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  • 1
    Electronic Resource
    Electronic Resource
    Clinical significance of thallium-201 and gallium-67 scintigraphy in pulmonary tuberculosis (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 252-257 
    Details
    ISSN: 1619-7089
    Keywords: Pulmonary tuberculosis ; Gallium-67 scintigraphy ; Thallium-201 scintigraphy ; Retention index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One hundred and thirty-nine patients with pulmonary tuberculosis were evaluated by means of gallium-67 and thallium-201 scintigraphy. The disease was clinically active in 83 and inactive in 56. The uptake ratio between the lesion and the contralateral normal lung field was calculated. The ratio determined by67Ga scintigraphy was expressed as GR, and that determined by201Tl scintigraphy (early or delayed) as ER or DR. The201Tl retention index (RI) was calculated using the following equation: RI=DR—ER/ER×100. The sensitivity, specificity and accuracy of201Tl scintigraphy with respect to the activity of pulmonary tuberculosis were better than those of67Ga scintigraphy (the figures for201Tl scintigraphy were 88.0%, 82.1% and 85.6%, respectively, and those for67Ga scintigraphy, 83.1%, 60.7% and 74.1%). We found a significant correlation between GR and ER, but there was no significant correlation between RI and ER. When the relationships between ER, C-reactive protein and 1-h erythrocyte sedimentation rate were examined among patients with abnormal uptake, no significant relationships were noted. In the 27 patients who could be followed up, GR and ER decreased with duration of the therapy, indicating a decrease in disease activity which was consistent with clinical findings. The RI was significantly higher in the early stages of therapy than in the later stages (P〈0.01), suggesting a temporary delay in201Tl washout in the early stages. The washout seemed to be promoted by the effects of the therapy. Overall, it is concluded that201Tl scintigraphy is more useful and more suitable than67Ga scintigraphy for the evaluation of disease activity and therapeutic effects in patients with pulmonary tuberculosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728760
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical significance of thallium-201 and gallium-67 scintigraphy in pulmonary tuberculosis (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 252-257 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Pulmonary tuberculosis ; Gallium-67 scintigraphy ; Thallium-201 scintigraphy ; Retention index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. One hundred and thirty-nine patients with pulmonary tuberculosis were evaluated by means of gallium-67 and thallium-201 scintigraphy. The disease was clinically active in 83 and inactive in 56. The uptake ratio between the lesion and the contralateral normal lung field was calculated. The ratio determined by 67Ga scintigraphy was expressed as GR, and that determined by 201Tl scintigraphy (early or delayed) as ER or DR. The 201Tl retention index (RI) was calculated using the following equation: RI=DR−ER/ER×100. The sensitivity, specificity and accuracy of 201Tl scintigraphy with respect to the activity of pulmonary tuberculosis were better than those of 67Ga scintigraphy (the figures for 201Tl scintigraphy were 88.0%, 82.1% and 85.6%, respectively, and those for 67Ga scintigraphy, 83.1%, 60.7% and 74.1%). We found a significant correlation between GR and ER, but there was no significant correlation between RI and ER. When the relationships between ER, C-reactive protein and 1-h erythrocyte sedimentation rate were examined among patients with abnormal uptake, no significant relationships were noted. In the 27 patients who could be followed up, GR and ER decreased with duration of the therapy, indicating a decrease in disease activity which was consistent with clinical findings. The RI was significantly higher in the early stages of therapy than in the later stages (P〈0.01), suggesting a temporary delay in 201Tl washout in the early stages. The washout seemed to be promoted by the effects of the therapy. Overall, it is concluded that 201Tl scintigraphy is more useful and more suitable than 67Ga scintigraphy for the evaluation of disease activity and therapeutic effects in patients with pulmonary tuberculosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728760
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effects of aldose reductase inhibitor and vitamin B12 on myocardial uptake of iodine-123 metaiodobenzylguanidine in patients with non-insulin-dependent diabetes mellitus (1998)
    Springer
    European journal of nuclear medicine 25 (1998), S. 1643-1648 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Iodine-123-metaiodobenzylguanidine ; Myocardial scintigraphy ; Autonomic disorder ; Aldose reductase inhibitor ; Vitamin B12
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. This study was undertaken to examine the effects of aldose reductase inhibitor (ARI) and vitamin B12 (VB12) on myocardial uptake of iodine-123 metaiodobenzylguanidine (MIBG) in patients with diabetic autonomic disorder. Myocardial scintigraphy using 123I-MIBG was performed on 20 healthy volunteers (controls) and 56 patients with non-insulin-dependent diabetes mellitus (NIDDM), in order to obtain the heart/mediastinum ratio in the initial (HMi) and the delayed images (HMd), and the washout rate (%WR). Thirty-four of the 56 NIDDM patients could be diagnosed as having diabetic autonomic disorder by evaluating their scintigraphic findings in comparison with the controls. Seventeen of these 34 patients received 150 mg/day of epalrestat (ARI group) in three divided doses before meals, and the other 17 received 1.5 mg/day of mecobalamin (VB12 group) in three divided doses after meals, for 3–5 months. According to the presence or absence of clinical symptoms of autonomic or peripheral somatic nerve disorder, the patients were subclassified into four groups. group 1=patients, with autonomic symptoms or somatosensory disorder in the ARI group; group 2=patients without autonomic symptoms or somatosensory disorder in the ARI group; group 3=patients with autonomic symptoms or somatosensory disorder in the VB12 group; and group 4=patients without autonomic symptoms or somatosensory disorder in the VB12 group. After completion of the treatment, myocardial scintigraphy was performed again. Comparing the results obtained before and after the treatment, it was seen that ARI improved only the HMi in group 1 (P=0.046), whereas VB12 significantly improved HMi in the group 3 (P=0.018) and HMi, HMd and %WR in group 4 (P=0.043, P=0.018 and P=0.043, respectively). We conclude that VB12 is more efficacious than ARI in the treatment of diabetic cardiovascular autonomic disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050343
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of the accumulation and efflux kinetics of technetium-99m sestamibi and technetium-99m tetrofosmin in an MRP-expressing tumour cell line (2000)
    Springer
    European journal of nuclear medicine 27 (2000), S. 1786-1792 
    Details
    ISSN: 1619-7089
    Keywords: Technetium-99m sestamibi Technetium-99m tetrofosmin Multidrug resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The potential clinical use of technetium-99m labeled sestamibi (Tc-MIBI) and tetrofosmin (Tc-Tfos) to image tumours is currently being evaluated. In this study, the accumulation and efflux of Tc-MIBI and Tc-Tfos in the nasopharyngeal carcinoma cell line CNE-1 were examined in the presence or absence of various inhibitors of P-glycoprotein (PGP) and/or multidrug resistance associated protein (MRP) activity [GG918, PSC833, verapamil (Vrp), cyclosporin A (CsA) and buthionine sulfoximine (BSO)]. Reverse-transcriptase polymerase chain reaction analysis and immunodetection of the CNE-1 cells detected expression of MRP, MRP1 and MRP2 but not PGP. Tc-MIBI and Tc-Tfos accumulation was increased (P〈0.0001) and efflux decreased (P〈0.05) in the presence of BSO, CsA, Vrp and PSC833 but not GG918, which is a specific inhibitor of PGP. The absolute accumulation of Tc-MIBI was approximately twofold higher than that seen with Tc-Tfos, whereas the addition of inhibitors caused a much greater suppression of Tc-Tfos transport (〉2 times greater than for Tc-MIBI). However, no qualitative differences in inhibitors were seen between Tc-MIBI and Tc-Tfos. These results suggest that both Tc-MIBI and Tc-Tfos are substrates for the MRP transporter and that PSC833, Vrp, CsA and BSO but not GG918 can inhibit MRP activity. These results indicate that Tc-MIBI and Tc-Tfos may be suitable imaging agents for detecting MRP-mediated drug resistance in human cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590000375
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  • 5
    Electronic Resource
    Electronic Resource
    Use of iodine-123 metaiodobenzylguanidine scintigraphy to assess cardiac sympathetic denervation and the impact of hypertension in patients with non-insulin-dependent diabetes mellitus (1999)
    Springer
    European journal of nuclear medicine 26 (1999), S. 1310-1316 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Cardiac sympathetic denervation ; Diabetic cardiomyopathy ; Diabetic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The objectives of this clinical study using iodine-123 metaiodobenzylguanidine (MIBG) scintigraphy were (a) to evaluate cardiac sympathetic denervation in non-insulin-dependent diabetes mellitus (NIDDM) patients with and without hypertension and (b) to investigate the relation between cardiac sympathetic denervation and prognosis in NIDDM patients. We compared clinical characteristics and MIBG data [heart to mediastinum (H/M) ratio and % washout rate (WR)] in a control group and NIDDM patients with and without hypertension. MIBG scintigraphy was performed in 11 controls and 82 NIDDM patients without overt cardiovascular disease except for hypertension (systolic blood pressure ≥140 and/or diastolic blood pressure ≥90 mmHg). After MIBG examination, blood pressure was measured regularly in all NIDDM patients. There were significant differences between 65 normotensive and 17 hypertensive NIDDM patients with respect to age (55±11 vs 63±12 years, respectively, P〈0.05), prevalence of diabetic retinopathy (12% vs 35%, respectively, P〈0.05) and systolic blood pressure (120±12 vs 145±16 mmHg, respectively, P〈0.001). The H/M ratio in hypertensive NIDDM patients was significantly lower than in the control group (1.81±0.29 vs 2.27±0.20, respectively, P〈0.01). During the follow-up period (18± 12 months), 17 NIDDM patients newly developed hypertension after MIBG examination. There were no significant differences in their clinical characteristics compared with persistently normotensive or hypertensive NIDDM patients. %WR in patients with new onset hypertension was significantly higher than in the control group (30.88%±16.87% vs 12.89%±11.94%, respectively, P〈0.05). Moreover, in these patients %WR correlated with duration from the date of MIBG scintigraphy to the onset of hypertension (r=-0.512, P〈0.05). Five NIDDM patients died during the follow-up period (four newly hypertensive patients and one normotensive patient). There were significant statistical differences between the control group and non-survivors in terms of age (54±11 vs 73±11 years, respectively, P〈0.01), H/M ratio (2.27± 0.20 vs 1.64±0.36, respectively, P〈0.01) and %WR (12.89%±11.94% vs 42.52%±22.39%, respectively, P〈0.01). In conclusion, cardiac sympathetic denervation using MIBG scintigraphy observed in hypertensive NIDDM patients, and was more profound in non-survivors. MIBG scintigraphy proved useful for the evaluation of NIDDM patients with new onset hypertension, and it was found that NIDDM patients with abnormalities on MIBG scintigraphy needed to be observe carefully.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050588
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    Paper (German National Licenses)
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