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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 17 (1970), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Human brain-specific alpha2-glycoprotein was purified by means of Sepharose immunoadsorbents. A further brain-specific protein was found by this method. This component appears to be present in brain in low concentrations only and has been enriched by affinity chromatography. Glial cells of human brain were separated from neurons by a density centrifugation method and four fractions were obtained: neuropil, neuronal perikarya, nuclei and debris. Each fraction was checked by light and phase contrast microscopy to estimate the intactness of the cells and any contamination by other fractions, and also immunologically for determination of brain-specific alpha2-glyco-protein. The results indicate that localization of this brain-specific protein is in the cyto-plasm of the glial cells. The results are discussed in terms of a possible role of this protein in the inflammatory response and in some demyelinating diseases.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 370 (1976), S. 233-238 
    ISSN: 1432-2307
    Keywords: Gallbladder ; Malignant melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A primary malignant melanoma of the gallbladder in a 44-years-old man is presented. The typical pathologic findings in the now eight reported cases are analysed. The clinical course of the present case was determined by multiple metastases to the brain. The histogenesis of these rare tumors of the gallbladder is still obscure.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 102-105 
    ISSN: 1433-8491
    Keywords: Nerve conduction velocity ; Polyneuropathy ; Pyridoxine deficiency ; Rat pellagra ; SEP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Whilst 22 male Wistar rats were fed on a pyridoxine-deficient diet for 26 weeks, 22 controls received a normal diet. The vitamin B6 deficient animals lost no weight but they developed symptoms of rat pellagra. The sensory nerve conduction velocity, the compound radicular, spinal and brain stem responses and the SEP were derived following tail and hind paw stimulation. The examination was repeated at 6 week intervals. A disturbed central stimulus conduction was indicated by the delayed SEP and intracerebral conduction times. An impairment of neurotransmitter metabolism may be of importance in this case. Considering related data the results implicate the importance of vitamin B6 substitution in the case of CNS disturbances due to malnutrition, e.g., chronic alcoholism. The nerve conduction velocity decreases subsequently. A disturbance of myelin function is indicated in adult rats under conditions of pyridoxine deficiency.
    Type of Medium: Electronic Resource
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