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  • 1
    Electronic Resource
    Electronic Resource
    H -2 d Antigens on Mouse Spermatozoa (1969)
    [s.l.] : Nature Publishing Group
    Nature 222 (1969), S. 1293-1294 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The mice we used were two H-2 congenic strains, C57BL/10ScSn (or BIO) with the allele H-2*〉 and B10.D2 carrying the allele H-2〈*. BIO anti-B10.D2 sera were produced by injecting BIO females intraperitoneally with suspensions of normal lymphoid B10.D2 cells in phosphate-buffered saline ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2221293a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ESTABLISHMENT AND CHARACTERIZATION OF PERMANENT MURINE HYBRIDOMAS SECRETING MONOCLONAL ANTI-THY-1 ANTIBODIES (1980)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 7 (1980), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Hybridomas secreting anti-Thy-1 antibodies were produced by fusing cells of the mouse myeloma line P3-NSI/1-Ag4-1 (NS-1) with spleen cells from AKR/J mice immunized with C3H/Di thymus cells and by subsequent growth in tissue culture and selection of the hybrid cells. Two permanent hybridomas, 1B5 and 1aG4/C5, secreting antibodies of IgG3 subclass were isolated by repeated cloning of cells by dilution and in soft agar. Growth of the hybrid cell colonies depended on the presence of feeder cells; spleen cells at 1-2 X 106/ml were most effective, then thymus cells at 1-4 X 106/ml and peritoneal cells at a concentration 1-2 orders of magnitude lower.The two hybridomas were grown in vitro or in vivo and their products were further analysed. In tissue culture in serum-free medium under the optimum conditions the supernatant from hybridoma 1B5 contained 0.07 mg/ml of antibodies and that from hybridoma 1aG4/C5 had 0.26 mg/ml of antibodies, whereas ascites 1B5 contained 3.6 mg/ml and ascites 1aG4/C5 4.4 mg/ml of antibodies.A very low electrophoretic mobility of both antibodies facilitated their isolation. The specificity of the antibodies was tested in the cytotoxicity assay in the presence of complement and by the binding of isotopically labelled antibodies to thymus cells from A/Ph mice and other Thy-1.2+ strains and A. Thy-1.1 and AKR/J mice. Antibodies of clone 1aG4/C5 were specific for Thy-1.2+ cells, whereas antobodies of clone 1B5 at higher concentrations also reacted with Thy-1.1+ cells from the thymus and lymph nodes. Both antibodies killed more than 95% thymus cells and 60-70% lymph node cells in the cytotoxicity assay. The specificity of antibodies for T lymphocytes was confirmed in the functional test in which the antibodies eliminated the response of spleen cells to Concanavalin A but did not affect the response to lipopolysaccharide in the presence of complement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1980.tb00741.x
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  • 3
    Electronic Resource
    Electronic Resource
    Homograft response and lymphocyte level in thymectomized and/or bursectomized ducks (1963)
    Springer
    Cellular and molecular life sciences 19 (1963), S. 484-485 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Der Einfluss der Exstirpation von Bursa fabr. und Thymus junger Enten wurde zur Erklärung der Bedeutung dieser Organe für die Entwicklung der immunologischen Reaktivität untersucht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150662
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  • 4
    Electronic Resource
    Electronic Resource
    Distant Hybrids from Parents with Reduced Immunological Reactivity (1958)
    [s.l.] : Nature Publishing Group
    Nature 181 (1958), S. 927-928 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] I wished to verify whether a distant cross of the above combination was favourably influenced by a decrease in the reciprocal inxnaunological reactivity of both the parent birds. The results support this assumption, as I obtained four hybrids which have survived into maturity. Fig. 1. Course of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/181927a0
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  • 5
    Electronic Resource
    Electronic Resource
    On the possibility that thymus-mediated alloantigenic stimulation results in tolerance response (1965)
    Springer
    Cellular and molecular life sciences 21 (1965), S. 661-663 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé La tolérance de transplantation a été induite dans une combinaison antigéniquement faible du donneur et receveur par l'irradiation subléthale et le prétraitement antigénique spécifique chez la souris adulte. Les résultats obtenus sont compatibles avec l'idée que la fonction hypothétique du thymus lors du développement de l'autotolérance puisse jouer un rôle même dans la tolérance expérimentelle envers l'antigène étranger autant que cet antigène est permis d'entrer, sur quelque principe, dans le thymus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02144067
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of an antiandrogen on the lymphoid system (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 1202-1203 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A side-effect of the administration of cyproterone acetate, an antiandrogenic steroid, to newborn, juvenile or adult male mice (in doses comparable to those used clinically) was found in a marked reduction of the white pulp of the spleen and reduced weight or even absence of the thymus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01927627
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