ISSN:
0749-1581
Keywords:
1H and 13C NMR
;
Oxygenated lanostane derivatives
;
Spectral assignment
;
Lanthanide-induced shifts
;
Long-range HETCOR
;
Acetylation shifts
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
1H and 13C NMR assignments are presented for 30 oxygenated lanostane derivatives, including lanosterol, dihy-drolanosterol, 7-ketolanosterol, agnosterol, 24,25-epoxylanosterol, 8α,9α-epoxylanostan-3β-ol, three 15-oxygenated derivatives of lanost-7-en-3β-ol, lanostane-3β,7α-diol, lanostane-3β,9α-diol and their acetates. These assignments, which were largely determined by a combination of DEPT, one-boad and long-range 13C—1H chemical shift correlation and lanthanide-induced shift experiments, are not dependent on previously reported assignments, several of which were found to be incorrect. 1H and 13C acetylation shifts for lanostan-3β-ols were sufficiently invariant among the sterols studied that they were useful for assigning carbons in rings A and B. The acetylation shifts reported for lanostan-3β-ols were extended and partially revised.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260271103
Permalink