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  • 1
    Electronic Resource
    Electronic Resource
    Social Structure of World Regions: Mainland China (1977)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Sociology 3 (1977), S. 179-207 
    Details
    ISSN: 0360-0572
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Sociology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.so.03.080177.001143
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Rationale Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma.Objectives We investigated the association of lung function with GSTM1, GSTP1 and GSTT1 genotypes in Caucasian families with asthma.Methods Four hundred and eighteen children and 316 parents from 224 Caucasian families were recruited via a child with asthma, the proband. Associations between lung function and GST genotype were determined using multilevel models.Results There were no observed associations between lung function and GST genotype in parents. However, in the children, the GSTP1 val105/val105 and GSTM1 null genotypes were associated with significantly higher forced expiratory volume in 1 s (FEV1) and FVC values as percentage of predicted. This effect was not statistically significant in the probands but was marked in their siblings in whom GSTP1 val105/val105 was associated with 9.4% higher FEV1 and 10.7% higher FVC (P=0.005 and 0.001, respectively). The GSTM1 null genotype was associated with a 6.7% higher FEV1 and 4.1% higher FVC (P=0.003 and 0.063, respectively). These effects remained significant after correcting for the confounders of individual atopic status, tobacco smoke exposure and familial aggregation of lung function values.Conclusions GSTM1 and GSTP1 genotypes are important determinants of lung function in childhood. The smaller differences seen in probands are predicted by a simple model in which more rapid decline in lung function is seen in these individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2005.02313.x
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  • 3
    Electronic Resource
    Electronic Resource
    Toll-like receptors: their role in allergy and non-allergic inflammatory disease (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The human TLRs comprise an important and interesting group of receptors that regulate pathogen-related responses, and play as yet uncharacterized roles in the amplication of sterile inflammation. Signalling through these receptors, which are powerfully coupled in gene transcription processes, has powerful immunostimulatory and immunomodulatory effects. Exploitation of TLR signalling will probably lead to novel effective therapies for allergic disease, in the first instance through more efficient mechanisms of immunotherapy. The likelihood of adverse consequences of such treatments, though possible, may be minimized by use of conjugated vaccines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2745.2002.01451.x
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    Paper (German National Licenses)
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