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  • 1
    Electronic Resource
    Electronic Resource
    Validation of a Telephone Zygosity Questionnaire in Twins of Known Zygosity (1998)
    Springer
    Behavior genetics 28 (1998), S. 159-163 
    Details
    ISSN: 1573-3297
    Keywords: Twins ; similarity ; zygosity ; telephone questionnaire
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The aim of this study was to validate a zygosity questionnaire that can be administered over the telephone. Mothers of same-sexed twins of known zygosity and chorionicity between 2 and 31 years of age were interviewed on a nine-item questionnaire. From the answers one unweighted and four weighted indices were computed. As single questions, the mother's opinion and the “two peas in a pod” question differentiated best between monozygotic and dizygotic twins. One independent well-trained observer assessed the zygosity based on the questionnaire and made the correct diagnosis in 96% of the cases. A weighted index of eight similarity questions yielded an accuracy of 98%. This study shows that the zygosity of same-sexed twins more than 2 years old and without gross physical malformation can reliably be determined by a telephone questionnaire with a high accuracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021416112215
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Power of Selective Genotyping in Genetic Association Analyses of Quantitative Traits (2000)
    Springer
    Behavior genetics 30 (2000), S. 141-146 
    Details
    ISSN: 1573-3297
    Keywords: Selective genotyping ; power ; QTL ; association analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion of variance explained by the quantitative trait locus ϖ = 0.01, 0.05, 0.10). We conclude that the method of selective genotyping is a powerful method to detect association for a quantitative trait.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1001907321955
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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