ISSN:
1540-8191
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
A canine femoral artery model was used for evaluation of a dialdehyde starch preserved bovine internal mammary artery (BIMA) (3 and 4 mm internal diameter) in comparison to a polytetrafluoroethylene (PTFE) graft. The study comprised three groups for a 2-hour (n = 7, 3 mm), 3-month (n = 10, 4 mm), and 6-month (n = 10, 4 mim) follow-up. The thrombogenicity of the grafts was measured after 2 hours and 3 months using chromium 51 labeled autologous platelets. In addition, compliance studies were done. To control the wall stability of the xenografts, the collagen content before implantation and after explantation was examined together with the diameter of the grafts. Healing characteristics were studied using appropriate histologic methods. The acute platelet adhesion rate (2 hours) of the BIMA graft was 181 ± 69 × 104 platelets/mm2 as compared to 57 ± 43 × 104 for PTFE (p 〈 0.05, t-test). However, after 3 months the thrombogenicity of the biograft had decreased whereas the platelet count at the PTFE graft had increased (BIMA: 79 ± 48 × 104; PTFE: 179 ± 102 × 104, p 〈 0.05). At implantation, the compliance of the BIMA graft was 0.028%± 0.009% per mmHg as compared to 0.06%± 0.0025% of the femoral artery. The PTFE graft was uncompliant (0.008 ± 0.005). After 6 months, the compliance of the femoral artery had decreased to 0.039%± 0.013% per mmHg, which was now well matched to the nearly unchanged compliance of the biograft (0.0027 ± 0.005). The external diameters and the collagen contents of the xenografts remained unchanged. In contrast to PTFE, the xenografts developed no diameter-reducing neointima. After 6 months, six out of ten BIMA grafts and only two out often PTFE grafts remained patent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1540-8191.1992.tb00792.x
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