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  • 1
    Electronic Resource
    Electronic Resource
    Atherosclerotic complications after renal transplantation (2000)
    Springer
    Transplant international 13 (2000), S. S14 
    Details
    ISSN: 1432-2277
    Keywords: Key words Atherosclerosis ; Renal transplantation ; Hypertension ; Left ventricular hypertrophy ; Hyperlipidemia ; Statines ; Hyperhomocysteinemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Death with functioning graft, the most frequent cause being cardiac death, continues to be the most frequent cause of long-term graft loss. The risk of cardiovascular death in the transplanted patient is lower than in patients with other modalities of renal replacement therapy, but continues to be substantially higher than in the general population. Amongst the factors predicting patient and graft survival are hypertension, dyslipidemia, smoking and possibly hyperhomocysteinemia. It is concluded that lowering of blood pressure to levels far lower than levels accepted in the past, more widespread administration of statines, cessation of smoking and possibly administration of folate should reduce cardiovascular mortality and possibly also influence chronic allograft vasculopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050267
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    P-glycoprotein expression is not a useful predictor of acute or chronic kidney graft rejection (1999)
    Springer
    Transplant international 12 (1999), S. 10-17 
    Details
    ISSN: 1432-2277
    Keywords: Key words Renal transplantation ; P-glycoprotein expression rejection ; Rejection ; P-glycoprotein expression ; renal transplantation ; P-glycoprotein expression ; rejection ; renal transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Because of the role of P-glycoprotein (P-gp) in multidrug resistance (MDR), it has been suggested that P-gp might play a role in acute and chronic rejection after organ transplantation. The purpose of the present work was to investigate a possible relationship between graft outcome and P-gp expression on peripheral mononuclear cells of renal transplant recipients. We determined P-gp expression in 27 patients with long-term, stable graft function (ST) and in 15 patients with chronic deterioration of graft function (CR). In addition, 40 patients were studied prior to, and at intervals after, transplantation with 21 healthy individuals serving as controls. P-gp values were highest in healthy controls and in ST patients. We found no correlation between P-gp values and acute rejection. CR patients tended to have lower levels of P-gp expression. Our results contradict the opinion that an overexpression of P-gp induces acute or chronic rejection by inhibiting the efficacy of immunosuppressive treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050179
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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