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  • 1
    Electronic Resource
    Electronic Resource
    Controlled exposure to mite allergen for a dose-finding of dimethindene maleate (DMM) (1994)
    Springer
    Inflammation research 41 (1994), S. C124 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to develop a laboratory system to challenge mite allergic patients with physiological concentrations of Der p I in order to evaluate the efficacy of antiallergic drugs in mite allergic patients. A double-blind, placebo-controlled, cross-over study was designed with three consecutive sessions. Twelve patients with proven sensitivity to dust mite were treated with a single dose of dimethindene maleate in a FOAD formulation (4 and 8 mg vs. placebo) 12 h before a long-term challenge with mite allergen Der p I in the Vienna challenge chamber. Challenge was performed with a constant concentration of 40 ng Der p I per cubic meter of air for 4 h. Nasal parameters were recorded at 15 min intervals during long-term challenge. In comparison to placebo, dimethindene leads to a statistically significant reduction (p〈0.05) of the nasal response at both concentrations tested. The house-dust mite model in the Vienna challenge chamber thus proved to be a useful tool for drug investigations in mite allergies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02007795
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  • 2
    Electronic Resource
    Electronic Resource
    The treatment of incisional and abdominal hernia with a prosthesis in potentially infected tissues — A series of 47 cases (1997)
    Springer
    Hernia 1 (1997), S. 157-161 
    Details
    ISSN: 1248-9204
    Keywords: Incisional hernia ; Surgical treatment ; Prosthesis ; Infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to assess the infective risks involved in the placement of a non-absorbable prosthesis in the abdominal wall, in the treatment of abdominal hernias. Two groups of patients were compared over the period 1985 to 1995. Group A (N=47) received non-absorbable (Mersilene) prostheses, placed in a potentially infected area (Altemeier class 2, 3 and 4). Group B (N=47, Altemeier class 1) comprised a similar group of patients to those in group A. The prostheses were usually placed in the retro-muscular prefascial plane. Antibiotics were given either prophylactically or therapeutically, according to the degree of sepsis surrounding the operation. The length of hospital stay was longer in group A (15.6 ± 9 as against 10 ± 6 days. p=0,0006). There were two deaths in group A and none in group B (not significant). The general complication rate was 23.7% in group A as against 8.5% in group B (p=0.016). There was no significant difference between the two groups in regard to surgical complications (group A 23.7%, group B 21.3%). The infection rate in the abdominal wall was 10.6% and 6.4% in groups A and B respectively (not significant). There was only one patient with a prosthetic infection (in group A) requiring revision. We conclude that the use of non-absorbable prostheses placed in the retromuscular prefascial space may be more widely employed, in the course of potentially contaminated intra-abdominal surgery of Altemeier class 2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01234750
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of a massive incisional abdominal wall hernia requiring subtotal colectomy using a dual facing mesh (2000)
    Springer
    Hernia 4 (2000), S. S22 
    Details
    ISSN: 1248-9204
    Keywords: Incisional hernia ; Intraperitoneal ; Adhesion prevention ; Obesity ; Mesh
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case report of a giant abdominal wall defect in a 62-year-old woman is reported. Diabetes and severe overweight (BMI: 52) were noted as associated risk factors. Previous surgical treatment had been performed in 1982 using a retromuscular polypropylene mesh. This treatment failed in 1998. Preoperative medical treatment was started 8 months before for skin infection. Progressive pneumoperitoneum was used to create a space to accommodate herniated viscera and facilitate fascial repair with minimal tension. To palliate the parietal defect, we used a new mesh placed intraperitoneally. This mesh was made up of a dual facing mesh combining a three-dimensional polyester covered on one of its sides with an adhesion-preventive, hydrophilic and absorbable film (Parietex® Composite-Sofradim). The borders of the defect were individualized by total excision of the hernial sac. A subtotal colectomy with handsewn ileocolic anastomosis had to be performed to allow for reintroduction of the small bowel into the cavity. The omentum was used as a complementary barrier to cover the abdominal viscera as well as the ileocolic anastomosis. Two 20 × 25 cm meshes were juxtaposed to ensure a very broad parietal application and secured on the posterior abdominal sheath. A dermolipectomy completed the procedure, after closing the anterior wall without tension. No parietal complication was noted and the patient recovered normal activity within 2 months. In view of the good results found in the literature of intraperitoneal mesh placement, this new mesh should be considered as a very useful approach to large incisional abdominal hernia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01387178
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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