Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 292 (1981), S. 467-469 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The cytotoxicity of daunomycin is thought to be due to its strong interaction with cellular DNA5'6, thereby interfering with both RNA and DNA synthesis7'8. The experiments described here were designed to determine whether the interaction of daunomycin with DNA is affected by the covalent coupling ...
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Thirteen different strains of micro-organisms able to grow on phenol as a major carbon source were isolated from soil. Among these there were six bacteria, three yeasts, and four mycelial fungi. The oxidation of phenol and catechol by these organisms was studied using the manometric technique and the reaction products were identified by spectrophotometry. In most of the isolated strains, the pathway phenol → catechol →cis, cis-muconate muconate is the main route of phenol degradation. In one of our bacterial strains the extradiol type of catechol cleavage exists together with the intradiol ring fission. In two of the strains investigated, the pattern of oxygen consumption in the presence of phenol and catechol indicated that catechol was not the first intermediate (or not the only one) in the degradation of phenol by these strains. Also the spectra of the oxidation products indicated the presence of a reaction product different from eithercis,cis-muconate or α-hydroxy muconic semi-aldehyde. Washed cells of the majority of the strains accumulated coloured products (possibly quinones) when incubated with phenol or catechol.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1573-4951
    Keywords: Simulated annealing ; Antibody specificity ; Binding-site analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A large comparative study is presented in which the binding of approximately 30 different ligands to two IgE antibodies (La2 and Lb4) is analyzed by means of an automated-docking procedure based on simulated annealing. The method is able to reproduce experimentally verified binding orientations, as shown by application to the Ig-AN02-hapten complex. The main address of the study is to investigate the concept of antibody multispecificity. Problems and usefulness of docking in this context are discussed. The results indicate reasons for multispecific binding properties and how they can be understood from the topology of the binding site. Though similar in general behaviour, the two antibodies show interesting differences in their binding characteristics. The binding sites of both antibodies are described and the main interacting residues revealed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1573-5036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Thirteen different strains of micro-organisms able to grow on phenol as a major carbon source were isolated from soil. Among these there were six bacteria, three yeasts, and four mycelial fungi. The oxidation of phenol and catechol by these organisms was studied using the manometric technique and the reaction products were identified by spectrophotometry. In most of the isolated strains, the pathway phenol → catechol →cis, cis-muconate muconate is the main route of phenol degradation. In one of our bacterial strains the extradiol type of catechol cleavage exists together with the intradiol ring fission. In two of the strains investigated, the pattern of oxygen consumption in the presence of phenol and catechol indicated that catechol was not the first intermediate (or not the only one) in the degradation of phenol by these strains. Also the spectra of the oxidation products indicated the presence of a reaction product different from eithercis,cis-muconate or α-hydroxy muconic semi-aldehyde. Washed cells of the majority of the strains accumulated coloured products (possibly quinones) when incubated with phenol or catechol.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 4 (1976), S. 45-49 
    ISSN: 0091-7419
    Keywords: Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: An improved bubble method was developed for applying an ultrathin layer of nuclear track emulsion on the surface of cells labeled with I125-MSH. The autoradiographs of I125-MSH binding indicate a nonrandom distribution of receptors on the surface of mouse melanoma cells. It is suggested that MSH receptors are displayed in clusters previous to an independently of their exposure to the hormone.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...