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  • 1
    Electronic Resource
    Electronic Resource
    Labelling index in the mucosal lesions of lichen planus (1974)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 91 (1974), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The labelling indices of the epithelium of the lesions of oral lichen planus (LP) have been estimated, using in vitro labelling with tritiated thymidine. The relationship between this epithelial labeling index and the underlying inflammatory cell density was also examined. The total labelling activity in the LP lesion was comparable with that of normal mucosa but was redistributed as follows. The labelling index of the basal epithelial layer was increased above that of normal controls and the labeling in the suprabasal layer was decreased. Thus 50% of mitoses occur basally in involved atrophic LP epithelium. The implications of this redistribution of mitotic activity are discussed.The labelling index of epithelium was reduced where the inflammatory cell density was exceptionally high, but no simple inverse relationship between labelling index and inflammatory cell density was apparent. This supports the concept that the primary event in lichen planus seems to occur in the basal epithehal layer followed by an inflammatory cell response in the underlying connective tissue. Subsequent secondary damage to the epithelium, including inhibition of mitosis, may be produced by this inflammatory infiltrate only if it is very dense.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1974.tb12943.x
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  • 2
    Electronic Resource
    Electronic Resource
    The origins of the human immunodeficiency viruses: an update (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 21 (1992), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In 1981 a new acquired immunodeficiency syndrome was first described. The disease has a 100% mortality rate and over 359,000 cases have been reported to the WHO from 162 countries. The WHO estimates that the cumulative global total of AIDS cases as of early 1991 is more than 1.5 million. The dental profession, in line with other health care professions, is involved with guiding rational efforts to stop transmission and with developing effective means of treatment and prevention. This paper reviews the nature of the virus, its possible origins, and the implications of such origins for treatment and prevention of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1992.tb00091.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The inflammatory infiltrate in lichen planus lesions (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 5 (1976), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The labeling index of the infiltrate of oral lichen planus lesions was significantly greater than that of normal mucosa, and its labeling activity redistributed, as determined by in vitro autoradiography. An electron microscopic examination of the infiltrate of lichen planus lesions of oral mucosa and skin supported the concept that the lichen planus infiltrate represents a cell mediated immune response in which T lymphocytes and macrophages are predominant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1976.tb01776.x
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  • 4
    Electronic Resource
    Electronic Resource
    Peripheral blood leucocytes with receptors for extracts of dental plaque (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 16 (1981), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The percentage of peripheral blood leucocytes with receptors for dental plaque has been determined with a rosetting assay. Patients with periodontal disease had a significantly greater mean fraction of leucocytes with receptors for a plaque extract than could be detected in leucocytes from healthy subjects. The percentage of plaque binding leucocytes was dependent upon the plaque concentrations used to coat the indicator sheep erythrocytes.Attempts to demonstrate the receptors directly by pre-incubation of the leucocytes with high concentrations of plaque were unsuccessful in that subsequent rosette formation with plaque coated sheep erythrocytes was not inhibited.It is suggested that both antigen binding cells and mitogen binding cells are detected by the present method in proportions dependent upon the plaque concentration employed.If tolerance occurs to plaque in advanced periodontal disease, it is not due to a reduction in the number of specific antigen binding cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1981.tb00964.x
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  • 5
    Electronic Resource
    Electronic Resource
    Peripheral blood leucocytes with receptors for extracts of dental plaque (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 16 (1981), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The proportions of T and B lymphocytes, monocytes and polymorphs have been investigated in blood leucocytes expressing receptors for plaque antigens.In both patients with periodontal disease and in normal subjects, at least 95 per cent of the antigen binding leucocytes were found to be T lymphocytes. Only a mean 2 percent of the leucocytes from diseased and normal groups were B lymphocytes according to their membrane immunoglobulin. Antigen binding monocytes or polymorphs detected by phagocytosis were uncommon (a mean of 0 and 2 per cent for patients and normal subjects respectively). No differences were found between the proportions of T and B lymphocytes or phagocytic cells constituting the antigen binding leucocytes in patients or controls.There is no evidence of clonal deletion or receptor blockade of a particular subpopulalion of leucocytes amongst the antigen binding cells in severe periodontal disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1981.tb00965.x
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  • 6
    Electronic Resource
    Electronic Resource
    The in vitro cytotoxic effect of leukocytes from patients with recurrent aphthous ulceration upon mouse 3T3 fibroblasts (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 17 (1988), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study compared the in vitro cytotoxic activity against cultured NIH 3T3 mouse fibroblasts of peripheral blood leukocytes (PEL) from 13 patients with minor recurrent aphthous ulceration (RAU), 5 patients with non-aphthous oral ulceration and 23 age- and sex-matched healthy control subjects. Leukocytes from patients with RAU exerted a significantly greater degree of cytotoxicity towards the 3T3 cells than did those of control subjects. This enhanced cytotoxicity was abrogated by depletion of PEL bearing the CDS antigen (T-lymphocytes). In contrast, PEL from patients with non-aphthous oral ulceration failed to exert an enhanced cytotoxic activity against 3T3 fibroblasts, when compared to PEL from healthy control subjects. It was concluded that PEL from patients with RAU exert a significantly enhanced cytotoxicity towards an unrelated xenogeneic target cell. This activity is a specific feature of RAU and in the assay system described appears to be mediated by T-lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1988.tb01308.x
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  • 7
    Electronic Resource
    Electronic Resource
    Absence of circulating IgG immune complexes in minor recurrent aphthous ulceration (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 16 (1987), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A monoclonal rheumatoid factor binding assay has been employed to detect IgG type immune complexes in sera from 21 patients with minor recurrent aphthous ulceration and 31 control subjects. In only one of the ulcer group patients was there a marginal elevation of immune complexes above the normal range, with no statistically significant difference between the patient and control groups. Assays of intrinsic serum rheumatoid factor and serum IgG, IgM and IgA levels also showed no significant differences between patient and control groups, with all mean values falling within the normal ranges.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1987.tb00687.x
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  • 8
    Electronic Resource
    Electronic Resource
    Inflammatory cells extracted from chronically inflamed gingiva (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 14 (1979), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A method is described for separating and identifying a viable fraction of the cellular infiltrate released from specimens of inflamed gingiva by enzyme digestion. Gingiva was surgically removed from 6 patients undergoing treatment for periodontal disease. Cells released into suspension after 30, 60 and 90 minutes' incubatio with collagenase and hyaluronidase were analysed. The T lymphocyte population in the cell suspension was assayed by rosette formation with sheep erythrocytes (E) treated with S-2 Amino ethylisothiouronium bromide (E-AET). Complement receptor bearing cells (B lymphocytes and macrophages) were enumerated by rosette formation with sheep erythrocytes sensitized with IgM antibody (A) and complement (EAC). Macrophages were identified histochemically by their non-specific esterase content. The average total yield of nucleated cells extracted was approximately 1X106 per 100 mg. of gingiva. The number of contaminating erythrocytes was highest at 30 minutes. At 60 minutes' incubation there was an increase in the number of contaminating epithelial cells released into suspension. The viability of extracte cells consistently exceeded 90% in the 30 and 60 minute fractions as measured by dye exclusion but fell to between 80 and 85% after 90 minutes. The proportions of T lymphocytes found in each fraction were 81%, 72% and 64% respectively. Most of the complement receptor bearing cells were found to be macrophages, and only small numbers of B lymphocytes were identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1979.tb00246.x
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  • 9
    Electronic Resource
    Electronic Resource
    The early bacterial colonization of acrylic palates in man (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 14 (1987), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Adhesive tape applied to the fitting surface was used to study the early colonization of acrylic palates in six subjects. Streptococci were major constituents of the plaque accumulated on the tape over the first 3 days.Bacterial colonization of the tape discs was selective in that dextran-producing streptococci constituted a greater proportion of the total streptococcal count after 15 min compared with that of the initial sample and saliva, while the converse was true for Streptococcus salivarius. Scanning electron microscopy showed that denture plaque development started in grooves and depressions on the surface of the tape, and became more extensive with time. Comparison of the colonization of tape and acrylic discs in one individual demonstrated that the tape was a suitable model for in vivo colonization of dentures or orthodontic appliances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1987.tb00688.x
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  • 10
    Electronic Resource
    Electronic Resource
    Denture stomatitis: a review (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 14 (1987), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Denture stomatitis has been reported in 11–67% of complete denture wearers. It is more common on the palatal mucosa and in female patients. In Newton's type I denture stomatitis, where the inflammation remains focal, trauma seems to be responsible. In Newton's types II and III denture stomatitis, where the denture-bearing mucosa is diffusely involved, most workers assert that the aetiology is multi-factorial. Evidence is presented incriminating Candida albicans colonization of the fitting surface of the prosthesis in many cases of denture stomatitis promoted by continuous denture wearing. Allergic and primary irritant reactions to the denture base material, systemic predisposing factors including dietary deficiency and haematological disorders, also play a part. In most cases of denture stomatitis, elimination of denture faults, control of denture plaque and discontinuous denture wearing are sufficient treatment. The routine use of antiseptic or antimycotic drugs seems unnecessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1987.tb00713.x
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