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  • 1
    Electronic Resource
    Electronic Resource
    In vivo autoradiographic analysis of prolactin binding in brain and choroid plexus of the domestic ring dove (1988)
    Springer
    Cell & tissue research 251 (1988), S. 105-109 
    Details
    ISSN: 1432-0878
    Keywords: Prolactin ; Receptor ; Autoradiography ; Choroid plexus ; Domestic ring dove
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The binding of intravenously administered prolactin to choroid plexus and brain tissue was determined radioautographically in the ring dove, a species that exhibits prolactin-induced alterations in brain function. An intense autoradiographic reaction was detected over the epithelial cells of the choroid plexus 5 min after the intravenous injection of 125I-ovine prolactin. A significant reaction was also observed over the infundibulum but no significant uptake of prolactin occurred in other brain areas. The binding of radiolabelled prolactin to infundibulum appeared to be non-specific, since excess unlabelled hormone did not reduce silver grain density. In contrast, 125I-ovine prolactin binding in choroid plexus was significantly reduced by excess unlabelled ovine prolactin or human growth hormone, but not by ovine luteinizing hormone. Specific binding to choroid plexus was also detected in vitro. The lack of significant brain uptake of prolactin in vivo is discussed in relation to recent in vitro evidence for specific binding sites for prolactin in several dove brain regions. Similarities between the binding results obtained in this avian species and those reported previously in mammals suggest that the two vertebrate groups exhibit similar patterns of prolactin interaction with neural target tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215453
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of specific substance P binding sites in the heart and adjacent great vessels of the Wistar white rat (1996)
    Springer
    Cell & tissue research 284 (1996), S. 495-500 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Substance P ; Receptors ; membrane ; Heart ; Binding sites ; Aorta ; Valves ; Neuropeptide immunocytochemistry ; Magnesium ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Magnesium(Mg)-deficiency, whether dietary or an effect of a clinical condition such as diabetes, results in a variety of cardiovascular pathologies. Substance P (SP) has been implicated in the induction of cardiac focal inflammatory lesions that occur during Mg-deficiency. Blockade of SP receptors results in a significant reduction in the incidence of lesion formation. In an effort to identify potential endogenous cell populations of the heart, which may play a role in SP-dependent lesion formation, film- and light-microscopic autoradiography were used to map the distribution of specific SP binding sites in frozen sections of the normal rat heart and adjacent great vessels. Binding was assessed with 0.1 nM I-125 Bolton-Hunter labelled SP in the absence (total binding) or presence (non-specific binding) of excess unlabelled SP, prolactin, or L-703,606, a non-peptide antagonist of SP receptors. Film autoradiograms revealed prominent small foci of intense autoradiographic reactions dispersed intermittently around the periphery of the great vessels and coronary arteries, among the interstitial connective tissue of the heart, and along the cusps of the cardiac valves. Excess unlabelled SP caused a significant reduction (97.7% displacement; P〈0.001) in the focal autoradiographic reactions. L-703,606 caused a similar reduction in SP binding (97.3% displacement; P〈0.001), while prolactin had no statistically significant effect on the binding of radiolabelled SP. Light-microscopic autoradiograms revealed that the SP binding sites occurred within clusters of connective tissue cells or in rarely observed parasympathetic ganglia. No evidence was found to suggest the presence of SP receptors on endothelial cells, cardiac muscle fibers, or smooth muscle fibers. The connective tissue cells which bound SP within the heart will likely include types that are susceptible to SP activation and thus may play a role in initiation of the focal inflammation characteristic of Mg-deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050611
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  • 3
    Electronic Resource
    Electronic Resource
    Supraependymal cells in the third ventricle of the neonatal rat (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 190 (1978), S. 257-269 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Supraependymal cells in the third ventricle of neonatal male and female rats were examined with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Supraependymal cells in the third ventrical of adult male rats were also studied with SEM. Many neonate supraependymal cells were round to oval in shape and exhibited varying degrees of surface irregularity. Small finger-like processes or narrow pseudopodia projected from the cell bodies over the underlying ependymal cells. Some neonatal supraependymal cells exhibited flattened cell bodies with broad pseudopodia and few surface irregularities. TEM revealed a variety of cell profiles. Prominent within the cytoplasm of many supraependymal cells were lysosomes, smooth and coated vesicles suggesting pinocytosis, subplasmalemma vacuoles, and occasional lipid droplets. The morphological characteristics of neonatal supraependymal cells suggested they were mononuclear phagocytes. Adult supraependymal cells exhibited more pleomorphic cell shapes with numerous cell processes, varying widely in size and shape, and often extending over the ventricular surface for considerable distances. These observations, in combination with previous studies by other investigators, suggest that some adult supraependymal cells may also be phagocytic in nature. The differences in morphology between adult and neonatal supraependymal phagocytes may relate to the differing third ventricle environment between adult and neonates and/or differences in the origin of the phagocytes with age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091900209
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  • 4
    Electronic Resource
    Electronic Resource
    Prolactin causes increased turnover of dopamine in 10-day-old rat median eminence (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 217 (1987), S. 53-55 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The present work examines the ability of prolactin to enter the CNS of the rat and effect its feedback stimulation of dopamine release prior to the appearance of prolactin receptors in choroid plexus (i.e., 10 days postnatal). An inhibitor of tyrosine hydroxylase was used to allow the assessment of dopamine turnover separate from synthesis and transport of the amine. Chronic but not acute hyperprolactinemia resulted in increased dopamine release relative to vehicle-treated controls, as shown by diminished fluorescence intensity in the median eminence. These results indicate that activation of the prolactin short-loop feedback system occurs by 10 days postnatal, prior to the appearance of prolactin receptors at the choroid plexus.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092170108
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  • 5
    Electronic Resource
    Electronic Resource
    Early postnatal development of ependyma in the third ventricle of male and female rats (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 151 (1978), S. 377-407 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Ependyma in the third ventricle of developing male and female rats (0, 5, and 10 days postpartum) were compared with those of sexually mature male rats by means of scanning electron microscopy (SEM) and transmission electron microscopy (TEM). No sexual dimorphism appeared in the developmental group. At all ages the dorsolateral ventricular wall was composed of ciliated ependymal cells, while ependymal cells of the ventrolateral wall exhibited apical microvilli and bleb-like irregularities.While SEM revealed similarities in apical morphology between ependymal cells of adult and developing animals, TEM revealed marked differences between these cells. Many ciliated ependymal cells in developing animals resembled those of the adult while other neonatal cell profiles suggested ciliogenesis.Adult male rats exhibited two distinct tanycyte populations. One population, characterized by elaborate intercellular interdigitations and basal processes containing predominantly fine filaments, occurred adjacent to the ventromedial nucleus (VMN). The second population, characterized by less extensive intercellular interdigitations and basal processes containing, primarily microtubules, lined the roof of the lateral recess adjacent to the arcuate nucleus. Many tanycytes at the level of the arcuate nucleus in developing rats resembled closely those of the adult. In contrast, developing ependymal cells at the level of the VMN differed from their adult counterparts in that they exhibited little intercellular interdigitation and projected basal processes characterized by an internal framework of microtubules.Similarities in cytology between developing and adult tanycytes of the arcuate region suggest that the adult function of this population may be operative in the early postnatal period. In contrast, the differing cytology between adult and developing tanycytes of the VMN region suggests that the function of these cells is age-dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001510305
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  • 6
    Electronic Resource
    Electronic Resource
    Response of tanycytes to aging in the median eminence of the rat (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 163 (1982), S. 247-256 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Age-related changes in tanycytes of the median eminence were observed at both the light and electron microscopic level in male and female rats at ages 4 weeks to 14 months. The most obvious changes involved a marked progressive increase in number and size of droplets identified histochemically as neutral lipid and the development of complex degenerate bodies in the perivascular contact zone. These degenerate bodies consisted of large multiple complexes of myelin figures containing intercalated channels and pools of electron-dense material. They often occurred interspersed among large lipid droplets. The degenerate bodies (myelin figure complexes) and associated lipid droplets occupied much of the contact zone in the older animals. Evidence of axonal degeneration and tanycytic phagocytosis of deteriorating neural elements was also present. These age-related changes occurred independent of sex and were not affected by gonadectomy. This tanycyte response to aging in the median eminence is very similar to the response of neurohypophysial pituicytes to axonal degeneration, suggesting a phagocytic glial role for tanycytes.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001630305
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