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  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Sirolimus is a potent immunosuppressive medication that acts by inhibiting T-cell proliferation. It has been used in kidney transplantation because of its lack of nephrotoxicity. It is now being investigated in liver transplantation, but there are concerns about safety and long-term side effects such as dyslipidaemia. Hypertriglyceridaemia is a common adverse event seen with sirolimus use, and often does not respond to dose reduction or anti-lipemic drugs.Method : We report six patients who have developed significant hyperlipidaemia while receiving sirolimus, in spite of therapeutic trough levels.Conclusion : All six patients showed either resolution or improvement in lipid levels with discontinuation of sirolimus.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA - Protein Structure 160 (1968), S. 53-62 
    ISSN: 0005-2795
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of orthopaedic surgery & traumatology 2 (1992), S. 215-216 
    ISSN: 1432-1068
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of orthopaedic surgery & traumatology 2 (1992), S. 207-213 
    ISSN: 1432-1068
    Keywords: Instability ; Ligamentoplastie ; Ankle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A multicentre review of 182 chronic laxities of the ankle treated surgically is reported. Two thirds of the cases are failures of conservative treatment after the initial accident. The instability is expressed in two ways: either by minor recurring accidents in 62% of the cases which are preferably submitted to proprioceptive rehabilitation before surgery, or by serious sprains which come more easily to surgery with a richer objective symptomatology. Radiographical examinations have only a relative value and do not correspond to the seriousness. The anterior drawer radiograph seems more reliable than the forced varus radiograph. The surgeon is confronted with two anatomo-clinical situations: the tibio-tarsal laxity, pure or associated in 22% of the cases with a sub-astragalar laxity. The review of the techniques used shows the interest in combining plasties and sutures. The reinforcement plasties of the retention of the anterior detachment type, of the sling type plasty of the ligament, or by fibular fibroperiosteal strip, seem preferable to autologous tenontoplasties particularly of the peroneus brevis. The assessment of the results according to the type of chronic laxity, of the main techniques used, of the post-operative problems observed, confirm the plasties which appear the most judicious to us.
    Notes: Résumé Une revue multicentrique concernant 182 laxités chroniques de cheville traitées chirurgicalement, est rapportée. Deux tiers des cas sont des échecs du traitement conservateur après l'accident initial. L'instabilité se traduit sous deux aspects: soit par des accidents bénins récidivants dans 62 % des cas qui sont soumis de préférence à une rééducation proprioceptive avant la chirurgie, soit par des accidents graves d'entorse qui viennent plus facilement à la chirurgie avec une symptomatologie plus riche du point de vue objectif. Les explorations radiographiques n'ont qu'une valeur relative et ne sont pas parallèles à la gravité.La radiographie en tiroir antérieur semble plus fiable que la radiographie en varus forcé. Le chirurgien est confronté à deux situations anatomo-cliniques: la laxité tibio-tarsienne pure, ou associée dans 22 % des cas à une laxité sousastragal ienne. La revue des techniques utilisées montre l'intérêt d'associer plasties et sutures. Les plasties de renforcement type rétention du décollement antérieur, type plastie au ligament frondiforme, ou par bandelette fibro-périostée péronière, semblent préférables aux ténoplasties autologues notamment du court péronier latéral. L'évaluation des résultats en fonction du type de laxité chronique, des principales techniques pratiquées, des troubles post-opératoires observés, confirment les plasties qui nous semblent les plus judicieuses.
    Type of Medium: Electronic Resource
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