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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Peptides 11 (1990), S. 501-506 
    ISSN: 0196-9781
    Keywords: ANF disappearance ; High salt intake ; Metabolic clearance rate ; Tissue uptake ; Volume of distribution
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 18 (1986), S. 53 
    ISSN: 0022-2828
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2013
    Keywords: Altitude ; Myocardium ; Regional blood flow ; Blood volume ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circulating blood volume, cardiac output and relative organ perfusion changes were studied, using the Sapirstein method of86Rb tissue uptake, in male 75-day-old rats exposed to intermittent high altitude hypoxia (gradually up to 7000 m, 4 h daily, 5 days a week; the total number of exposures was 24). Intermittent hypobaric exposure caused a significant rise of the erythrocyte volume, whereas the plasma volume remained unchanged. The relative perfusion of the left and particularly of the right ventricular myocardium, as well as of the spleen, liver, lung, small intestine and skeletal muscle, was significantly higher. The cardiac output determined in other experimental animals similarly treated was significantly higher after 24 exposures to the intermittent high altitude hypoxia. We suggest that these changes are triggered by tissue hypoxia and a greater blood flow demand.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 49 (1995), S. 95-102 
    ISSN: 1432-1041
    Keywords: Congestive heart failure ; ACE inhibitor ; spirapril ; bicycle ergometer exercise test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract A randomized, double-blind, placebo- and active-controlled multicentre study with spirapril, a new angiotensin-converting enzyme inhibitor (ACEI), has been conducted in patients with chronic congestive heart failure (CHF) of NYHA classes II–IV. After a placebo run-in period of 1–4 weeks, patients were randomly assigned to one of five treatment groups: placebo (n=48), spirapril 1.5 mg (n=48), spirapril 3 mg (n=53), spirapril 6 mg (n=51) or enalapril 5/10 mg (n=48). The primary objective was to assess changes in exercise tolerance, and the secondary objective was an assessment of cardiovascular signs and symptoms, quality of life, ejection fraction and chest X-ray findings. Exercise tolerance increased in all groups; however, no statistically significant differences were found between any of the groups. There was a statistically significant reduction of mortality in the pooled spirapril groups compared with placebo, and a trend for reduction of serious cardiovascular adverse events as well as duration of hospitalization. These effects and improvements in lung congestion appeared to be dose dependent. In patients with moderate to severe heart failure, the combination with first-generation calcium channel blockers had an unfavourable effect on exercise capacity and clinical parameters. Spirapril might be an effective alternative to enalapril in the treatment of patients with CHF. The role of the exercise tolerance test in establishing efficacy of ACEIs in CHF and the widespread use of nifedipine in CHF is questioned.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Lung 141 (1969), S. 109-117 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The authors compare two methods of overexertion of the cardiopulmonary system, namely by a unilateral occlusion of the pulmonary artery and by muscular exercise. The two methods were always used both in one and the same person in the framework of one investigation by catheterization. The tests were performed in a group of 9 persons. The reactions to the two tests not identical and differed in size, quality and localization of the pathological findings. The authors further mention three cases: A woman patient with a normal lung finding, a man patient with a predominantly unilateral lesion affecting the entire lung wing for whom a greater load was represented by the muscular exercise, and finally a woman patient with a bilateral affection of the lung parenchyma, where on the other hand the values measured were less favourable with the occlusion. The observations made indicate that occlusion is more serious for those patients in whom in case of a more extensive restriction of the pulmonary bed there is eliminated from perfusion the lung parenchyma in which an exange of blood gases still takes place. If the part of the lung eliminated by the occlusion is damaged and is no longer of considerable importance for the respiration, it is, on the other hand, muscular exercise as a rule that means a greater strain, particularly when most of the blood flows through other parts of the lungs anyway, even prior to the occlusion. In case of hypertension there rather takes place an increased rate of flow with a rising minute volume of the heart.
    Notes: Zusammenfassung Die Autoren vergleichen zwei Methoden der Belastung des kardiopulmonalen Systems: die einseitige Pulmonalisokklusion und die Muskelarbeit. Sie benützen beide Methoden bei einer und derselben Person im Rahmen einer Katheterisationsuntersuchung. Diese Prüfungen wurden bei einer Gruppe von 9 Personen durchgeführt. Die Reaktionen auf beide Untersuchungsmethoden waren ungleich, sie unterschieden sich nach der Größe, der Qualität und der Lokalisation der pathologischen Veränderungen. Die Autoren erläutern das an 3 Fällen, einer Kranken mit normalem Lungenbefund, einem Patienten mit überwiegend einseitiger Schädigung des ganzen linken Lungenflügels, für den die Muskelarbeit größere Belastung bedeutete, und schließlich einer Patientin mit beiderseitig geschädigtem Lungenparenchym, wo die größere Belastung bei der Okklusion entstand.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-7241
    Keywords: chronic hypoxia ; pulmonary hypertension ; right ventricular hypertrophy ; enalapril ; fibrosis ; collagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic hypoxia induces pulmonary hypertension and right ventricular hypertrophy. These changes are completely reversible, except for persistent myocardial fibrosis. The aim of the present study was to determine whether treatment with the angiotensin-converting enzyme (ACE) inhibitor enalapril can reduce the ventricular collagen content in animals recovering from chronic hypoxia. Adult male Wistar rats were exposed to intermittent high-altitude hypoxia simulated in a barochamber (7000 m, 8 hr/day, 5 days a week, 24 exposures), then transferred to normoxia and divided into two groups: (a) treated with enalapril (0.1 g/kg/day for 60 days) and (b) without treatment. The corresponding control groups were kept under normoxic conditions. Enalapril significantly decreased the heart rate, systemic arterial pressure, and absolute left and right ventricular weights in both hypoxic and control rats; on the other hand, the pulmonary blood pressure was unchanged. The content and concentration of collagen was reduced in both ventricles of enalapril-treated hypoxic and control animals by 10–26% compared with the corresponding untreated groups. These data suggest that the partial regression of cardiac fibrosis due to enalapril may be independent of the pressure load.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei erwachsenen männlichen Ratten wurden die Auswirkungen einer Beta-Rezeptoren-Blockade auf die pulmonale Hypertension und die rechtsventrikuläre Hypertrophie untersucht, die durch Hypoxie unter intermittierender Höhenexposition ausgelöst wurden (8 Stunden täglich; 5 Tage pro Woche; stufenweise Steigerung bis zu einer simulierten Höhe bis zu 7000 m). Trimepranol wurde eine Stunde vor der Höhenexposition als Einzeldosis (10 mg/kg) subkutan injiziert. Die Verabfolgung des Beta-Rezeptoren-Blockers verursachte signifikante Änderungen der Hämatokritwerte selbst bei Tieren, die unter normoxischen Bedingungen gehalten wurden. Ein initialer erheblicher Abfall war gefolgt von langsamer Rückkehr zu den Kontrollwerten. Verlängerung der Behandlung führte zu weiterer signifikanter Abnahme des Hämatokrits. Die Polyzythämie nach Höhenexposition war daher bei mit Trimepranol behandelten Tieren eindeutig weniger ausgeprägt als bei der nicht behandelten “hypoxischen” Gruppe. Verabfolgung von Trimepranol reduzierte bei den Ratten mit Höhenexposition eindeutig den rechtsventrikulären systolischen Druck und Mitteldruck, die Hypertrophie des rechten Ventrikels und die Dicke der Muskelwand der Pulmonalarterie. Man kann annehmen, daß der protektive Effect von Trimepranol a) auf Änderungen der pulmonalen Vaskularisation, b) auf eine Reduktion der Polyzythämie und c) auf ein geringeres Herz-Minuten-Volumen zu beziehen ist, letzteres induziert durch die negativ inotropen und chronotropen Effekte der Substanz.
    Notes: Summary Adult male rats were used to study the effect of a beta blocking agent on pulmonary hypertension and right ventricular hypertrophy induced by intermittent high altitude (IHA) hypoxia (8 hr daily, 5 days a week, stepwise up to the simulated altitude of 7000 m). Trimepranol was injected subcutaneously in a single dose of 10 mg/kg/b.w. one hour before each IHA exposure. Administration of the beta blocking drug caused significant changes of haematocrit values even in animals kept under normoxic conditions. The initial deep decrease was followed by a slow return to control values; prolongation of treatment led to a further significant decrease of the haematocrit curve. The polycythaemic response of IHA-exposed and Trimepranol-treated animals was, therefore, significantly less pronounced as compared with the hypoxic non-treated group. Administration of Trimepranol to IHA-exposed rats significantly decreased the values of right ventricular systolic and mean pressure, right ventricular hypertrophy as well as the degree of muscularization of pulmonary arteries. It may be assumed that the protective effect of Trimepranol is due to a) changes in pulmonary vascularization, b) reduction of polycythaemia, and c) lower cardiac output, induced by the negative inotropic and chronotropic effect of this drug.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Basic research in cardiology 28 (1958), S. 100-124 
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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