ISSN:
1432-2013
Keywords:
TSG-6
;
neutrophil infiltration
;
hyaluronan
;
inter-α-inhibitor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract TSG-6 is an arthritis-associated hyaluronan binding protein whose production in synovial cells, chondrocytes, fibroblasts and mononuclear cells is stimulated by TNF-α and IL-1. The purpose of this study was to gain insights into the role of TSG-6 and its functional interactions with hyaluronan in inflammation. In the murine air pouch model of carrageenan/IL-1-induced inflammation TSG-6 showed a dramatic inhibitory effect on the cellular infiltration of the inflammatory site by neutrophilic PNIN, while hyaluronan enhanced cellular infiltration. There was no indication of a neutralizing or cooperative effect when TSG-6 and hyaluronan were injected together. The potent antiinflammatory effect of TSG-6 along with its induction by proinflammatory cytokines suggests that TSG-6 is part of a negative feedback loop in the control of the inflammatory response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02346350
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