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HLA-DRB1 Alleles Contribute to Determining the Prognosis of Japanese Diabetes Mellitus Positive for Antibodies to Glutamate Decarboxylase (1998)

Fukui, Michiaki ; Nakano, Koji ; Nakamura, Naoto ; [et al.]

Springer

Journal of clinical immunology 18 (1998), S. 89-92

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ISSN: 1573-2592

Keywords: HLA-DRB1 ; antibodies to glutamate decarboxylase ; insulin-dependent diabetes mellitus ; non-insulin-dependent diabetes mellitus ; secondary failure of sulfonylurea agents

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Diabetes mellitus positive for antibodies to glutamate decarboxylase is heterogeneous as far as the degree of impairment of endogenous insulin release, though antibodies to glutamate decarboxylase are the most useful marker for future insulin deficiency. To investigate what determines the prognosis of diabetes mellitus positive for antibodies to glutamate decarboxylase, we measured HLA-DRB1 alleles in three groups: 77 cases of insulin-dependent diabetes mellitus (IDDM), 44 of non-insulin-dependent diabetes mellitus (NIDDM) with secondary failure of oral hypoglycemic therapy, and 22 of NIDDM well controlled by diet and/or sulfonylurea agents. The proportion of susceptible and resistant alleles to IDDM determined the degree of insulin deficiency, and comparison of IDDM to NIDDM well controlled by diet and/or sulfonylurea agents revealed significant differences in DRB1*0405 (P 〈 0.05; RR = 2.82 and RR = 0.89, respectively) and DRB1*1502 (P 〈 0.001; RR = 0.02 and RR = 2.19, respectively). This study revealed that HLA-DRB1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1023248106674

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The outer arm dynein α-heavy chains of sea urchin sperm flagella and embryonic cilia are different (1990)

Ogawa, Kazuo ; Yokota, Etsuo ; Hamada, Yoshio ; [et al.]

New York, NY : Wiley-Blackwell

Cell Motility and the Cytoskeleton 16 (1990), S. 58-67

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ISSN: 0886-1544

Keywords: subunit composition ; Western blotting ; monoclonal antibody ; affinity-purified polyclonal antibody ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: Sea urchin sperm outer arm dynein is a multi-subunit protein composed of heavy chains, intermediate chains, and light chains. We prepared monoclonal and affinity-purified polyclonal antibodies to heavy and intermediate chain subunits and examined whether the embryonic ciliary axonemes ofthe same species contain the polypeptides sharing epitopes with them. Ciliary axonemes contained a high molecular weight polypeptide with the exact same mobility as flagellar β-heavy chain. This polypeptide also shared epitopes with it. In contrast, no polypeptide had the exact same molecular weight as flagellar α-heavy chain and shared epitopes with it. Western blots showed that ciliary axonemes also contain three polypeptides sharing epitopes with the respective flagellar intermediate chain. The present results revealed that the α-heavy chains of flagellar and ciliary outer arm dyneins are different.

Additional Material: 6 Ill.