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Dendritic Cells Present an Intracellular Viral Antigen Derived from Apoptotic Cells and Induce a T-Cell Response (2002)

VAN ZANTEN, J. ; HOSPERS, G. A. P. ; HARMSEN, M. C. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Scandinavian journal of immunology 56 (2002), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: We investigated if dendritic cells (DCs) were able to present intracellularly located antigens derived from apoptotic cells to T cells, thereby inducing a CD4+ and a CD8+ response. A transfected cell line with the cytomegalovirus-derived protein pp65 was triggered to go into apoptosis by ultraviolet B (UVB) irradiation, and after the uptake of apoptotic cells by DC, the activation and proliferation of T cells were determined. We found that DC efficiently phagocytosed apoptotic cells and induced a CD4+ and a CD8+ T-cell response specific for the viral protein pp65. This mechanism can be useful for vaccination studies to induce an antiviral immune response.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01125.x

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On the Uniform Convergence of the Empirical Density of an Ergodic Diffusion (2000)

van Zanten, J. H.

Springer

Statistical inference for stochastic processes 3 (2000), S. 251-262

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ISSN: 1572-9311

Keywords: ergodic diffusions ; local time ; empirical density ; uniform convergence ; density estimation

Source: Springer Online Journal Archives 1860-2000

Topics: Mathematics

Notes: Abstract We investigate the uniform convergence of the density of the empirical measure of an ergodic diffusion. It is known that under certain conditions on the drift and diffusion coefficients of the diffusion, the empirical density f t converges in probability to the invariant density f, uniformly on the entire real line. We show that under the same conditions, uniform convergence of f t to f on compact intervals takes place almost surely. Moreover, we prove that under much milder conditions (the usual linear growth condition on the drift and diffusion coefficients and a finite second moment of the invariant measure suffice), we have the uniform convergence of f t to f on compacta in probability.