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  • 1
    Electronic Resource
    Electronic Resource
    Radiographic appearance of an ossifying fibromyxoid tumor of soft parts (1997)
    Springer
    Skeletal radiology 26 (1997), S. 615-618 
    Details
    ISSN: 1432-2161
    Keywords: Key words Ossifying fibromyxoid tumor of soft parts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  This case report describes an ossifying tumor in the left musculus erector spinae in a 32-year-old man. Radiologically it showed irregular lamellar bone formation in the periphery, demonstrating as juxtacortical and macroscopically sarcoma-like features. Histologic it was diagnosed as an ossifying fibromyxoid tumor of soft parts (OFTSP). The CT features of this tumor have never previously been reported. This is the first time pulmonary metastases, malignant pleural effusion, and death of the patient directly related with an OFTSP have been described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050296
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  • 2
    Electronic Resource
    Electronic Resource
    A new, simple method for intraoperative fast diagnosis (1979)
    Springer
    Virchows Archiv 382 (1979), S. 89-94 
    Details
    ISSN: 1432-2307
    Keywords: Imprint-cytology ; Testsimplets® ; Intraoperative fast diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The suitability of stain-coated, ready-to-use slides (Testsimplets®) for routine staining of intraoperative imprint-cytology preparations is discussed. The microscopic preparations are easily and quickly prepared, may be evaluated immediately and, with a slight loss of quality, may be kept for up to a week after application of paraffin to the cover glass. This method produces interpretable slides from cell-rich benign and malignant tumors. It is by no means a complete substitute for the usual fast-section techniques, but may be used in order to save time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01102743
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Intermediate filaments and desmosomal plaque proteins in testicular seminomas and non-seminomatous germ cell tumours as revealed by immunohistochemistry (1987)
    Springer
    Virchows Archiv 410 (1987), S. 295-307 
    Details
    ISSN: 1432-2307
    Keywords: Intermediate filaments ; Desmosomes ; Testicular tumours Germ cell tumours ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seminomas and non-seminomatous testicular germ cell tumours were studied for the presence of cytokeratin and vimentin filaments and desmosomes using immunohistochemical methods. In the majority of the classical seminomas and in seminomatous areas of mixed tumours most tumour cells appeared to lack cytokeratin filaments. Some seminomas contained a focally variable proportion of cells exhibiting cytokeratin-positive structures while other cases contained only few seminoma cells with a well developed fibrillar cytokeratin network. Gel electrophoresis of cytoskeletal proteins from microdissected regions revealed cytokeratin polypeptides nos. 8 and 18 typical of simple epithelia. In one seminoma, however, all, or almost all, tumour cells contained cytokeratin filaments. This finding is in line with the assumption of transitional forms between seminoma and embryonal carcinoma. Despite the lack - or variable expression - of cytokeratin filaments most seminoma cells contained desmosomes, although often few in number and irregularly distributed at the circumference of the cells. Loosely arranged and often very sparse vimentin fibrils were found in many, but not all seminoma cells. Double label immunofluorescence microscopy suggested that the majority of desmosomes was associated with intermediate filaments of the vimentin type. In contrast, in carcinoma cells of malignant teratomas, in well differentiated epithelial cells of intermediate-type malignant teratomas and in trophoblastic cells present in trophoblastic-type malignant teratomas cytokeratin filament bundles as well as desmosomes were decorated. The arrangement and density of the cytokeratin filament skeleton and of desmosomes varied with degree of maturation of the tissue. The most regular distribution and intensive staining of cytokeratin filaments and desmoplakin was found in “mature” tissues. Vimentin was demonstrated in mesenchymal areas and stroma cells. The results show that seminomas are distinguished from most other germ cell and non-germ cell tumours by the presence of true desmosomes together with scanty vimentin filaments in most tumour cells. In addition, they indicate that seminoma cells can be heterogenous in their cytoskeletal complement and may include cells with cytokeratin expression, indicative of a multi-potential character of the initially transformed cell(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711286
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution of TPA and cytokeratins in gastrointestinal carcinomas as revealed by immunohistochemistry (1986)
    Springer
    Virchows Archiv 409 (1986), S. 641-655 
    Details
    ISSN: 1432-2307
    Keywords: Gastrointestinal carcinomas ; Tissue polypeptide antigen (TPA) ; Cytokeratins ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence and distribution of tissue polypeptide antigen (TPA) were assessed in gastrointestinal carcinomas of different origin, morphology and degree of differentiation. Immunocytochemistry was employed, using the PAP technique on formalin-fixed, paraffin-embedded material and compared with the results obtained with antibodies to cytokeratins. Like cytokeratins, TPA was a reliable marker of epithelial differentiation and showed tissue distribution patterns similar to cytokeratins, as revealed by antibodies with broad-range cytokeratin immunoreactivity. In most carcinomas, TPA-specific immunostaining was less intense than in non-neoplastic tissue. No direct relationship between intensity of TPA staining and morphological degree of differentiation and proliferation was found. TPA staining was most pronounced at the periphery of the cells. In stratified epithelium, i.e. oesophageal mucosa, basally located cells exceeded superficial cells in TPA immunoreactivity in contrast to the cytokeratin antibodies which decorated the more superficially placed cell layers. TPA and cytokeratin staining patterns were similar in neoplastic and non-neoplastic gastric, intestinal mucosa, as well as in biliary tract epithelium. Antral and cardial mucoid glands of the stomach as well as gastric carcinomas of the pylorocardial type remained unstained with both types of antibodies. Similar staining with TPA and cytokeratin antibodies was also observed in pancreatic and liver tissue. In this study, hepatocytes were, although weakly, stained by TPA antibodies and an identical staining was found with benign and malignant hepatocellular neoplasms. Ductal and ductular TPA-staining was most conspicuous and so was the immunoreactivity of cholangiocellular carcinomas. A comparison between TPA and cytokeratins was also made by immunoblotting which revealed immunoreactivity of antibodies to TPA with cytokeratin polypeptides of different species (man, mouse) and organs (epidermis, liver), particularly with the cytokeratin component 8 of human liver and the related component A of mouse liver. The significance of this finding is uncertain until the pertinent epitopes have been revealed by monoclonal mapping of the components which exhibit similar molecular weights by SDS polyacrylamide gel electrophoresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713430
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of superoxide dismutase on staphylococcal arthritis—A histological and biochemical investigation using an experimental animal model (1990)
    Springer
    Inflammation research 29 (1990), S. 259-265 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of superoxide dismutase (SOD) on staphylococcal arthritis has not been successfully evaluated to date. A suitable animal model has been developed to investigate a possible correlation. Using 16 rabbits divided into four groups, we injected the knee joints of two groups with Staphylococcus aureus and the other two with NaCl. One group in each of the two treatment groups was also injected with SOD. Blood samples and samples of joint fluid were taken at 12 hour intervals. Lipids were measured in plasma and joint fluid. The joints were examined macroscopically and microscopically using a scoring system to quantitate the deterioration of joint structures. Lipid peroxide concentrations measured in plasma differed in each of the groups, with higher values found in animals with septic arthritis compared with controls. The estimations made of lipid peroxide in joint fluid also displayed extreme variability, with the highest values found in animals with Staphylococcal arthritis treated with SOD. Histological examination also verified that the infected joints injected with SOD showed significantly more inflammation, a higher amount of bacteria in the joint cavity, and more distinct joint damage than joints injected only with bacteria. The mechanisms responsible for this SOD effect remain to be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966456
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