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  • 1
    Electronic Resource
    Electronic Resource
    Structure and Biology of the Globular Domain of Basement Membrane Type IV Collagen (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 460 (1985), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1985.tb51157.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Autoimmune and Inflammatory Mechanisms in Atherosclerosis (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 22 (2004), S. 361-403 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: The present review focuses on the concept that cellular and humoral immunity to the phylogenetically highly conserved antigen heat shock protein 60 (HSP60) is the initiating mechanism in the earliest stages of atherosclerosis. Subjecting arterial endothelial cells to classical atherosclerosis risk factors leads to the expression of HSP60 that then may serve as a target for pre-existent cross-reactive antimicrobial HSP60 immunity or bona fide autoimmune reactions induced by biochemically altered autologous HSP60. Endothelial cells can also bind microbial or autologous HSP60 via Toll-like receptors, providing another possibility for targetting adaptive or innate immunological effector mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.immunol.22.012703.104644
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Autoimmune and Inflammatory Mechanisms in Atherosclerosis (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 22 (2004), S. 361-403 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: The present review focuses on the concept that cellular and humoral immunity to the phylogenetically highly conserved antigen heat shock protein 60 (HSP60) is the initiating mechanism in the earliest stages of atherosclerosis. Subjecting arterial endothelial cells to classical atherosclerosis risk factors leads to the expression of HSP60 that then may serve as a target for pre-existent cross-reactive antimicrobial HSP60 immunity or bona fide autoimmune reactions induced by biochemically altered autologous HSP60. Endothelial cells can also bind microbial or autologous HSP60 via Toll-like receptors, providing another possibility for targetting adaptive or innate immunological effector mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.immunol.22.012703.104644
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Autoimmune and Inflammatory Mechanisms in Atherosclerosis (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 22 (2004), S. 361-403 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: The present review focuses on the concept that cellular and humoral immunity to the phylogenetically highly conserved antigen heat shock protein 60 (HSP60) is the initiating mechanism in the earliest stages of atherosclerosis. Subjecting arterial endothelial cells to classical atherosclerosis risk factors leads to the expression of HSP60 that then may serve as a target for pre-existent cross-reactive antimicrobial HSP60 immunity or bona fide autoimmune reactions induced by biochemically altered autologous HSP60. Endothelial cells can also bind microbial or autologous HSP60 via Toll-like receptors, providing another possibility for targetting adaptive or innate immunological effector mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.immunol.22.012703.104644
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 160 (1997), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: The function of the immune system declines with age. It is the aim of the present review to demonstrate that it makes sense to distinguish between primary and secondary alterations of immune reactivity in the elderly. Primary changes occur as the result of an age-dependent intrinsic decline of immune responsiveness. They also occur in healthy persons, i.e. persons, selected according to the criteria of the SENIEUR protocol of the European Community's Concerted Action Program on Aging (EURAGE). T lymphocytes are hereby more severely affected than B cells or antigen presenting cells, possibly due to the involution of the thymus, which is almost complete at the age of 60. Secondary immunological changes occur as the result of environmental factors including diet, drug intake, physical activity etc. or arc alternatively due to underlying diseases. In this article, the effects of high lipid intake as well as the impact of diseases, such as for instance Alzheimer's disease and atherosclerosis, will be addressed. The results underline the complexity of immunological alterations to be expected in old age. Changes in the aging immune system represent an opportunity for increased frequency and severity of disease and endanger the protective effect of vaccination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1997.tb01037.x
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  • 6
    Electronic Resource
    Electronic Resource
    The Decline of the Immune Response during Aging: the Role of an Altered Lipid Metabolism (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 621 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb16986.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    No immunity for the elderly (1998)
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 870-870 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To the editor—Nature Medicine's recent supplement on vaccines (Volume 4, pages 472–534 May 1998) is timely and certain to stimulate public and research interest in vaccinology. However, the problem of vaccination of the elderly was not addressed. Although the impact of childhood ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0898-870b
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Proportional increase of bursa-derived cells in chickens of the Obese strain (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 653-654 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The major issue in research on autoimmune diseases is the question whether a primary autoantigenic stimulation (for example, by antigenically altered autologous material) of an essentially normal immune system leads to the development of disease, or if an abnormal immune system is incapable of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249653a0
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  • 9
    Electronic Resource
    Electronic Resource
    “Natural” chicken antibodies to red blood cells are mainly directed against the B-G antigen, and their occurrence is independent of spontaneous autoimmune thyroiditis (1984)
    Springer
    Immunogenetics 19 (1984), S. 269-277 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using an indirect hemagglutination assay we tested sera from 94 healthy normal White Leghorn (NWL) and 117 Obese strain (OS) chickens with spontaneous autoimmune thyroiditis for the presence of “natural” antibodies against major histocompatibility complex (MHC) antigens expressed on red blood cells (RBC). In both groups older animals had a significantly increased frequency of such antibodies, but the titer was age-independent. OS chickens showed almost the same frequency of natural antibodies as NWL, and a comparison between OS birds with high antithyroglobulin autoantibody (Tg-AAb) titers and those with low titers also did not reveal a significant difference. We conclude that the occurrence of natural antibodies has no relation to Tg-AAb. The specificity of natural antibodies for MHC-encoded antigens was investigated in indirect immunofluorescence tests including absorption experiments with RBC and white blood cells (WBC). This analysis revealed that of 14 MHC-specific sera 13 were reacting with the B-G antigen, which is present on RBC only. One serum reacted with the B-F antigen, expressed on all somatic cells, i. e., both on RBC and WBC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345400
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  • 10
    Electronic Resource
    Electronic Resource
    Antifading embedding media in confocal immunoflourescence microscopy (1993)
    Springer
    Journal of fluorescence 3 (1993), S. 173-178 
    Details
    ISSN: 1573-4994
    Keywords: Immunofluorescence ; bleaching ; laser scanning microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Fading or bleaching of fluorescence intensity during continuous illumination of stained objects is a serious problem in fluorescence microscopy. Fluorescence intensity as well as bleaching characteristics of dyes are dependent primarily upon physical parameters such as molecular constants (absorption rate and quantum efficiency), excitation energy and brightness (causes photon saturation), and environmental parameters (pH, ions, binding to proteins, etc.) that can strongly influence the properties of fluorochrome molecules. We have studied the effect of various antifading reagents on the behavior of the common dyes fluorescein isothiocyanate (FITC) and phycoerythrin (PE) using immunofluorescent-stained living cells in suspension or membrane-permeabilized dried cells as test systems. As expected, fading cannot be completely eliminated but may be reduced to varying degrees. In our hands, the most efficient antifading reagent for FITC isn-propyl gallate (NPG) dissolved in glycerol. No additive was found to retard fading, but complete dehydration of the cell suspension reduces this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00862738
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