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  • 1
    Electronic Resource
    Electronic Resource
    The Presence of Immunoglobulins in the Gastric Juice of Patients Infected With Helicobacter pylori is Related to a Reduced Secretion of Acid (2002)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 7 (2002), S. 0 
    Details
    ISSN: 1523-5378
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. It has been reported that treatment with proton pump inhibitors (PPI) leads to partial elimination and suppression of Helicobacter pylori. In theory, since acid is known to denature immunoglobulins, this antibacterial activity of PPI may be due to a reduction in the acid output favouring humoral immunity.Materials and methods. We analysed prospectively fasting gastric juice in 54 consecutive patients attending upper endoscopy for pH and levels of IgG, IgA and IgM. In addition, two antral and two corpus biopsies were obtained and histologically examined for the presence of H. pylori.Results. 41/54 patients were infected with H. pylori. Immunoglobulines in the gastric juice of these patients were found in 25/41 (IgG), 27/41 (IgA), and 29/41 (IgM) patients. There was a highly significant difference in the gastric pH when H. pylori infected patients with measurable IgG, IgA, or IgM were compared with those in whom no immunoglobulines were found (median pH: 6 vs. 2 in each group; p 〈 .001)Conclusions. There is a close correlation between a high gastric pH and the presence of IgG, IgA, and IgM antibodies. Hence, it may be speculated that the efficacy of humoral immunity following H. pylori infection depends on a high pH such as resulting from PPI treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1523-5378.2002.00058.x
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of oligoclonal IgA in cerebrospinal fluid samples by an isoelectric focusing procedure (1994)
    Springer
    Journal of neurology 241 (1994), S. 315-319 
    Details
    ISSN: 1432-1459
    Keywords: Isoelectric focusing ; Cerebrospinal fluid ; Oligoclonal IgA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An isoelectric focusing procedure for the detection of oligoclonal IgA in cerebrospinal fluid (CSF) samples is presented. CSF IgA bands were found in 69% of patients with various inflammatory neurological diseases, in 22% of patients with other neurological diseases, but in none of the patients with non-neurological diseases. In patients with inflammatory neurological diseases we examined the relationship between an intrathecal synthesis of oligoclonal IgA and an intrathecal IgA synthesis as proved by a formula recently described by Reiber and Felgenhauer: 83% of patients with an intrathecal IgA synthesis according to the formula of Reiber and Felgenhauer also showed CSF IgA bands whereas 59% of patients without an intrathecal IgA synthesis displayed an intrathecal synthesis of oligoclonal IgA. Seventeen percent of patients with inflammatory neurological diseases were characterized by an intrathecal synthesis of oligoclonal IgA but did not show either an intrathecal IgA synthesis or an intrathecal synthesis of oligoclonal IgG, the detection of oligoclonal IgA therefore being the only evidence of an intrathecal humoral immune response in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00868439
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  • 3
    Electronic Resource
    Electronic Resource
    Verstärkung von Polysiloxanen mit Thermoplasten (1977)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 58 (1977), S. 243-257 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Radical polymerization of organic monomers in room-temperature curable polydimethylsiloxanes (PDMS) yields liquid dispersions of thermoplastic polymers in PDMS. Graft copolymers of organic polymers and PDMS generated in the polymerization stabilize these dispersions like nonionic surfactants and act as a link between organic polymer particles and PDMS-matrix after vulcanization. This linkage and the special, rod-like shape of the polymer particles cause reinforcing effects, leading to vulcanizates that show unusual toughness in comparison to ordinary silicone rubber.
    Notes: Bei der radikalischen Polymerisation von organischen Monomeren in kaltvulkanisierbaren Polydimethylsiloxanen (PDMS) entstehen flüssige Dispersionen von Thermoplasten in PDMS. Während der Polymerisation gebildete Pfropfcopolymerisate von organischen Polymeren auf PDMS stabilisieren diese Dispersionen ähnlich wie nichtionische Tenside und verankern bei der Vulkanisation die organischen Polymerpartikel in der Siloxanmatrix. Durch diese Verankerung und durch die besondere, stäbchenförmige Gestalt der Polymerpartikel kann ein Verstärkungseffekt erzielt werden, der zu Vulkanisaten mit einer gegenüber herkömmlichem Siliconkautschuk ungewöhnlichen Festigkeit führt.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1977.050580111
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  • 4
    Electronic Resource
    Electronic Resource
    Über Peptid-Synthesen I (1952)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 575 (1952), S. 217-231 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19525750207
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