ISSN:
1432-1246
Keywords:
Review
;
Biotransformation
;
Metabolism
;
Elimination
;
Toxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A general review of the common pathways for biotransformation (metabolism) of foreign organic compounds, i.e. xenobiotics, is presented. Many factors are mentioned that can influence the result of exposure to chemicals and thus the toxicity: Firstly the uptake is often influenced by some factors, e.g. by the work load. Secondly, the type of and capacity for biotransformation is influenced by e.g. genetic background and can be increased by induction of capacity limiting enzymes and decreased by e.g. inhibition. Interferences with other chemicals, drugs and alcohol can cause significant adverse effects. Potential risks that may be linked with biotransformation are discussed, as for example the formation of reactive products, e.g. epoxides which may initiate cancer and allergy. Thirdly, the rate of elimination is influenced by e.g. depots, degree of protein binding, and liver as well as kidney function. Many arguments are presented for analysis of substances or biotransformation products and the use of biochemical limit values. In short, this implies a health control of each individual and his characteristic response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01848257
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