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  • 1
    Electronic Resource
    Electronic Resource
    Cerebral microdialysis as a new tool for neurometabolic monitoring (2000)
    Springer
    Intensive care medicine 26 (2000), S. 662-669 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051230
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship between anterior fontanelle pressure measurements and clinical signs in infantile hydrocephalus (1996)
    Springer
    Child's nervous system 12 (1996), S. 200-209 
    Details
    ISSN: 1433-0350
    Keywords: Hydrocephalus ; Intracranial pressure ; Anterior fontanelle pressure ; Waveform analysis ; Clinical signs ; Infant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The treatment of choice in progressive hydrocephalus is drainage of cerebrospinal fluid in order to reduce elevated intracranial pressure (ICP). Defining the right moment for surgical intervention, however, in a hydrocephalic infant on the basis of clinical signs alone can be a difficult task. Clinical signs of raised ICP are known to be unreliable and sometimes even misleading. In the present study, the relationship between long-term anterior fontanelle pressure (AFP) measurements and clinical signs was investigated in 37 infants with hydrocephalus. The decision as to whether to operate or not was based on clinical signs alone; AFP values were not taken into account. There was an overall difference between the non-operated group and the preoperative measurements in the operated group, and also between the preoperative and the postoperative measurements in the latter, in regard to both AFP measurements and clinical signs. Almost all preoperative AFP values were increased. The direct correlation (ϕ) between most individual clinical signs and AFP levels, however, was low (ϕ=0.15–0.41). The clinical sign “tense fontanelle” showed the best correlation with the AFP levels (ϕ=0.75). Furthermore, using logistic regression analysis, no combination of clinical signs could be found which reliably predicted the AFP. The relationship between the AFP pressure variables and clinical signs was also examined. The pathological A-waves occurred only in the presence of raised (baseline) AFP, a situation in which considerably more frequent B-waves were observed as well. It was concluded that clinical signs of raised ICP in infantile hydrocephalus are not very reliable and AFP monitoring can therefore provide valuable information on intracranial dynamics in patients with dubious neurological manifestations of progressive hydrocephalus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301251
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hemidystonia as presenting symptom of an optic glioma (1997)
    Springer
    Child's nervous system 13 (1997), S. 289-292 
    Details
    ISSN: 1433-0350
    Keywords: Key words Dystonia ; Symptomatic hemidystonia ; Optic glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The first case is presented of an exophytic chiasmatic-hypothalamic glioma causing progressive hemidystonia in an 8-year-old boy, and all 24 reported cases of intra-axial cerebral tumours resulting in symptomatic hemidystonia are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050087
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cisplatin-induced autonomic neuropathy: does it really exist? (1996)
    Springer
    Journal of neuro-oncology 27 (1996), S. 53-60 
    Details
    ISSN: 1573-7373
    Keywords: autonomic ; neuropathy ; cisplatin ; neurotoxicity ; nerve regeneration ; cardiovascular autonomic function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neurotoxic side-effects of cisplatin affect predominantly the large, myelinated fibres of peripheral nerves, leading to a sensory neuropathy. Several reports of cisplatin-associated autonomic neuropathy have been published. Autonomic dysfunction however, is caused by a neuropathy of small unmyelinated nerve fibres. By using the absolute pupil diameter as a parameter of autonomic nervous system function, we studied autonomic neuropathy in the eye of cisplatin-intoxicated rats. In addition, we examined autonomic cardiovascular function by measuring the change in heart rate (HR) and mean arterial blood pressure (MAP) in response to intravenous phenylephrine (PHE) and tyramine (TYR). No significant differences in mean pupil diameter developed in cisplatin-intoxicated rats (n = 12) in the course of 9 weeks (total cumulative dose cisplatin 18 mg/kg) compared with normal controls (n = 9) (MANOVA, F1,19 = 0.88, P 〈 0.36). The PHE- and TYR-induced changes in MAP and HR were virtually the same in cisplatin-intoxicated rats when compared with normal controls. We conclude that cisplatin probably does not cause autonomic dysfunction, at least not in rats, in doses commonly used and which are known to cause a peripheral, sensory neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00146084
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    Paper (German National Licenses)
    Fulltext
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