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  • 1
    Electronic Resource
    Electronic Resource
    The Synaptinemal Complex (1972)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 6 (1972), S. 71-110 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ge.06.120172.000443
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Alterations in specific signal transduction pathways may explain the hyperproliferation and abnormal differentiation of the keratinocytes as well as the increased expression of inflammatory cytokines seen in psoriasis. Major signalling pathways used by eukaryotic cells to transduce extracellular signals into cellular responses impinge on the mitogen-activated protein kinases (MAPKs).Objectives  To investigate the expression of the MAPK p38, extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK) in psoriatic skin.Methods  Keratome biopsies were taken from patients with plaque-type psoriasis. Western blot analysis was used to determine p38, ERK and JNK activity and protein levels, whereas kinase assays were used to examine the kinase activity of p38.Results  We demonstrated increased levels of the phosphorylated forms of p38 and ERK1/2 in lesional psoriatic skin compared with nonlesional psoriatic skin. No abnormality was found in the activation and expression of JNK1/2. Ex vivo kinase assays confirmed the increased activation of p38, and furthermore demonstrated increased kinase activity of the p38 isoforms p38α, p38β and p38δ in lesional compared with nonlesional psoriatic skin. p38γ was not detected in the psoriatic skin. Clearance of the psoriatic lesions, induced by climatotherapy at the Dead Sea for 4 weeks, led to a normalization in the activity of both p38 and ERK1/2.Conclusions  Taken together, our results demonstrate that the activity of the MAPKs p38α, p38β and p38δ and ERK1/2 are increased in lesional psoriatic skin compared with nonlesional psoriatic skin, and that clearance of psoriasis normalizes the p38 and ERK1/2 activity. Thus, p38 and ERK1/2 might be potential targets in the treatment of psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.06304.x
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  • 3
    Electronic Resource
    Electronic Resource
    Validity of the Neurospora Back-Mutation Test (1952)
    [s.l.] : Nature Publishing Group
    Nature 169 (1952), S. 626-626 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On the basis of this observation, the validity of the Neurospora back-mutation test for investigating the mutagenic effect of chemical and physical agents is questioned. This test has been used in our laboratory, and in a number of other laboratories, in recent years for studying the mutagenic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/169626a0
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  • 4
    Electronic Resource
    Electronic Resource
    Induced Tetraploidy in Melandrium album (1938)
    [s.l.] : Nature Publishing Group
    Nature 142 (1938), S. 917-917 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the flowering plants, the problem of polyploidy in relation to diœcism is an extraordinarily attractive one, since it should be possible in this way to get additional proof of the balance theory of sex determination. So far, experimentally produced polyploids have not been described in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/142917b0
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  • 5
    Electronic Resource
    Electronic Resource
    Chemical mutagenesis in relation to the concept of the gene (1957)
    Springer
    Cellular and molecular life sciences 13 (1957), S. 224-234 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die vorliegende Arbeit gibt einen Überblick über neuere Untersuchungen chemischer Mutationsauslösungen mit besonderer Betonung der Induktion von Chromosomenbrüchen in Pflanzen und Rückmutationen beiNeurospora. Die Arbeit zeigt, dass jedes Allel ein charakteristisches Mutationsverhalten zeigt, das durch die Reaktion auf physikalische und chemische Mutagene definiert wird. Diese Ergebnisse werden unter dem Aspekt diskutiert, dass ein Gen die Einheit der Funktion, Rekombination und Mutation darstellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02157427
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  • 6
    Electronic Resource
    Electronic Resource
    Biological Action of ‘Mustard Gas’ Compounds: Mutagenic Activity of some ‘Mustard Gas’ Compounds (1950)
    [s.l.] : Nature Publishing Group
    Nature 166 (1950), S. 1020-1021 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE problem of the chemical mechanism involved in the mutagenic activity of the mustard gases has been approached by some experiments with mono-chloro- and dichloro- nitrogen mustards which have been carried out in our Laboratories. The mutagenic activity was tested by means of the Neurospora ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1661020a0
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  • 7
    Electronic Resource
    Electronic Resource
    Über den Mechanismus der Geschlechtsbestimmung bei Melandrium album (1953)
    Springer
    Naturwissenschaften 40 (1953), S. 253-260 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00590417
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    Paper (German National Licenses)
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