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  • 1
    Digitale Medien
    Digitale Medien
    Reduction of scar formation in full-thickness wounds with topical celecoxib treatment (2003)
    Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 11 (2003), S. 0 
    Details
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Adult wound repair occurs with an initial inflammatory response, reepithelialization, and the formation of a permanent scar. Although the inflammatory phase is often considered a necessity for successful adult wound healing, fetal healing studies have shown the ability to regenerate skin and to heal wounds in a scarless manner in the absence of inflammation. The cyclooxygenase-2 (COX-2) enzyme, a known mediator of inflammation, has been shown to contribute to a variety of inflammatory conditions and to the development of cancer in many organs. To examine the role of COX-2 in the wound healing process, incisional wounds were treated topically with the anti-inflammatory COX-2 inhibitor celecoxib. Acutely, celecoxib inhibited several parameters of inflammation in the wound site. This decrease in the early inflammatory phase of wound healing had a significant effect on later events in the wound healing process, namely a reduction in scar tissue formation, without disrupting reepithelialization or decreasing tensile strength. Our data suggest that in the absence of infection, adult wound healing is able to commence with decreased inflammation and that anti-inflammatory drugs may be used to improve the outcome of the repair process in the skin by limiting scar formation. (WOUND REP REG 2003;11:25–34)
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1524-475X.2003.11106.x
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of physico-chemical and molecular mobility parameters on Staphylococcus aureus growth (2003)
    Oxford, UK : Blackwell Science Ltd
    International journal of food science & technology 38 (2003), S. 0 
    Details
    ISSN: 1365-2621
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The role played by water activity, ‘mobility’ and physico-chemical properties of the media in modulating microbial response has been the object of large debate in the scientific community. In this study, Staphylococcus aureus growth parameters (lag phase and cell density at 24 h) in brain heart infusion (BHI) and BHI:NaCl (1:1) were analysed in their correlation with physico-chemical/mobility parameters descriptive of the media [solid content, aw, kinematic viscosity, 17O NMR (R2, Pbw and 〈inlineGraphic alt="inline image" href="urn:x-wiley:09505423:IJFS738:IJFS_738_mu1" location="equation/IJFS_738_mu1.gif"/〉)]. In these high moisture content, liquid and ‘homogeneous’ media S.aureus growth related to all the physico-chemical and molecular mobility parameters analysed in a similar manner and it was found to be influenced more significantly by added NaCl than by the physico-chemical and molecular mobility of the media. Staphylococcus aureus growth parameters correlated better with aw (relatively independent of NaCl concentration) than with any other parameter considered in this study.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2621.2003.00738.x
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