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  • 1
    Electronic Resource
    Electronic Resource
    GOLGI ARCHITECTURE AND INHERITANCE (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 18 (2002), S. 379-420 
    Details
    ISSN: 1081-0706
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Golgi inheritance proceeds via sequential biogenesis and partitioning phases. Although little is known about Golgi growth and replication (biogenesis), ultrastructural and fluorescence analyses have provided a detailed, though still controversial, perspective of Golgi partitioning during mitosis in mammalian cells. Partitioning requires the fragmentation of the juxtanuclear ribbon of interconnected Golgi stacks into a multitude of tubulovesicular clusters. This process is choreographed by a cohort of mitotic kinases and an inhibition of heterotypic and homotypic Golgi membrane-fusion events. Our model posits that accurate partitioning occurs early in mitosis by the equilibration of Golgi components on either side of the metaphase plate. Disseminated Golgi components then coalesce to regenerate Golgi stacks during telophase. Semi-intact cell and cell-free assays have accurately recreated these processes and allowed their molecular dissection. This review attempts to integrate recent findings to depict a more coherent, synthetic molecular picture of mitotic Golgi fragmentation and reassembly. Of particular importance is the emerging concept of a highly regulated and dynamic Golgi structural matrix or template that interfaces with cargo receptors, Golgi enzymes, Rab-GTPases, and SNAREs to tightly couple biosynthetic transport to Golgi architecture. This structural framework may be instructive for Golgi biogenesis and may encode sufficient information to ensure accurate Golgi inheritance, thereby helping to resolve some of the current discrepancies between different workers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.cellbio.18.030602.133733
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  • 2
    Electronic Resource
    Electronic Resource
    Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus (1984)
    [s.l.] : Nature Publishing Group
    Nature 308 (1984), S. 751-752 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The coronaviruses are a diverse class of enveloped RNA viruses of considerable medical and agricultural significance; they also provide a model for the study of persistent viral infections (see ref. 10 for review). In contrast to many enveloped viruses, the coronavirus mouse hepatitis virus (MHV) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/308751a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Stop-go proteins (1982)
    [s.l.] : Nature Publishing Group
    Nature 297 (1982), S. 624-625 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SOME ten years ago the discovery of the signal sequence1-2 showed how, in principle, the cell could 'tag' proteins destined for secretion. When a secretory protein is synthesized the first part of the growing polypeptide chain to emerge from the ribosomal complex is a 'signal' or 'leader' sequence ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/297624a0
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  • 4
    Electronic Resource
    Electronic Resource
    Protein transfer across microsomal membranes reassembled from separated membrane components (1978)
    [s.l.] : Nature Publishing Group
    Nature 273 (1978), S. 569-571 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Messenger RNA coding for light-chain immunoglobulin (Ig) was translated in a wheat germ cell-free system in the presence of RNase-treated rough microsomes (RMR) from canine pancreas5. The authentic Ig light chain (Li) was synthesised, together with a small amount of the light-chain precursor (p-Li) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/273569a0
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  • 5
    Electronic Resource
    Electronic Resource
    Golgi biogenesis in Toxoplasma gondii (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 418 (2002), S. 548-552 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two models have been put forward to explain the growth of new Golgi during the cell cycle. The first suggests that a new Golgi grows out of the endoplasmic reticulum by de novo synthesis. The second suggests that a pre-existing Golgi is needed for the growth of a new one, that is, the Golgi is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature00946
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  • 6
    Electronic Resource
    Electronic Resource
    p47 is a cofactor for p97-mediated membrane fusion (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 388 (1997), S. 75-78 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] At least two distinct ATPases, NSF and p97, are known to be involved in the heterotypic fusion of transport vesicles with their target membranes and the homotypic fusion of membrane compartments. The NSF-mediated fusion pathway is the best characterized, many of the components having been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/388075a0
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  • 7
    Electronic Resource
    Electronic Resource
    Matrix proteins can generate the higher order architecture of the Golgi apparatus (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 407 (2000), S. 1022-1026 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Golgi apparatus in animal cells comprises a reticulum of linked stacks in the pericentriolar and often in the juxtanuclear regions of the cell. The unique architecture of this organelle is thought to depend on the cytoskeleton and cytoplasmic matrix proteins—the best ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35039538
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  • 8
    Electronic Resource
    Electronic Resource
    Mitosis and membranes (1989)
    [s.l.] : Nature Publishing Group
    Nature 342 (1989), S. 857-858 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WHEN cells divide, the chromosomes segregate and all other cellular components are partitioned between the daughter cells1. For most membrane compartments in animal cells the mechanism involves wholesale break-up; the cell, in effect, homogenizes the membranes yet does so in a manner which permits ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/342857a0
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  • 9
    Electronic Resource
    Electronic Resource
    Bridging the gap (1993)
    [s.l.] : Nature Publishing Group
    Nature 362 (1993), S. 297-298 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A CLEAR view of the operation of the membrane fusion machinery inside cells emerges with the publication of two remarkable papers on pages 318 and 353 of this issue1'2, both from James Rothman and colleagues. They point to fundamental similarities in the way all membrane vesicles dock with and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/362297a0
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  • 10
    Electronic Resource
    Electronic Resource
    Trawling for receptors (1990)
    [s.l.] : Nature Publishing Group
    Nature 346 (1990), S. 318-319 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ENDOCYTOSIS is the process whereby substances on cell surfaces are enclosed in membrane-bound vesicles and taken into the cell. These substances then pass through the cell in what is usually thought of as an orderly itinerary of discrete stages (Fig. 1). But video images of living cells show that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/346318b0
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