ISSN:
0942-0940
Keywords:
Vasospasm
;
subarachnoid haemorrhage
;
calcium antagonist
;
nimodipine
;
intrathecal administration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Specific antagonists to the influx of calcium, necessary for the excitation-contraction coupling process in arterial smooth muscle, are potentially useful in the treatment of cerebral vasospasm but systemic hypotension might limit their clinical applicability. We studied the effect of the calcium antagonist nimodipine (BAY e 9736) on cerebral arterial spasm, intraventricular pressure and blood pressure (BP), when administered into the cerebral ventricles of the dog. Cerebral vasospasm was produced by the injection of autologous blood into the cisterna magna. In a group of 8 dogs, 100 μg of nimodipine was injected into the lateral ventricle. The effect of the drug on the basilar artery was monitored angiographically. Nimodipine always relieved spasm, and often the relaxation surpassed the resting vessel diameter. In a control group, the injection of placebo did not relax the spastic arteries. Determinations using gas chromatography of nimodipine in CSF and blood demonstrated that a concentration of 1 μg/ml in cisternal CSF was sufficient to reduce spasm while concomitant plasma concentrations of 0.004 μg/ml did not result in significant BP reduction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01406653
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