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  • 1
    Electronic Resource
    Electronic Resource
    The postnatal development of the insertions of the medial collateral ligament in the rat knee (1996)
    Springer
    Anatomy and embryology 193 (1996), S. 53-59 
    Details
    ISSN: 1432-0568
    Keywords: Ligament ; Bone ; Enthesis ; Remodelling ; Morphogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bone soft tissue remodelling at the femoral and tibial insertions of the medial collateral ligament (MCL) of the rat knee was monitored at regular intervals from birth to 120 days of age in 40 Sprague Dawley rats. At birth the femoral insertion originated from the perichondrium of the epiphysis. By day 8 the perichondrium within the insertion had turned into fibrocartilage. Secondary ossification of the femoral epiphysis had progressed in the region near to the insertion site by day 15. The epiphyseal cartilage was entirely replaced by bone by day 40 except for the fibrocartilage within the insertion. After that stage, no qualitative change in zonal insertion characteristics was observed, but only increase in size and decrease in cellularity. At birth, the tibial ligament inserted onto the thin cortical bone of the metaphysis via periosteum. At day 8, osteoclasts started to resorb the thin cortical bone at the ligament insertion, thus forming a metaphyseal depression between days 10 and 20. From days 20 to 120, the insertion remained qualitatively unchanged, showing three zones, the ligament, periosteum, and metaphyseal trabecular bone. The deep periosteal layer showed osteoclastic activity in the proximal part and osteoblastic activity in the distal part. The migration mechanism of the ligament insertion during growth seems to be caused by this growth-related osteoclastic resorption of the proximal metaphyseal bone and by simultaneous osteogenic activity, which successively cements the distal part of the ligament to bone. The persistence of the periosteal layer and the metaphyseal depression for up to 120 days may be regarded as a sign of continuing growth in this animal model. This is the first investigation showing that the formation of the metaphyseal depression is a purely postnatal event, and suggests that this process might be initiated by the change in mode of growth and joint biomechanics after birth, enabling ligament development and migration in a growing and increasingly loaded weight-bearing joint. The mainly resorptive process, which takes place during development of the tibial MCL insertion, may account for the tensile failure of this ligament that commonly occurs at this site during growth. The pronounced morphological differences between the chondral femoral and the periosteal tibial attachment of the adult MCL are apparently caused by the different postnatal developmental processes at epiphyses and metaphyses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186833
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Maturation-dependent repair of untreated osteochondral defects in the rabbit knee joint (1997)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 34 (1997), S. 63-72 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Repair of untreated full-thickness cartilage defects in the medial femoral knee condyle was studied in 17 young, 21 adolescent, and 19 adult rabbits. At 6 weeks, the defect was completely filled by tissue regeneration in all young and adolescent animals, but in only few of the adults (p 〈 0.05). The morphology of all repairs improved from fibrous tissue to hyaline-like cartilage over time (p 〈 0.05), but at 3 and 6 weeks, the repair tissue in young and adolescent rabbits was more cartilage-like than in the adults (p 〈 0.05). In addition, bonding of the repair tissue to the adjacent cartilage was better in the young and adolescent than in the adult animals (p 〈 0.05). At 12 weeks, subchondral bone had formed in some young and adolescent repairs, but in no case in the adults. None of the repairs showed normal cartilage appearance, but formation of hyaline-like cartilage was common at 12 weeks. Irrespective of age or observation time, the repair site showed decreased stiffness and larger strain values compared to adjacent or control cartilage (p 〈 0.001) with no tendency for improvement over time. Younger animals showed a faster filling of the defect and an earlier specialization of the repair tissue than adult animals, but the mechanical quality of the regenerated tissue remained inferior to normal. © 1997 John Wiley & Sons, Inc.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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