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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural Studies of a Vesicle System Associated with Endoplasmic Reticulum in Exo-Erythrocytic Forms of Plasmodium berghei (1983)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 30 (1983), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: . Fine structural studies of a specialized vesicle system associated with the endoplasmic reticulum (ER) of exo-erythrocytic Plasmodium berghei suggest that this system may be the equivalent of a Golgi apparatus. Patches of ER, randomly distributed in the cytoplasm of developing parasites, are formed of smooth and ribosome-studded cisternae intermingled with each other. The vesicle systems are located between as well as at the edges of ER aggregates and appear to be in different stages of budding from the cisternae. Prolonged osmication reveals distinct staining of the nuclear envelope and ER of the parasites as well as part of the Golgi apparatus of the hepatocytes. However, the small vesicles associated with the parasite's ER are unstained, as are the coated vesicles in the Golgi region of the liver cell. These sites in the parasite cytoplasm seem comparable to the concave surface of the Golgi apparatus in liver cells. The pinched-off vesicles fuse with others to form the prominent peripheral vacuolization characteristic of the nearly mature exo-erythrocytic form. The formation of these peripheral vacuoles and their subsequent fusion with the parasite membrane may be an exocytosis mechanism supplying the rapidly expanding parasite with new plasma membrane material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1983.tb01042.x
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  • 2
    Electronic Resource
    Electronic Resource
    The biology of tissue forms and other asexual stages in mammalian plasmodia (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1317-1329 
    Details
    ISSN: 1420-9071
    Keywords: Malaria ; Plasmodia ; asexual stages ; sporozoite, exoerythrocytic form ; sporozoite-hepatocyte interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951885
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  • 3
    Electronic Resource
    Electronic Resource
    Malaria parasites—discovery of the early liver form (1983)
    [s.l.] : Nature Publishing Group
    Nature 302 (1983), S. 424-426 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sporozoites of P. berghei ANKA were collected from Ano -pheles stephensi as described previously19 and suspended in normal rat serum20'21. Four-week-old female Brown Norway rats were then inoculated with 25 million sporozoites directly into the portal vein. The flow of the portal blood was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/302424a0
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  • 4
    Electronic Resource
    Electronic Resource
    Histochemical observations on the exoerythrocytic malaria parasite Plasmodium berghei in rat liver (1984)
    Springer
    Histochemistry and cell biology 81 (1984), S. 417-425 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Enzyme histochemical methods were performed on sporozoite infected liver tissue of rats in order to gain insight into the nutrition and metabolism of exoerythrocytic forms of Plasmodium berghei. The following enzymes were demonstrated in the hepatocytic stages of the parasites, obtained 41 and 48 h after inoculation of sporozoites: acid phosphatase, cytochrome oxidase, NADH-tetrazolium reductase, succinate dehydrogenase, NAD+ and NADP+ dependent isocitrate dehydrogenase, NADP+-dependent malate dehydrogenase, lactate dehydrogenases, 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenases and α-glycerol-phosphate dehydrogenase. The results suggest that a conventional Embden-Meyerhoff pathway, pentose phosphate pathway and Krebs' citric acid cycle may in part be present in these exoerythrocytic parasites. Alkaline phosphatase, nucleoside polyphosphatase, 5′nucleotidase. glucose-6-phosphatase, α-glucan phosphorylase, NAD+ dependent malate dehydrogenase, amino-peptidase M and non-specific esterases were not detected by our techniques in the parasite. The enzyme distribution of this intrahepatocytic malaria parasite revealed by histochemistry is compared with the enzyme distribution in the other phases of the parasite's life cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00489744
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  • 5
    Electronic Resource
    Electronic Resource
    Transformation of sporozoites of Plasmodium berghei into exoerythrocytic forms in the liver of its mammalian host (1985)
    Springer
    Cell & tissue research 241 (1985), S. 353-360 
    Details
    ISSN: 1432-0878
    Keywords: Malaria ; Plasmodium berghei ; Sporozoite ; Exoerythrocytic form ; Liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Intrahepatocytic transformation in vivo of the rodent malaria sporozoite of Plasmodium berghei, into the young trophic exoerythrocytic tissue stage was studied by immunofluorescence, light- and electron microscopy. The first 20 h of intracellular life were involved entirely in dedifferentiation with limited proliferation of organelles. From about 20 h onwards nuclear division commenced, rough endoplasmic reticulum became markedly expanded, and mitochondria increased in numbers. However, remains of the sporozoite pellicle (i.e., inner membranes and subpellicular microtubules) persisted for at least 28 h, which correlates with the persisting reaction of young exoerythrocytic forms with antisporozoite antibodies. In general, the basic mechanism of transformation resembles that of the ookinete into oocyst and that of the merozoite into erythrocytic trophozoite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217180
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  • 6
    Electronic Resource
    Electronic Resource
    Electron microscopic studies on the interaction of rat Kupffer cells andPlasmodium berghei sporozoites (1985)
    Springer
    Parasitology research 71 (1985), S. 473-483 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The interactions betweenPlasmodium berghei sporozoites and Kupffer cells in rat liver were studied by transmission electron microscopy. Between 10 and 45 min after inoculation, sporozoites were found in the process of entering Kupffer cells and inside phagolysosomes. The sporozoites entered the Kupffer cells by phagocytosis as determined by the presence of pseudopods and local accumulations of aggregated microfilaments and the resulting exclusion of other organelles in the phagocyte cytoplasm beneath the attached parasite. Sporozoites were taken up either with their anterior end first, or backwards. Scanning electron microscopy of in vitro sporozoite Kupffer cell interaction confirmed these observations. It was concluded that sporozoites are taken up in a normal phagocytic way by the Kupffer cells, regardless of their initial place of contact or position. Thirty min after inoculation sporozoites found in phagolysosomes were still morphologically intact but after 45 min we could encounter completely digested sporozoites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00928350
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  • 7
    Electronic Resource
    Electronic Resource
    Specific lymphocyte transformation in murine malaria (1976)
    Springer
    Parasitology research 50 (1976), S. 95-98 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Lymphoblasten-Transformationsteste wurden an Ratten and Mäusen mit latenter Plasmodium berghei-Infektion ausgeführt. Die Milzzellen von diesen immunisierten Tieren reagierten in vitro mit spezifischem Plasmodium-Antigen, jedoch nicht mit einem Kontrollantigen, das in nicht infizierten Erythrocyten produziert wurde. Die Resultate dieses Tests in vitro waren von der Konzentration des Antigens und der Einwirkungszeit abhängig. Es wurde eine Korrelation der Parasitämie zwischen diesen Tieren während der akuten Infektion und der Reaktion in vitro festgestellt: Je höher die Parasitämie, desto höher die Stimulation in vitro.
    Notes: Summary Lymphoblast transformation tests were performed on convalescent rats and mice, after infection with Plasmodium berghei had been reduced to latency. Spleen cells from immune animals reacted in vitro to specific plasmodial antigen and not to control antigen produced from non infected RBC. The response in vitro was dependent on the concentration of the antigen and the time of exposure to it. A correlation was observed between the parasitaemia of the convalescent animal during its acute infection and the reaction in vitro: the higher the parasitaemia the higher the in vitro stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389938
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  • 8
    Electronic Resource
    Electronic Resource
    The demonstration ofPlasmodium berghei sporozoites in rat hepatocytes one hour after inoculation (1982)
    Springer
    Parasitology research 67 (1982), S. 345-348 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00927671
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