Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
23 (1974), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract— Synaptosomes prepared by differential and Ficoll density gradient centrifugation took up d-galactose by two saturable transport systems: one. a high affinity system with a Km of 0-25 mn and Vmax of 075 nmol/mg protein 3 min, the other, a low affinity system with a Km of 47 mM and a Vmaxof 135 nmol/mg protein/3 min. The high affinity system was inhibited by 1-5 mM phlorizin but was unaffected by the absence of sodium ion or the presence of 1 mM ouabain. The low affinity system was unaffected by phlorizin or ouabain. Both systems were inhibited by high concentrations of glucose. 2-deoxyga-lactose. and inositol, and by 2.4-dinitrophcnol. Galactose was rapidly converted in synaptosomes to phos-phorylatcd intermediates and was more slowly oxidized to 14CO2
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1974.tb12211.x
Permalink
Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |