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  • 1
    Electronic Resource
    Electronic Resource
    Atrial natriuretic factor in patients with acromegaly (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 409-413 
    Details
    ISSN: 1432-1041
    Keywords: atrial natriuretic factor (ANF) ; acromegaly ; volume expansion ; plasma levels ; extracellular fluid volume ; saline load
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In acromegaly the plasma volume is chronically elevated and it returns to normal when the disease is successfully treated. To define the role of ANF in such a chronic disorder of extracellular fluid volume homeostasis the plasma level was assayed in 37 acromegalic patients with active or inactive (successfully treated) disease. Five patients were studied before and after therapy. The effects of acute change in sodium-fluid status on plasma ANF levels was examined in 7 active and 4 inactive acromegalic patients and in 7 healthy subjects. As compared to 14 patients with inactive acromegaly, 23 patients with active acromegaly had an expanded plasma volume (n=12; 50.1 vs 37.6 ml · kg−1 BW) and an increased blood concentration of growth hormone (n=23; 22.5 vs 2.1 ng · ml−1). Plasma ANF concentrations in active and inactive acromegalic patients (33.2 and 26.6 pg · ml−1, respectively) did not differ significantly from one another or from the level in the controls (26.9 pg · ml−1). In those patients there was no correlation between plasma volume and ANF level. Infusion of 21 isotonic saline in 2 h led to a similar, significant increase in ANF levels in active (from 26.2 to 72.4 pg · ml−1) and in inactive acromegalic patients (from 33.6 to 96.7 pg · ml−1) as well as in healthy subjects (from 21 to 70.6 pg · ml−1). Successful treatment reduced the plasma volume (from 49.2 to 35.8 ml · kg−1 BW) and growth hormone level (from 10.1 to 2.6 pg · ml−1), while the ANF level remained unchanged (from 33.8 to 35.5 pg · ml−1). In the patients with active or inactive acromegaly and cardiac failure the plasma ANF level was markedly increased (89.9 and 66.1 pg · ml−1, respectively) as compared to all the other groups. It is concluded that ANF levels are not elevated in chronically volume expanded acromegalic patients. In the present patients ANF was released in response to acute volume expansion, therefore it may be important in the cardiovascular and renal response to acute changes in extracellular fluid volume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336675
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Somatostatin receptor imaging in non-functioning pituitary adenomas: value of an uptake index (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 647-650 
    Details
    ISSN: 1619-7089
    Keywords: Somatostatin receptor imaging ; Pituitary scintigraphy ; Non-functioning adenomas ; Somatostatin analogues ; Indium-111 pentetreotide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Somatostatin receptor imaging (SRI) was performed in five patients with known non-functioning pituitary adenomas. To determine whether the pituitary uptake correlates with response to octreotide therapy, an uptake index (UI) was calculated. Pituitary adenomas were detected in all five patients. The UI was, respectively, 15.1, 3.7, 2.2, 2.2 and 2.2 (the UI calculated in 12 normal subjects was between 1 and 1.9). Only the patient with the highest Ul (15.1) had a dramatic improvement in tumour volume and visual function in response to octreotide therapy. The Ul might be a good predictive parameter of octreotide therapy efficacy in non-functioning adenomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285587
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of octreotide on biliary lipid composition and occurrence of cholesterol crystals in patients with acromegaly (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 2384-2388 
    Details
    ISSN: 1573-2568
    Keywords: somatostatin ; gallstones ; bile acids ; phospholipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treatment with the somatostatin analog octreotide is associated with increased gallstone formation. The mechanism of formation of these stones is unclear. The purpose of this study was to examine the effect of a three-month treatment with octreotide on biliary lipid composition and the occurrence of cholesterol crystals in patients with acromegaly. Thirteen patients with active acromegaly, aged 24–76 years, received octreotide (100 µg three times daily) for three months. Fasting gallbladder bile was obtained during upper gastrointestinal endoscopy after ceruletide stimulation. Bile was studied before and at the end of the treatment period (N=7), only before (N=4), or only at the end of treatment (N=2). Before treatment, all bile samples but one were supersaturated with cholesterol. However, none contained cholesterol crystals on microscopic examination. At the end of the treatment period, all but two samples were supersaturated with cholesterol. Three of nine samples contained cholesterol crystals, a proportion significantly higher than before treatment. The relative proportions of bile acids, cholesterol, and phospholipids, and the mean cholesterol saturation index were not different before and during treatment. Follow-up ultrasonography showed the occurrence of gallstones in four patients, including the three patients who had cholesterol crystals. We conclude that: (1) fasting gallbladder bile of patients with acromegaly is frequently supersaturated with cholesterol; (2) treatment with octreotide does not increase cholesterol saturation index, but may induce the occurrence of cholesterol crystals. The data are consistent with the view that gallstones induced by octreotide are cholesterol stones and suggest that the drug may impair gallbladder motility and/or decrease cholesterol nucleation time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02087655
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    Paper (German National Licenses)
    Fulltext
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