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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 157 (1998), S. 759-762 
    ISSN: 1432-1076
    Keywords: Key words Chronic renal failure ; Infancy ; Growth retardation ; Conservative treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty infants with chronic renal failure from the first weeks of life, received strict conservative treatment consisting of a protein-restricted, calorie-enriched diet, supplements of essential amino acids, sodium chloride, sodium bicarbonate, calcium and vitamin D. The last 10 patients also received erythropoietin. Neither nasogastric nor gastrostomy tubes were used in any of these patients. Four patients needed dialysis in the second half of the 1st year of life. We analysed the patients' growth in weight, height and head circumference from birth until the age of 12 months. At the age of 12 months, mean values of height, weight and head circumference SDS were −1.63, −1.53 and −1.01 respectively as compared to healthy children. The body length data also compare favourably with those from a large cohort of chronic renal failure patients collected by the European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood; here the mean height SDS at 12 months of age is −3.3. Conclusion This retrospective analysis shows that the generally observed progressive growth retardation in infants with chronic renal failure can be prevented by early and adequate conservative management.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 38-42 
    ISSN: 1432-1076
    Keywords: Key words: Acute renal failure – Haemolytic uraemic snydrome – Prognostic features
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. From January 1970 to December 1982, 95 infants and children with the haemolytic uraemic syndrome were admitted to our unit. Six patients died (6.3%) in the acute phase, 4 went into end-stage renal failure (4.2%) within months after the acute episode. The remaining 85 patients (89.5%) survived and recovered. They were followed as outpatients at yearly intervals for 5 years. Arterial hypertension was a major problem in 7. Eighty patients were studied 10 years later: 52 of them (65%) had no sequelae, 21 (26%) had mild defects and 7 (9%) severe sequelae. Clinical and laboratory data at the onset were analysed for prognostic significance. The immediate outcome was significantly worse in patients with either arterial hypertension or central nervous system manifestations on admission. Yet, no single variable studied during the acute phase was predictive of the presence of sequelae after 10 years. Even when all complications i.e. anuria, hypertension and central nervous system involvement, were taken together, there was no difference between patients with and patients without sequelae.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 129-132 
    ISSN: 1432-1076
    Keywords: Key words: Anaemia – Chronic renal failure – Erythropoietin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Recombinant human erythropoietin was given to eight children and adolescents with stable chronic renal failure in the predialysis state. The hormone was administered subcutaneously, twice weekly for 12 weeks, at a starting dose of 50 U/kg per week. The dosage was adapted every 4th week. Target haemoglobin was 10.5 – 11.5 g/dl, and the target haematocrit 32% – 35%. Baseline haemoglobin levels of 8.20±0.93 g/dl increased to 9.17±1.10, 10.38±1.18 and 11.19±0.84 g/dl (mean±SD) after 4, 8 and 12 weeks respectively. Serum ferritin levels decreased progressively despite iron supplementation. No side-effects were observed: creatinine clearances remained stable, blood pressure did not increase and none of the patients displayed either convulsions or thrombotic features. The study shows that subcutaneous recombinant human erythropoietin is both effective and safe in anaemic children and adolescents with chronic renal insufficiency.
    Type of Medium: Electronic Resource
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