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  • 1
    Electronic Resource
    Electronic Resource
    Basic Drives (1973)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Psychology 24 (1973), S. 53-80 
    Details
    ISSN: 0066-4308
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ps.24.020173.000413
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Corticotrophin-releasing factor produces a long-lasting enhancement of synaptic efficacy in the hippocampus (1998)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 10 (1998), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have previously demonstrated that intra-hippocampal injection of corticotrophin-releasing factor improved memory retention of an inhibitory avoidance learning in rats; while the electrophysiological effects corticotrophin-releasing factor produces on hippocampal neurons are largely uncharacterized. In the present study, we found that corticotrophin-releasing factor injected into the dentate gyrus of hippocampus produced a dose-dependent and long-lasting enhancement in synaptic efficacy of these neurons, as measured by an increase in the amplitude and slope of population excitatory postsynaptic potentials, as well as the amplitude of population spike. The onset of corticotrophin-releasing factor-induced potentiation was slow. It was observed approximately 40–60 min after corticotrophin-releasing factor administration and lasted for more than 5 h. This effect of corticotrophin-releasing factor was blocked by pretreatment with the cyclase-adenosine-3,5-monophosphate (cAMP) inhibitor Rp-adenosine-3,5-cyclic monophosphothiolate triethylamine (Rp-cAMPS) and partially blocked by the N-methyl-D-aspartate receptor antagonist MK-801. Further, pretreatment with corticotrophin-releasing factor receptor antagonist dose-dependently diminished tetanization-induced long-term potentiation, and corticotrophin-releasing factor and tetanic stimuli had an additive effect on hippocampal neuron excitation. Moreover, direct injection of corticotrophin-releasing factor increased cAMP level in the dentate gyrus. These results together suggest that corticotrophin-releasing factor-induced potentiation simulates the late phase of tetanization-induced long-term potentiation and cAMP seems to be the messenger mediating this effect. Moreover, corticotrophin-releasing factor-induced potentiation and long-term potentiation may share some similar mechanisms, and corticotrophin-releasing factor is probably involved in the neural circuits underlying long-term potentiation. Thus, corticotrophin-releasing factor may play an important role in modulating synaptic plasticity in the hippocampus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1998.00352.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Glucose and Osmosensitive Neurones of the Rat Hypothalamus (1969)
    [s.l.] : Nature Publishing Group
    Nature 222 (1969), S. 282-284 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Five-barrelled arrays of drawn glass capillary electrodes, measuring approximately 1 micron outside diameter at the tip, were used. One capillary, filled with 5 M NaCl, was used as the recording electrode for extracellular unit discharges and the others in the array were filled with various ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/222282a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of Intracarotid Injection of Hypertonic Saline on Spinal Reflex Excitability (1963)
    [s.l.] : Nature Publishing Group
    Nature 197 (1963), S. 390-391 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Changes in the amplitude of the monosynaptic spike in the cut fifth lumbar ventral root reflex discharge in response to appropriate low threshold, fast conducting afferent stimulation in cut muscle nerves of the hind leg served as a measure of this effect as a function of time following ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/197390a0
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    Paper (German National Licenses)
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