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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 79 (1957), S. 1303-1305 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 25 (2000), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent studies suggest that histamine H2-receptor antagonists may be useful in the treatment of urticaria. This study was conducted to determine whether famotidine, a H2 antagonist, is effective in the treatment of acute urticaria and compare its effect with that of the H1 antagonist diphenhydramine. In this prospective, double-blind, controlled trial, 25 patients with urticaria of less than 72 h duration were randomized to receive a single dose of either famotidine 20 mg i.m. or diphenhydramine 50 mg i.m. Prior to treatment and 30 min after treatment, patients rated pruritus and sedation using visual analogue scales, while physicians evaluated intensity of urticaria and percentage of body surface area involved by urticaria. Famotidine was found to reduce pruritus associated with acute urticaria, intensity of urticaria, and body surface area affected by urticaria without causing sedation. Famotidine was comparable to diphenhydramine in efficacy; however, there was a (nonsignificant) trend for diphenhydramine to be more effective than famotidine in the treatment of pruritus, and for famotidine to be more effective in the reduction of surface area of involvement. It is concluded that famotidine merits further investigation as a potential medication for treatment of urticaria.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1439-6327
    Keywords: Tissue insulation ; Water immersion ; Thermoregulation ; Body morphology ; Surface area-tomass-ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven male volunteers were divided into two groups based on body morphology and mass. The large body mass (LM) group (n = 4) was 21.2 kg heavier and 0.32 m2 · kg −1 smaller in surface area-to-mass ratio (P〈 0.05) than the small body mass (SM) group (n = 3) Both groups were similar in total body fat and regional skinfold thicknesses. All subjects were immersed to the first thoracic vertebrae for 120 min in stirred water at 18°C. Overall, tissue insulation was similar (P〉0.05) between the SM and LM groups across time. Perceptual ratings of thermal sensation increased (P〈0.05) across time. Therefore, as cold water immersion progressed, tissue insulation was similar and thermal sensation increased (P〈0.05) in males matched for subcutaneous fat and total fat but differing in body mass and morphology.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 68 (1994), S. 291-297 
    ISSN: 1439-6327
    Keywords: Energy substrates ; Metabolism ; Temperature regulation ; Thermogenesis ; Shivering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The increased metabolic heat production in humans exposed to cold stress results from an increased oxidation of both carbohydrate and fat to provide energy to sustain temperature homeostasis. Research suggests that dietary manipulations may enhance metabolic heat production, thereby delaying hypothermia. Therefore, the present investigation examined the thermogenic effect of a sequential timed feeding regime of either a carbohydrate (CHO) or a placebo beverage (PL) before and again midway through 120 min of exposure to 8, 12 and 27° C in well-nourished men. The following were examined: tissue insulation (I), rectal temperature (T re), mean skin temperature $$\bar T_{{\text{sk}}}$$ , metabolism (M), time-weighted heat production and respiratory exchange ratio (R).T re, ΔT re, $$\bar T_{{\text{sk}}}$$ M, ΔM,I and time-weighted heat production revealed no significant differences between treatment (PL vs CHO) at any temperature (8, 12 and 27° C). However,T re decreased (P 〈 0.05) as time increased at 8, 12 and 27° C while M increased (P 〈 0.05) andI decreased (P 〈 0.05) at 8 and 12° C. At 8 and 27° C,R differed (P 〈 0.05) between the PL and CHO treatments. In addition, at 8 and 12° C,R increased (P 〈 0.05) across time reflecting the feeding. From these data it appears that while substrate utilization differed between dietary treatment (8 and 27° C) and across time, this feeding regime did not differentially affectT,T re, $$\bar T_{{\text{sk}}}$$ andI during 120 min of exposure to 8, 12 and 27° C.
    Type of Medium: Electronic Resource
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