aus dem Jahre 1979 in 22,4%. Obwohl die Ergebnisse der vorliegenden Untersuchung bezüglich dem Medikamentennachweis nur qualitativen Charakter haben, ergibt sich aufgrund des Vergleichs mit ähnlichen Untersuchungen der Hinweis, daß auch in der Schweiz die Verkehrssicherheit durch Medikamente negativ beeinflußt wird, wobei der neben dem Medikament oft zusätzlich vorhandene Äthylalkohol die Tragweite des Problems der Medikamente im Straßenverkehr noch vergrößert.
    Notes: Summary Toxicological analyses of blood and/or urine specimens collected between 1980 and 1981 revealed that 34.7% of all traffic accident victims (n=144) had measurable concentrations of drugs. Analyses of blood samples taken from traffic offenders (n=250) in 1979, on the other hand, showed 22.4% to have consumed drugs with or without alcohol. This percentage is comparable with values reported in other studies. Our results indicate that the widespread use of drugs represents a hazard for traffic safety in Switzerland. Road safety is additionally jeopardized by the often concomitant consumption of alcohol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200768
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  • 7
    Electronic Resource
    Electronic Resource
    Über die Anwendung der Kohlepaste-Elektrode zur inversvoltammetrischen Bestimmung kleiner Quecksilbermengen (1975)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 277 (1975), S. 349-353 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Quecksilber ; Voltammetrie, inverse ; Kohlepaste-Elektrode
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Untersucht wird die Anwendbarkeit der Kohlepaste-Elektrode zur Bestimmung kleiner Mengen Quecksilber in 0,1 N KSCN + 0,025 N HCl als Leitelektrolyt, der außerdem 25 ng/ml Kupfer enthält. Das Nachweisvermögen der Quecksilberbestimmung liegt bei 2,5 ng/ml (1,25 · 10−8 M), wenn 10 min bei −1,0 V vorelektrolysiert und die Stromspannungskurve zwischen −0,5 und + 0,5 V mit der Spannungssteigerungsgeschwindigkeit von 16,7 mV/sec aufgenommen wird. In 1,25 · 10−8 bis 1,25 · 10−6 M Lösungen ist die Höhe des Quecksilberpeaks der Quecksilberkonzentration linear proportional. Die Kohlepaste-Elektrode kann bei entsprechender Vorbehandlung für mehrere Messungen benutzt werden, ohne die Oberfläche nach jeder Bestimmung zu erneuern.
    Notes: Abstract The applicability of the carbon paste electrode to the determination of trace quantities of mercury has been investigated in a base electrolyte of 0.1 N KSCN + 0.025 N HCl containing 25 ng/ml copper. The detection limit of the mercury determination has a value near 2.5 ng/ml (1.25×10−8 M), if pre-electrolysis is carried out 10 min at −1.0 V and the current voltage curve is registered with a scan rate of 16.7 mV/sec between −0.5 and +0.5 V. The peak height is directly proportional to the concentration in the range from 1.25×10−8 to 1.25×10−6 M. With appropriate preconditioning the carbon paste electrode can be used for several measurements without renewing the surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00423779
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  • 8
    Electronic Resource
    Electronic Resource
    Über die absolute Konfiguration der Visnagane (1969)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 52 (1969), S. 1165-1174 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: (+)-cis-Khellactone methyl ether (4) and (-)-trans-khellactone methyl ether (6) had earlier been assigned the absolute configurations 3′-S; 4′-S and 3′-S; 4′-R, respectively, on the basis of the FREUDENBERG, rule. Both compounds together with their defunctionalised derivatives (-)-7 and (+)-8 (=(+)-lomatin), obtained from a mixture of (+)-visnadin (1) and (+)-samidin (2), were investigated by the HOREAU method. A conformational analytical study showed that the optical yield should rise in the order 4 〈 6 〈 7, 8. This order was found and the α-phenylbutyric acid liberated was always dextrorotatory. The centre 3′ of the khellactones and their derivatives must be R-chiral and not S. Treatment of (-)-6 with pyridinium perbromide gave (-)-trans-3-bromokhellactone methyl ether (11) as orthorhombic crystals. The X-ray crystal structure determination was made using the anomalous scattering of the Mo-K α radiation by Br. The result,  -  centre 3′ R-chiral (fig. g)  -  showed that the HOREAU method was correct.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19690520503
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  • 9
    Electronic Resource
    Electronic Resource
    Photochemisches Verhalten von 1- und 2-alkylierten 1,2-Dihydronaphtalinen16. Mitteilung über Photoreaktionen; 14. Mitteilung, s. [1]; 15. Mitteilung, s. [2]. (1971)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 54 (1971), S. 2313-2354 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Irradiation of 1-alkyl-substituted 1,2-dihydronaphthalenes (10, 11, 12) with a lowpressure mercury lamp yields by ring opening ω-vinyl-o-quinodimethanes, which undergo [1, 7] H-shifts to give 1,2-divinyl-benzenes (8, 18, 23; cf. schemes 2, 3 and 4). In a further photoreaction of the divinylbenzenes, benzobicyclo [3.1.0]hex-2-enes (17, 19, 22) are formed. 2-Alkyl-substituted 1,2-dihydronaphthalenes (13, 14, 15, 16) are transformed by irradiation into ω-vinyl-o-quinodimethanes, which show [1, 7] H-shifts to yield in this case 2-(buta-1′, 3′-dienyl)-toluenes (9, 25, 26, 27; cf. schemes 6 and 7). The irradiation of 1-methyl- (10) and 1-ethyl-1, 2-dihydronaphthalene (11) with a high-pressure mercury lamp produces, besides the products of irradiation using the lowpressure lamp, 2-ethyl-allenylbenzene (24), and (from 11) 4-exo-ethyl-benzobicyclo[3.1.0]hex-2-ene (exo-20) and 2-propyl-allenylbenzene (21), respectively (cf. scheme 5). Obviously, these products arise from a photreaction of the primarily formed ω-vinyl-o-quinodimethanes a.
    Additional Material: 18 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19710540771
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  • 10
    Electronic Resource
    Electronic Resource
    Photoisomerisierung von o-Di-isobutenylbenzol (1970)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 53 (1970), S. 1323-1330 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: o-Di-isobutenyl-benzene (4) on irradiation in hexane with a low-pressure mercury lamp gives 4 photoproducts in an overall yield of 24%. Three of these products were identified as 4, 4, 6, 6-tetramethyl-benzobicyclo [3.1.0] hex-2-ene (5, main product, 14%), 1.1-dimethyl-2-isopropenyl-indane (6, 8%) and 1-isopropenyl-2, 2-dimethyl-indane (10, 2%). 6 is also formed by irradiation of 5 in hexane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19700530609
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