ISSN:
1365-4632
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
A 75-Year-old while woman was referred to Memorial Sloan-Kettering Cancer Center for evaluation of a slowly enlarging, asymptomatic plaque that had been present on the left breast for several years. She had developed hypothyroidism and hypertension. There was no personal or family history of skin cancer or broast disease. Results of mammography, performed 1 month earlier, were normal. Physical examination revealed an elderly, moderately obose white woman. Examination of the breasts did not reveal any masses, and there were no palpable axillary lymph nodes.On the left breast, tbere was a well circumscribed, orangered plaque, 3 cm in diameter, with a peripheral collarette scale. The lesion was located 2 cm from the areola, in the medio-inferior quadrant of the breast (Fig. 1). A punch biopsy of the lesion showed atypical cells in the epidermis characterized by abundant pale cytoplasm (Fig. 2). Result of PAS stain for glycogen was only weakly positive, and results of all stains for mucin were negative. A lichenoid lymphohistiocytic infiltrate was seen in the dermis. A complete excision of the lesion was performed, revealing Bowen's disease. The specimen contained areas of pagetoid cells (Fig. 2) as well as more typical areas of Bowen's disease (Fig. 3).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-4362.1986.tb03426.x
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