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  • 1
    Electronic Resource
    Electronic Resource
    Continuous (R)-mandelic acid production in an enzyme membrane reactor (1989)
    Springer
    Applied microbiology and biotechnology 31 (1989), S. 215-222 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The continuous conversion of phenylglyoxylic acid to (R)-mandelic acid was performed in an enzyme membrane reactor with simultaneous coenzyme regeneration employing mandelate dehydrogenase and formate dehydrogenase. A mathematical model of the coupled enzyme reactions was formulated and applied to determine optimal conditions for (R)-mandelic acid production. The experiments and calculations showed that the optimal operational points depend strongly on enzyme kinetics. The individual kinetic parameters determined were appropriate for the description of (R)-mandelic acid production in the simultaneous two-enzyme process. Space time yields of 700 g/(l·day) were obtained at low enzyme consumption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258398
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acetic acid production by Acetogenium kivui in continuous culture — kinetic studies and computer simulations (1990)
    Springer
    Applied microbiology and biotechnology 34 (1990), S. 344-349 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary This work considers the continuous production of acetic acid by the homoacetogenic and thermophilic bacterium Acetogenium kivui. A mathematical model for the growth kinetics has been developed. The unstructured model for growth and product formation includes product and substrate inhibition as well as maintenance energy effects. The associated model parameters have been identified by non-linear optimization and evidenced experimentally in continuous culture as steady-state data. By using a mineral medium with glucose as the energy and carbon source for the bacteria proper carbon balances are available. The model permits good predictions of steady-state concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170056
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    Paper (German National Licenses)
    Fulltext
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