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    Design Research Programs and the Logic of Their Development (1992)
    Dordrecht : Periodicals Archive Online (PAO)
    Erkenntnis. 37:1 (1992:July) 37 
    Details
    ISSN: 0165-0106
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:n420-1992-037-01-000003
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  • 2
    Electronic Resource
    Electronic Resource
    Design research programs and the logic of their development (1992)
    Springer
    Erkenntnis 37 (1992), S. 37-63 
    Details
    ISSN: 1572-8420
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy
    Notes: Abstract Design research programs attempt to bring together the properties of available materials and the demands derived from intended applications. The logic of problem states and state transitions in such programs, including assessment criteria and heuristic principles, is described in settheoretic terms, starting with a naive model comprising an intended profile and the operational profile of a prototype. In a first concretization the useful distinction between structural and functional properties is built into the model. In two further concretizations the inclusion of potential applications is motivated and described for the case of drug research as well as the inclusion of potential realizations for the case of complex products. Next, another line of concretization of the naive model, the incorporation of potentially relevant properties, is sketched. Then the partial analogy between “product-” and “truth-approximation” is indicated. We conclude with some remarks about the usefulness of our models for products reaching the market in comparison to the the so-called social construction of technology approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220632
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  • 3
    Electronic Resource
    Electronic Resource
    How adverse drug reactions can play a role in innovative drug research (1995)
    Springer
    Pharmacy world & science 17 (1995), S. 195-200 
    Details
    ISSN: 1573-739X
    Keywords: Angiotensin-converting enzyme inhibitors ; Adverse effects ; Captopril ; Drug design ; History of pharmacy ; Penicillamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract We describe how adverse drug reactions (ADRs) can play an important role in pharmaceutical research and drug development. Not only do ADRs represent the risks and drawbacks associated with drugs but they can also be related to other knowledge available in pharmaceutical and medical research. We offer a model that can be used to systematically map the pathways through which ADRs can lead to innovative research. These pathways include chemical, therapeutic or pathophysiological steps that can be taken to arrive at new knowledge based on ADRs. We used the development of angiotensin-converting enzyme inhibitors, especially captopril, as a case study. The similarity between the ADR profiles of captopril and penicillamine was a starting point for further innovation. Historical analysis shows that in several instances research in the field of angiotensin-converting enzyme inhibitors has been triggered by ADRs. The model presented here might be applicable to other areas of innovative drug research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870611
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  • 4
    Electronic Resource
    Electronic Resource
    Technology in Medicine: Ontology, Epistemology, Ethics and Social Philosophy at the Crossroads (2000)
    Springer
    Theoretical medicine and bioethics 21 (2000), S. 1-7 
    Details
    ISSN: 1573-1200
    Keywords: Philosophy of technology ; technology ; medical practice ; ontology ; disease concept ; normality ; autonomy ; risk and trust ; health technology assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Philosophy
    Notes: Abstract In reference to the different approaches in philosophy(of medicine) of the nature of (medical) technology,this article introduces the topic of this specialissue of Theoretical Medicine and Bioethics, that is,the way the different forms of medical technologyfunction in everyday medical practice. The authorselaborate on the active role technology plays inshaping our views on disease, illness, and the body,whence in shaping our world.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009903321229
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