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  • 1
    Electronic Resource
    Electronic Resource
    The intraosseous ganglion A clinical-pathological report on 42 cases (1994)
    Springer
    Archives of orthopaedic and trauma surgery 114 (1994), S. 14-17 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study we report on the clinical, radiological and pathologic data of 42 intraosseous ganglia which had been verified histologically. Of the patients, 26 were male and 16 female. Their mean age was 41.8 years (range 20–71 years). Exclusively solitary ganglia were included in this study; mainly they were located within the lower extremity. In most cases (n = 12), the malleolus medialis was involved. In 40 patients, treatment consisted of curettage, in 39 cases in combination with autologous or homologous bone grafting. In 2 cases, a resection was performed. No local recurrence was observed. Etiology and pathogenesis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454729
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  • 2
    Electronic Resource
    Electronic Resource
    Mobilization of tumour cells during biopsy in an infant with Ewing sarcoma (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 373-376 
    Details
    ISSN: 1432-1076
    Keywords: Ewing tumours ; EWS-FLI-1 fusion transcripts ; Circulating tumour cells ; Tumour biopsy ; Minimal metastatic disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ewing sarcoma and the closely relate peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene rearrangements on chromosome 22. The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto-oncogens, FLI-1 or ERG, which reside on chromosomes 11 and 21, respectively. The rearrangement results in the expression of specific hybrid transcripts which can be detected with high sensitivity by the reverse transcriptase polymerase chain reaction technique (RT-PCR) in primary tumours, blood and bone marrow. We report on a 7-month-old boy with a pelvic Ewing sarcoma in whom circulating tumour cells were identified in the peripheral blood during open tumour biopsy by RT-PCR. However, before and 6 days after surgery no tumour cells could be detected in the peripheral blood. Conclusion The application of RTPCR to monito shedding of tumour cells during surgical intervention will nelp to evaluate if open biopsy potentially contributes to metastatic tumour cell spread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955264
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mobilization of tumour cells during biopsy in an infant with Ewing sarcoma (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 373-376 
    Details
    ISSN: 1432-1076
    Keywords: Key words Ewing tumours ; EWS-FLI-1 fusion transcripts ; Circulating tumour cells ; Tumour ; biopsy ; Minimal metastatic disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ewing sarcoma and the closely related peripheral primitive neuroectodermal tumour, recently referred to as Ewing tumour (ET), are characterised by unique gene rearrangements on chromosome 22. The breakpoints have been cloned and shown to fuse the Ewing sarcoma gene to one of two closely related ETS proto-oncogens, FLI-1 or ERG, which reside on chromosomes 11 and 21, respectively. The rearrangement results in the expression of specific hybrid transcripts which can be detected with high sensitivity by the reverse transcriptase polymerase chain reaction technique (RT-PCR) in primary tumours, blood and bone marrow. We report on a 7-month-old boy with a pelvic Ewing sarcoma in whom circulating tumour cells were identified in the peripheral blood during open tumour biopsy by RT-PCR. However, before and 6 days after surgery no tumour cells could be detected in the peripheral blood. Conclusion The application of RT-PCR to monitor shedding of tumour cells during surgical intervention will help to evaluate if open biopsy potentially contributes to metastatic tumour cell spread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955264
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Polygonal triple osteotomy of the pelvis (1992)
    Springer
    International orthopaedics 16 (1992), S. 311-316 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs présentent une nouvelle triple ostéotomie (ostéotomie pelvienne polygonale — OPP) pour luxation congénitale de la hanche. L'articulation coxofémorale doit être congruente avec un angle CE compris entre +20° et −10°. L'emploi de modèles, tant avant qu'au cours de l'opération, permet une correction précise de la position du cotyle. La géométrie de l'ostéotomie, combinée à la plaque à compression spéciale de DaVid-Uyka, autorise une mobilisation précoce. L'intervention est indiquée chez les adolescents et les adultes jeunes lorsque les douleurs durent depuis deux mois au moins. L'abord chirurgical, la technique et le traitement postopératoire sont décrits, ainsi que les résultats obtenus dans neuf cas, avec un recul de deux ans.
    Notes: Summary A new triple osteotomy, polygonal pelvic osteotomy (PPO), is described for use in dysplastic hips. The hip joint must be congruous with a centreedge (CE) angle between +20° and −10°. Templates are used before and during operation which allow precise correction of the position of the acetabulum. The geometry of the osteotomy and a special compression plate achieve sufficient stability to permit early mobilisation. Surgery is indicated in adolescents and young adults if pain persists for at least two months. The surgical exposure, operative technique and postoperative management are presented, with the two-year results in nine cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189612
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  • 5
    Electronic Resource
    Electronic Resource
    The benefits of surgery in the treatment of pelvic metastases (1997)
    Springer
    International orthopaedics 21 (1997), S. 343-348 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé.Étude rétrospective des résultats de divers types d’interventions chirurgicales réalisées sur des patients présentant des métastases pelviennes. Nous avons opéré 43 sujets entre 1980 et 1992, 37 ayant subi une curetage des tumeurs, six une résection dans le tissu sain. L’espérance de vie a été calculée selon le procédé Kaplan-Meier, l’état clinique étant évalué au moyen de la méthode de Karnofsky. L’indice Karnofsky est passé de 55% avant l’intervention à 74% trois mois après l’opération (p = 0,0001), et à 77% à six mois (p = 0,0001). L’espérance de vie des sujets ayant subi une curetage de la tumeur s’est avérée être de treize mois en moyenne, avec un taux de complications de 24% et un taux de récidives locales de 19%. Les sujets traités par resection dans le tissu sain ont survécu en moyenne de seize mois. Nous avons vu des complications dans trois cas sur six, sans qu’il y ait eut récidive. Le traitement chirurgical a nettement amélioré la qualité de la vie de nos patients. Compte tenu du taux de complications et de l’espérance de vie de nos malades après intervention, la curetage de la tumeur semblerait être la méthode de choix dans le traitment de ces sujets.
    Notes: Summary. This retrospective study analyses the benefit of surgery to patients with pelvic metastases. Forty-three patients were operated on between 1980 and 1992, 37 having intralesional and 6 extralesional resections. Thirty-nine had perioperative adjuvant therapy. Survival time was calculated by the Kaplan-Meier method. Clinical evaluation used the Karnofsky performance status which showed improvement from 55% before operation to 74% at 3 months (p = 0.0001) and 77% after 6 months (p = 0.0001). Those having an intralesional resection had a median survival time of 13 months, a complication rate of 24% and a local recurrence rate of 19%. The comparable figures for those with extralesional resection were 16 months survival, complications in 3 out of 6, and no local recurrences. The quality of life was improved by operation and intralesional resection is preferable in most of these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050181
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