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  • 1
    Electronic Resource
    Electronic Resource
    Tilidine does not affect human sphincter of Oddi motility—a randomized, controlled study (1997)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the effects of intravenous pentazocine and tilidine on sphincter of Oddi motility.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Twenty patients with suspected sphincter of Oddi dysfunction were enrolled in a prospective, double-blind study. Sphincter of Oddi motility was assessed by means of endoscopic manometry after injection of 0.9% saline, as well as after randomized dosing with either 30 mg pentazocine i.v. (n = 10) or 50 mg tilidine i.v. (n = 10).〈section xml:id="abs1-3"〉〈title type="main"〉Results:Pentazocine significantly increased the sphincter of Oddi baseline pressure from 32 ± 21 mmHg (saline) to 41 ± 19 mmHg (P = 0.002), whereas tilidine did not alter the sphincter baseline pressure (34 ± 15 mmHg saline vs. 36 ± 16 mmHg tilidine, P = 0.16). Furthermore, pentazocine increased the phasic sphincter contraction amplitude (108 ± 16 mmHg saline vs. 121 ± 18 mmHg pentazocine, P = 0.004), but tilidine was without any effect (125 ± 24 mmHg saline vs. 125 ± 21 mmHg tilidine, P = 0.93). The phasic sphincter of Oddi contraction frequency and duration were not influenced either by pentazocine or by tilidine.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:In contrast to 30 mg of pentazocine, 50 mg of tilidine does not affect sphincter of Oddi motility. Therefore, tilidine can be used during endoscopic manometry and for analgesia in pancreatobiliary disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00221.x
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  • 2
    Electronic Resource
    Electronic Resource
    Endoscopic injection of botulinum toxin in patients with recurrent acute pancreatitis due to pancreatic sphincter of Oddi dysfunction (2000)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To evaluate the technical feasibility, safety, and short-term efficacy of botulinum toxin injection for pancreatic sphincter of Oddi dysfunction and to analyse whether the symptomatic response to botulinum toxin might be a predictor of outcome for endoscopic sphincterotomy.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Fifteen consecutive patients (nine female, aged 38 ± 12 years) with frequent attacks (median four) of acute pancreatitis within 6 months, and manometrically proven pancreatic sphincter of Oddi dysfunction underwent endoscopic injection of 100 units of botulinum toxin into the major papilla. All patients underwent prospective follow-up thereafter and in cases of recurrent pancreatitis manometry this was repeated and pancreatic sphincterotomy was performed.〈section xml:id="abs1-3"〉〈title type="main"〉Results:No side-effects occurred after botulinum toxin injection in any patient. Within 3 months after botulinum toxin treatment, 12 out of 15 patients remained asymptomatic (80% primary response). Only one out of three patients without symptomatic benefit showed continued elevated pancreatic sphincter pressure at manometry and only this patient benefited from pancreatic sphincterotomy later on. Eleven of the 12 patients initially responding to botulinum toxin injection developed a symptomatic relapse 6 ± 2 months after botulinum toxin treatment. These patients then achieved long-term clinical remission from pancreatic or combined (biliary and pancreatic, n=5) sphincterotomy (median follow-up, 15 months).〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:Endoscopic botulinum toxin injection into the papilla of Vater is a safe procedure for treatment of pancreatic sphincter of Oddi dysfunction that may provide short-term relief in about 80% of the patients. Those patients who respond to botulinum toxin may subsequently gain definitive cure from sphincterotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.00814.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of erythromycin on human biliary motility. (1996)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: BACKGROUND: To investigate the effects of intravenous erythromycin on human gall-bladder and sphincter of Oddi motor function. METHODS: Twelve consecutive patients with suspected sphincter of Oddi dysfunction were studied. Gall-bladder function was assessed by ultrasonography, and sphincter of Oddi motility was evaluated by means of endoscopic manometry. RESULTS: All patients were found to have normal gall-bladder function. The percentage of maximal gall-bladder emptying following a standardized, liquid test meal was significantly increased by erythromycin, whereas the postprandial residual gall- bladder volume was significantly decreased after erythromycin (P 〈 0.01). Endoscopic manometry revealed the presence of sphincter of Oddi dysfunction in two of the 12 patients. Erythromycin significantly decreased the basal sphincter of Oddi pressure and slowed the sphincter of Oddi phasic contraction frequency in all patients (P 〈 0.01). However, the mean duration of the sphincter phasic contractions (P 〈 0.05) and their amplitude (P = 0.05) were increased by the compound. CONCLUSIONS: Erythromycin stimulates gall-bladder motility but induces varying effects on human sphincter of Oddi motility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0953-0673.1996.00421.x
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of cisapride on antroduodenal motor function in healthy subjects and diabetics with autonomic neuropathy (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 5 (1991), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Antroduodenal manometry was used to assess motility in 10 healthy volunteers and 15 diabetics with cardiac autonomic neuropathy whilst they received 20 mg cisapride orally or an apparently identical placebo. Interdigestive motility was recorded after an overnight fast and for 2 hours following a 500 kcal liquid meal. Active treatment did not influence the number or duration of interdigestive motility cycles in either group although antroduodenal co-ordination in both the fasting and the fed state was enhanced by cisapride (P 〈 0.05). In diabetics the postprandial antral motility index was increased by cisapride, whereas in healthy subjects antral and duodenal motility indices were increased both fasting and in the fed state (P 〈 0.05).These results suggest that impaired antroduodenal co-ordination is of importance in delaying gastric emptying by diabetic subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1991.tb00528.x
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  • 5
    Electronic Resource
    Electronic Resource
    Einfluß von Cisaprid auf die Oesophagusmotilität bei Gesunden und Patienten mit progressiver systemischer Sklerodermie (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 602-607 
    Details
    ISSN: 1432-1440
    Keywords: Esophageal motility ; Cisapride ; Progressive systemic sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prokinetic agents might be useful in patients with progressive systemic sclerosis (PSS) who have disturbed function of the lower esophageal sphincter and impaired acid-clearance of the tubular esophagus. We therefore compared, by means of esophageal manometry, the effect of 20 mg cisapride orally vs. placebo in 12 patients with progressive systemic sclerosis and proven esophageal dysfunction as well as in 10 healthy volunteers in a double-blind, prospective trial. An increase of the lower esophageal resting pressure from 18.1±2.4 mm Hg to 23.9±8.1 mm Hg* after cisapride administration was observed in healthy volunteers, and from 10.9±3.2 mm Hg to 13.6+4.0 mm Hg* in the PSS patients. The amplitudes of peristaltic waves in the distal part of the esophagus were increased by cisapride from 83.8±10.6 mm Hg to 95.6±15.5mm Hg* in volunteers and from 28.9+12.8 mm Hg to 36.8±16.2 mm Hg in patients (*:P〈0.05). These results indicate that cisapride has a therapeutic rationale in the treatment of esophageal dysfunction in PSS; further clinical investigations are justified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01660958
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  • 6
    Electronic Resource
    Electronic Resource
    Shock wave treatment of salivary duct stones substantial progress with a minilithotripter (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 604-608 
    Details
    ISSN: 1432-1440
    Keywords: Lithotripsy ; Sialolithiasis ; Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Extracorporeal shock wave lithotripsy has recently been introduced as the first non-operative treatment alternative for patients with sialolithiasis. Using conventional multipurpose lithotripters, however, successful treatment was achieved in only 36%–53% of patients. Therefore we developed an miniaturized lithotripter meeting the special requirements for extracorporeal shock wave treatment in the head and neck region. During a 1-year prospective trial clinical efficacy and safety were compared in 40 patients treated with a conventional electromagnetic lithotripter (group A) to 33 patients treated with the newly developed, miniaturized device (group B). The groups did not differ statistically regarding stone size or number or the proportion of stones located in the submandibular or parotid gland. Successful stone targeting, a prerequisite for shock wave treatment, was achieved by means of in-line ultrasonography in 30 of the 40 patients in group A and in 29 of 33 patients of group B. The number of shock wave impulses administered per session and the maximum shock wave intensities did not differ in the two groups. Significantly more frequent treatments with a longer mean duration of each session were required in group A (2.4 ± 1.0 treatments, 47 ± 11 min) than in group B (1.9 ± 0.7 treatments, 28 ± 9 min; P 〈 0.05). After a 3 month follow-up significantly more patients were free of stones in group B (22/33) than in group A (16/40; P 〈 0.05). Correspondingly, the number of patients free of complaints was significantly higher in group B (27/33) than in group A (22/40; P 〈 0.05). Side effects did not differ between the two types of lithotripters, and they were moderate in intensity, completely reversible, and therefore without influence on the patient's outcome. It is concluded that the new miniaturized lithotripter provides a substantial progress for the feasibility and efficacy of shock wave treatment in sialolithiasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227453
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