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  • 1
    Electronic Resource
    Electronic Resource
    Fast-scan magnetic resonance imaging of fetal anomalies (1991)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 98 (1991), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective— To identify those congenital fetal anomalies, previously identified by ultrasound scanning, in which fast-scan magnetic resonance imaging (F-SMRI) would give additional information for the perinatal management of the infants.Design— Observational clinical study.Setting— Hospital Department of Obstetrics and Gynaecology/Resonance Research Centre.Subjects— Seven women carrying eight fetuses in whom congenital abnormal-ities had been identified using ultrasound scans. The duration of the pregnancies was 28 to 39 weeks gestation.Interventions— Fast-scan magnetic resonance imaging at between 28 and 39 weeks gestation.Main outcome measures— Identification of fetal abnormalities.Results and conclusions— F-SMRI was of limited value in the diagnosis of further assessment of fetuses with abnormalities of accumulation of tissue fluid. Renal anomalies were poorly identified unless associated with cystic formation of the kidney. Further study is required in the imaging of fetal central nervous system anomalies. Until echoplanar imaging is more widely available, MRI does not contribute to the diagnosis of cardiac anomalies. F-SMRI appears to be most useful in the diagnosis and management of soft tissue gastro intestinal abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1991.tb15392.x
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  • 2
    Electronic Resource
    Electronic Resource
    Perinatal events which precede periventricular haemorrhage and leukomalacia in the newborn (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Ultrasound brain scans were obtained daily for the first 5 days after birth, on day 7 and then weekly until discharge from hospital in 86 babies during a 12-month period. The babies weighed 〈1501 g or were 〈34 weeks gestational age. Fifty-one (59%) had normal scans. 34 (40%) developed periventricular haemorrhage, and seven (8%) developed periventricular cysts (associated with periventricular haemorrhage in six). Factors associated with periventricular haemorrhage were perinatal hypoxia, acidosis, hypercapnia and hypoxia after birth. Babies who developed periventricular cysts (periventricular leukomalacia) were more likely to have been hypoxic at birth and in four of the seven there had been a maternal antepartum haemorrhage. The association of perinatal hypoxia with periventricular haemorrhage and leukomalacia suggests that intraparturm events may predispose to the onset of these lesions which then develop postnatally. Prevention of perinatal hypoxia may play an important role in diminishing the disability caused by these conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb04865.x
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  • 3
    Electronic Resource
    Electronic Resource
    Ureaplasma urealyticum and chronic lung disease (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 931-932 
    Details
    ISSN: 1432-1076
    Keywords: Ureaplasma urealyticum ; Chronic lung disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neonatal lower respiratory tract colonisation with mycoplasma organisms was examined for an association with chronic lung disease.Ureaplasma urealyticum colonised 9/70 (13%) infants less than 1500 g. Seven (78%) colonised and 33 (54%) non-colonised infants developed chronic lung disease. Logistic regression analyses revealed early gestation, but not mycoplasma colonisation, was independently associated with chronic lung disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957534
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  • 4
    Electronic Resource
    Electronic Resource
    Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: The effects of dichloroacetate (DCA) (1983)
    Springer
    European journal of pediatrics 141 (1983), S. 114-117 
    Details
    ISSN: 1432-1076
    Keywords: Hyperinsulinaemic hypoglycaemia ; Transient lactic acidaemia ; Dichloroacetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Soon after birth a 36-weekgestational age, appropriate for dates, newborn infant developed hyperinsulinaemic hypoglycaemia which responded to diazoxide and glucose infusion. While normoglycaemic, he became increasingly ill with high lactate, pyruvate, and alanine levels. Provocation tests suggested a defect in lactate handling. Dichloroacetate (DCA) was given and resulted in the prompt normalisation of his metabolic profile with no recurrence after discontinuation of the drug. A second episode of hyperinsulinaemic hypoglycaemia followed and this was controlled satisfactorily by short term diazoxide treatment. Diazoxide treatment could be stopped at the age of 1 month. Although at the age of 1.5 years the infant is retarded developmentally, there has been no recurrence of lactic acidosis nor hyperinsulinaemic hypoglycaemia. The association of lactic acidosis and hyperinsulinism, and the use of DCA in this circumstance have not been reported previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496802
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  • 5
    Electronic Resource
    Electronic Resource
    Neonatal intracranial lesions following placental abruption (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 195-197 
    Details
    ISSN: 1432-1076
    Keywords: Key words: Infant, newborn – Abruptio placentae – Ultrasonic diagnosis – Cerebral haemorrhage – Encephalomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A case-controlled study of the cerebral ultrasound appearances of neonates following placental abruption was undertaken. Twenty-nine index subjects (median gestation 29 weeks) were identified over a 2-year period with gestation- and sex-matched controls. Placental abruption was associated with a four-fold increased incidence of periventricular leukomalacia and extensive periventricular haemorrhage, without increased mortality. Ten infants (34%) developed cystic periventricular leukomalacia following placental abruption, compared with three (10%) in the control group. Intraventricular haemorrhage (excluding subependymal haemorrhage) and haemorrhage into the brain parenchyma occurred in 21 (72%) infants in the abruption group, compared with 14 (48%) in the control group (P〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958985
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  • 6
    Electronic Resource
    Electronic Resource
    Neonatal intracranial lesions following placenta abruption (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 195-197 
    Details
    ISSN: 1432-1076
    Keywords: Infant, newborn ; Abruptio placentae ; Ultrasonic diagnosis ; Cerebral haemorrhage ; Encephalomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case-controlled study of the cerebral ultrasound appearances of neonates following placental abruption was undertaken. Twenty-nine index subjects (median gestation 29 weeks) were identified over a 2-year period with gestation-and sex-matched controls. Placental abruption was associated with a fourfold increased incidence of periventricular leukomalacia and extensive periventricular haemorrhage, without increased mortality. Ten infants (34%) developed cystic periventricular leukomalacia following placental abruption, compared with three (10%) in the control group. Intraventricular haemorrhage (excluding subependymal haemorrhage) and haemorrhage into the brain parenchyma occurred in 21 (72%) infants in the abruption group, compared with 14 (48%) in the control group (P〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958985
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  • 7
    Electronic Resource
    Electronic Resource
    The apparent role of blood transfusions in the development of retinopathy of prematurity (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 833-836 
    Details
    ISSN: 1432-1076
    Keywords: Retinopathy of prematurity ; Blood transfusion ; Newborn ; Cryotherapy ; Prematurity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract During a 30-month-period, 184 very low birth weight infants from two Liverpool neonatal intensive care units were screened for evidence of retinopathy of prematurity (ROP). Seventeen clinical variables previously considered relevant to the development of ROP, blood gas and blood pressure data over the first 7 days, and the maximum stage of ROP reached in either eye were recorded, together with the need for cryotherapy and current visual status. Ninety-two infants developed any stage of ROP and 15 required cryotherapy or became blind. Logistic regression showed that only gestational age and frequency of blood transfusion were independently associated both with the risk of occurrence of ROP and its severity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02073381
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  • 8
    Electronic Resource
    Electronic Resource
    Dichloroacetate in the treatment of congenital lactic acidosis (1984)
    Springer
    Journal of inherited metabolic disease 7 (1984), S. 26-26 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805616
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  • 9
    Electronic Resource
    Electronic Resource
    Use of digital techniques to process cerebral electrical impedance signals in the newborn (1984)
    Springer
    Medical & biological engineering & computing 22 (1984), S. 55-62 
    Details
    ISSN: 1741-0444
    Keywords: Cerebral blood flow ; Impedance plethysmography ; Intraventricular haemorrhage ; Microcomputer ; Neonates ; Signal processing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Electrical impedance measurements can provide much useful information on cerebral haemodynamics in ill newborn infants. However, the analysis of the pusatile impedance signal presents a number of problems. These are due to the electrical noise generated by other monitoring equipment in the neonatal intensive care unit, the presence of a strong breathing component within the impedance signal and frequent movement artefacts. Algorithms based on techniques such as digital filtering, coherent averaging and template matching have been developed to deal with these problems. The continuous analysis of the pulsatile impedance waveforms to be carried out automatically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443746
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of electrode size on the contributions of intracranial and extracranial blood flow to the cerebral electrical impedance plethysmogram (1982)
    Springer
    Medical & biological engineering & computing 20 (1982), S. 545-549 
    Details
    ISSN: 1741-0444
    Keywords: Cerebral blood flow ; Impedance plethysmography ; Photoplethysmography ; Rheoencephalography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The contribution of scalp blood flow to pulses obtained by cerebral electrical impedance plethysmography (rheoencephalography) has been investigated using a four-electrode (quadripolar) montage with brass disc electrodes 1 cm, 2 cm and 4 cm in diameter. Three states of scalp perfusion were produced by the application of a tourniquet around the occipto-frontal circumference of the head, and blood flow in the scalp was monitored by means of reflection photoplethysmography and an electrical impedance technique. When scalp perfusion was occluded, cerebral impedance pulse amplitude was reduced to 80% of that obtained during normal scalp flow; in the presence of maximal scalp flow as a result of the reactive hyperaemia induced by release of the tourniquet, cerebral impedance pulse amplitude was 30% greater than during normal scalp flow. Altering electrode diameter did not affect the contribution of scalp flow to cerebral impedance pulse size. The effect of changes in scalp flow did, however, increase when a bipolar electrode montage was used instead of a quadripolar montage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443401
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