ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
—The effects of various cations on the calcium-binding properties of a brain phosphoprotein have been investigated employing an ultrafiltration binding assay. Sodium, magnesium, barium, strontium and manganese ions were competitive inhibitors of the calcium binding, and their affinity for the calcium-binding site increased in the order given. Potassium was a non-competitive inhibitor. Lanthanum, lead, mercuric and cadmium ions precipitated the phosphoprotein from solution. These findings are discussed in relation to a postulated role for the protein as a calcium-receptor molecule involved in release of neurotransmitters.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1972.tb03823.x
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